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Molecular models of protein kinase 6 from Plasmodium falciparum

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Abstract

Cyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the inhibition, and may help designing inhibitors for PfPK6 generating new potential drugs against malaria.

Ribbon diagram of PfPK6 complexed with a roscovitine and b olomoucine

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Acknowledgments

This work was supported by grants from FAPESP (SMOLBNet 01/07532-0, 02/04383-7, 04/00217-0), CNPq, CAPES and Instituto do Milênio (CNPq-MCT). WFA (CNPq, 300851/98-7) is researcher for Brazilian Research Council (CNPq).

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Authors and Affiliations

  1. Departamento de Física, Universidade Estadual Paulista, UNESP, Rua Cristovão Colombo, 2265, 15054-000, São José do Rio Preto, São Paulo, Brasil

    Karisa Karla Manhani, Helen Andrade Arcuri, Nelson José Freitas da Silveira, Hugo Brandão Uchôa, Walter Filgueira de Azevedo Jr & Fernanda Canduri

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  1. Karisa Karla Manhani
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  2. Helen Andrade Arcuri
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  3. Nelson José Freitas da Silveira
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  4. Hugo Brandão Uchôa
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  5. Walter Filgueira de Azevedo Jr
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  6. Fernanda Canduri
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Correspondence to Fernanda Canduri.

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Manhani, K.K., Arcuri, H.A., Silveira, N.J.F.d. et al. Molecular models of protein kinase 6 from Plasmodium falciparum . J Mol Model 12, 42–48 (2005). https://doi.org/10.1007/s00894-005-0002-1

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  • DOI: https://doi.org/10.1007/s00894-005-0002-1

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