Abstract
We performed an epidemiological, clinical and histopathological analysis of oral lymphoid lesions (OLLs) during a 47-year period. Data regarding patient age, sex, duration, location, symptomatology, type of growth, implantation, staining, presence of ulceration and bleeding of all cases were compiled from the clinical data. For the histopathological analyses, all slides stained by H/E were reassessed. During the analyzed period, 14,565 patients with oral and maxillofacial lesions were diagnosed, with 45 cases diagnosed as OLLs. The most prevalent location was the tongue. Females were more affected, and the mean age was 40.8 years. OLLs presented a heterogeneous frequency, with the prevalence of reactive lesions (42.3%) followed by developmental lesions (35.6%). Among the reactive lesions, foreign body granulomas were the most common. Regarding diagnosed neoplasms, malignant represented 13.2% of the cases. The average time of evolution of OLLs in general was of 22.2 months. Regarding the histopathological characteristics, the presence of primary lymphoid follicles was observed in 37.8% of the cases, while inflammatory infiltrates were diffuse in 66.7% and epimyoepithelial islands were observed in 13.3%. Our study concludes that OLLs involves a broad spectrum of lesions that share the presence of the lymphoid component, which can range from indolent to more aggressive behavior.
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References
Greaves W, Wang SA (2011) Selected topics on lymphoid lesions in the head and neck regions. Head Neck Pathol 5:41–50
Ellis G (2007) Lymphoid lesions of salivary glands: malignant and benign. Med Oral Patol Oral Cir Bucal 7:479–485
Ho P, Kyu J, Young K, Baik C, Woo M (2008) Histiocyte-rich reactive lymphoid hyperplasia of the liver: unusual morphologic features. J Korean Med Sci 23:156–160
Pereira A, Nonaka C, Santos P, Medeiros A, Galvão H (2009) Unusual coexistence of oral lymphoepithelial cyst and benign migratory glossitis. Braz J Otorhinolaryngol 75(2):318
Jham B, Binmad N, Scheper M, Zhao X, Koterwas G, Kashyap A et al (2009) Follicular lymphoid hyperplasia of the palate: case report and literature review. J Craniomaxillofac Sug 37:79–82
Jaffe ES (2012) Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis. Mod Pathol 15(3):255–263
Doyle JL, Weisinger E, Manhold JH Jr (1970) Benign lymphoid lesions of the oral mucosa. Oral Surg Oral Med Oral Pathol 29(1):31–37
Seifert G (1980) Lymphoid lesions of the oral cavity. Path Res Pract 167:179–203
Ye Q, Harmsen MC, van Luyn MJA, Bank RA (2010) The relationship between collagen scaffold cross-linking agents and neutrophils in the foreign body reaction. Biomaterials 31:9192–9201
Shahrabi-Farahani S, Lerman MA, Noonan V, Kabani S, Woo SB (2014) Granulomatous foreign body reaction to dermal cosmetic fillers with intraoral migration. Oral Surg Oral Med Oral Pathol Oral Radiol 117:105–110
Owosho AA, Bilodeau EA, Vu J, Summersgill KF (2014) Orofacial dermal fillers: foreign body reactions, histopathologic features, and spectrometric studies. Oral Surg Oral Med Oral Pathol Oral Radiol 117:617–625
Florin W, Mandel L (2012) Foreign body reaction to facial dermal fillers: case report. J Oral Maxillofac Surg 70:2352–2355
Anjomshoaa I, Bulford LA, Dym H, Woo SB (2013) Florid follicular lymphoid hyperplasia of the hard palatal mucosa managed with intralesional steroids: a case report and review of the literature. J Oral Maxillofac Surg 71:1202–1208
Taguchi K, Kuroda S, Kobayashi T, Tashiro H, Ishiyama K, Ide K et al (2015) Pseudolymphoma of the liver: a case report and literature review. Surg Case Rep 1:107
