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Adenomatous ductal proliferation/hyperplasia in the parotid gland associated without any other pathological lesions; a report and survey of the literatures

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Abstract

Adenomatous ductal proliferation/hyperplasia (ADP/H) is a rare hyperplastic condition of the salivary gland. It is mostly associated with other salivary gland pathologies such as tumors and inflammations, and is incidentally found in tissue sections during histopathological examinations of those diseases. Herein, we report a case of ADP/H in the parotid gland not associated with any other pathological lesions, and present a review of the literature on this condition. A 60-year-old Japanese female complained of swelling on the left side of parotid region. Clinical examination revealed a swelling on the lower lobe of the left parotid gland. The lesion was firm but non-tender and was not attached to adjacent structures. A clinical diagnosis of benign salivary gland tumor was reached, and surgical excision was performed under general anesthesia. Histopathological examination revealed an intact parotid gland capsule with isomorphic and basaloid cells within scanty cytoplasm. In addition, an admixture of hyperplasia and proliferation of the intercalated ducts, the presence of zymogen granules, the absence of solid nests, and a peripheral palisaded arrangement of the cells were observed. Based on these findings, a diagnosis of ADP/H was confirmed. ADP/H is a non-tumorous lesion; therefore, tumor involvement should be ruled out before the diagnosis is reached.

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Authors and Affiliations

  1. Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan

    Bhoj Raj Adhikari, Michiko Nishimura, Fumiya Harada, Aya Onishi, Daichi Hiraki, Durga Paudel, Puja Neopane, Masafumi Utsunomiya, Tetsuro Morikawa, Koki Yoshida, Jun Sato & Yoshihiro Abiko

  2. Division of Oral and Maxillofacial Surgery, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan

    Kosuke Takimoto, Mamata Shakya & Hiroki Nagayasu

  3. Division of Oral and Maxillofacial Radiology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan

    Eiji Nakayama

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  1. Bhoj Raj Adhikari
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  2. Michiko Nishimura
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  3. Kosuke Takimoto
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  4. Fumiya Harada
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  5. Aya Onishi
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  7. Durga Paudel
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  8. Puja Neopane
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  9. Masafumi Utsunomiya
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  11. Koki Yoshida
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  12. Jun Sato
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  13. Mamata Shakya
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  14. Eiji Nakayama
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  15. Hiroki Nagayasu
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  16. Yoshihiro Abiko
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Correspondence to Yoshihiro Abiko.

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Adhikari, B.R., Nishimura, M., Takimoto, K. et al. Adenomatous ductal proliferation/hyperplasia in the parotid gland associated without any other pathological lesions; a report and survey of the literatures. Med Mol Morphol 51, 244–248 (2018). https://doi.org/10.1007/s00795-018-0192-0

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  • DOI: https://doi.org/10.1007/s00795-018-0192-0

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