Kolokotronis A, Dimitrakopoulos I, Asimaki A (2003) Follicular lymphoid hyperplasia of the palate: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:172–175
Kojima M, Nakamura S, Shimizu K, Iijima M, Murayama K, Ohno Y et al (2005) Reactive lymphoid hyperplasia of the lymph nodes with giant follicles: a clinicopathologic study of 14 Japanese cases, with special reference to Epstein–Barr virus infection. Int J Surg Pathol 13(3):267–272
Villa N, Redaelli S, Lissoni S, Saccheri S, Sala E, Crosti F et al (2014) Lymph node hyperplasia: clonal chromosomal and genomic rearrangements. Report of two new cases and literature review. Cancer Genetics 207:12–18
Chang DH, Wu PS, Wang YC, Lin CH, Li WY, Ma H et al (2016) Clinicopathology of Immunoglobulin G4-related chronic sclerosing sialadenitis: a single-center study. Otolaryngol Head Neck Surg 155(6):974–981
Adouly T, Adnane C, Housni Y, Rouadi S, Abada R, Roubal M et al (2016) Uncommon situation and presentation of chronic sclerosing sialadenitis. Int J Pediatr Otorhinolaryngol 83:22–24
Gontarz M, Wyszyńska-Pawelec G, Zapała J, Gałązka K, Tomaszewska R, Lazar A (2016) IgG4-related disease in the head and neck region: report of two cases and review of the literature. Pol J Pathol 67(4):370–375
Melo JC, Kitsko D, Reyes-Múgica M (2012) Pediatric chronic sclerosing sialadenitis: Küttner tumor. Pediatr Dev Pathol 15:165–169
Guinovart RM, Bassas-Vila J, Morell L, Ferrándiz C (2014) Angiolymphoid hyperplasia with eosinophilia: A clinicopathologic study of nine cases. Actas Dermosifiliogr 105(2):e1–e6
Tchernev G, Taneva T, Ananiev J, Cardoso JC, Gulubova M, Velev V et al (2012) Angiolymphoid hyperplasia with eosinophilia—an incidental finding after surgical excision. Wien Med Wochenschr 162:448–451
Tenório JR, Gonzaga AKG, Gonçalves PGP, Oliveira DHIP, Queiroz LMG (2016) Angiolymphoid hyperplasia with eosinophilia: a rare case in the oral cavity. J Vasc Bras 15(4):317–321
Lichtenstein L (1953) Integration of eosinophilic granuloma of bone, Letterer–Siwe disease and Schuller-Christian disease as related manifestations of a single nosologic entity. Arch Pathol 56:84–102
Mani V, Vinod VS, George A, Sivaprasad KK (2015) Eosinophilic granuloma of mandibular condyle: resection and complete regeneration. J Maxillofac Oral Surg 14(1):107–110
Lichtenstein L, Jaffe HL (1940) Eosinophilic granuloma of bone with a report of a case. Am J Pathol 16:595–604
Angelini A, Mavrogenis AF, Rimondi E, Rossi G, Ruggieri P (2017) Current concepts for the diagnosis and management of eosinophilic granuloma of bone. J Orthop Traumatol 18:83–90
Khelemsky R, Mandel L (2010) Lymphoepithelial cyst of mouth floor. J Oral Maxillofac Surg 2010; 68:3055–3057
Sykara M, Ntovas P, Kalogirou EM, Tosios KI, Sklavounou A (2017) Oral lymphoepithelial cyst: A clinicopathological study of 26 cases and review of the literature. J Clin Exp Dent 9(8):e1035–e1043
Knapp MJ (1970) Pathology of oral tonsils. Oral Surg Oral Med Oral Pathol 29:295–304
Castro JGL, Ferreira GM, Mendonça EF, Castro LA (2015) A rare occurrence of lymphoepithelial cyst in the palatine tonsil: a case report and discussion of the etiopathogenesis. Int J Clin Exp Pathol 8(4):4264–4268
Jeong HS, Lee HK, Ha YJ, Kim DH, Suh IS (2015) Benign lymphoepithelial lesion of parotid gland and secondary amyloidosis as concurrent manifestations in Sjögren’s syndrome. Arch Plast Surg 42:380–383
Li QJ, Zhao PX, Zhang XJ, Yi Y, Chen DY, Ma JM et al (2017) Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland. Int J Ophthalmol 10(8):1229–1232
Uehara T, Ikeda SI, Hamano H, Kawa S, Moteki H, Matsuda K et al (2012) A case of Mikulicz’s Disease complicated by malignant lymphoma: a postmortem histopathological finding. Intern Med 51:419–423
Metwaly H, Cheng J, Suzuki M, Takata Y, Saitoh C, Hayashi T et al (2004) Benign lymphoepithelial lesion of minor salivary gland: report of a case involving the palatal mucosa. Oral Oncol EXTRA 40:113–116
Raghu AR, Rehani S, Bishen KA, Sagari S (2014) Warthin’s tumour: a case report and review on pathogenesis and its histological subtypes. J Clin Diagn Res 8(9):ZD37–ZD40
Iwai T, Baba J, Murata S, Mitsudo K, Maegawa J, Nagahama K et al (2012) Warthin tumor arising from the minor salivary gland. J Craniofac Surg 23(5):e374–e376
Arcega RS, Feinstein AJ, Bhuta S, Blackwell KE, Rao NP, Pullarkat ST (2015) An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. Diagn Pathol 3(10):209
Sagiv D, Witt RL, Glikson E, Mansour J, Shalmon B, Yakirevitch A et al (2017) Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. Eur Arch Otorhinolaryngol 274:1993–1996
Armitage JO, Gascoyne RD, Lunning MA, Cavalli F (2017) Non-hodgkin lymphoma. Lancet 390:298–310
Inchingolo F, Tatullo M, Abenavoli FM, Marrelli M, Inchingolo AD, Inchingolo AM et al (2011) Non-hodgkin lymphoma affecting the tongue: unusual intra-oral location. Head Neck Oncol 3:1
Varun BR, Varghese NO, Sivakumar TT, Joseph AP (2017) Extranodal non-hodgkin’s lymphoma of the oral cavity: A Case Rep. Iran J Med Sci 42(4):407–411
Pereira DL, Fernandes DT, Santos-Silva AR, Vargas PA, Almeida OP, Lopes MA (2015) Intraosseous non-hodgkin lymphoma mimicking a periapical lesion. J Endod 41:1738–1742
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H et al (2013) Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 49:1374–1403
Fetica B, Achimas-Cadariu P, Pop B, Dima D, Petrov L, Perry AM et al (2017) Non-hodgkin lymphoma in Romania: a single-centre experience. Hematol Oncol 35:198–205
Ninkovic S, Lambert J (2017) Non-hodgkin lymphoma. Medicine 45(5):297–304
Amoils M, Truong MT (2016) Burkitt lymphoma presenting as facial nerve paresis. Int J Pediatr Otorhinolaryngol Extra 13:9–12
Rebelo-Pontes HA, Abreu MC, Guimarães DM, Fonseca FP, Andrade BAB, Almeida OP et al (2014) Burkitt’s lymphoma of the jaws in the Amazon region of Brazil. Med Oral Patol Oral Cir Bucal 19(1):e32–e38
Zongo N, Sanou/Lamien A, Konsegré V, Ouédraogo A, Randé N, Goumbri/Lompo O et al (2011) Burkitt lymphomas: epidemiological and pathological aspects in Ouagadougou (Burkina Faso) Afr J Cancer 3(1):16–19
Mohtasham N, Babakoohi S, Sarraf-Yadzy M, Sadr B, Ghaffarzadegan K, Shiva A et al (2011) Oral and jaw lymphoma in an Iranian population. J Craniofac Surg 22:868–870
Bilodeau E, Galambos C, Yeung A, Potluri A, Collins B (2012) Sporadic Burkitt lymphoma of the jaw: case report and review of the literature. Quintessence Int 43:333–336
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The work was supported by Oral Pathology Post-Graduation Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
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The author Juliana Campos Pinheiro declares that he has no conflict of interest; author Caio César da Silva Barros declares that he has no conflict of interest; author Larissa Santos Amaral Rolim declares that he has no conflict of interest; author Leão Pereira Pinto declares that he has no conflict of interest; author Lélia Batista de Souza declares that he has no conflict of interest; author Pedro Paulo de Andrade Santos declares that he has no conflict of interest.
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Pinheiro, J.C., da Silva Barros, C.C., Rolim, L.S.A. et al. Oral lymphoid lesions: a 47-year clinicopathological study in a Brazilian population. Med Mol Morphol 52, 123–134 (2019). https://doi.org/10.1007/s00795-018-0210-2
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DOI: https://doi.org/10.1007/s00795-018-0210-2