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Insulinoma-associated protein 1 (INSM1) is a useful marker for pancreatic neuroendocrine tumor

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Abstract

Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysin (SYP), and neural cell adhesion molecule (NCAM) were also considered as potential biomarkers. However, it is often difficult to diagnose it immunohistochemically. Hence, we examined the expression pattern of INSM1 in pancreatic solid tumors. We detected INSM1, CGA, SYP, and NCAM immunohistochemically, in 27 cases of NET [pure type: 25 cases, mixed adenoneuroendocrine carcinoma (MANEC): 2 cases]. We included 5 cases of solid-pseudopapillary neoplasm (SPN), 7 cases of acinar cell carcinoma (ACC), and 15 cases of pancreatic ductal adenocarcinoma (PDAC) as the control group. Nuclear expression of INSM1 was found in all PanNET pure type cases. However, expression of INSM1 was negative in PDAC, ACC, and SPN in all cases, whereas faint expression was seen in the cytoplasm from SPN. MANEC comprises of two components: neuroendocrine carcinoma and adenocarcinoma components. The NET component was positive for INSM1 expression, whereas the PDAC component does not express INSM1, which aids in distinguishing these components. Our results suggest that INSM1 is a useful immunohistochemical marker for diagnosing pancreatic neuroendocrine tumor.

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Author notes

  1. Masahiko Tanigawa and Masamichi Nakayama have contributed equally to all experimental aspects of this work.

Authors and Affiliations

  1. Department of Pathology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan

    Masahiko Tanigawa, Masamichi Nakayama, Yutaro Mihara, Reiichiro Kondo, Hironori Kusano, Ken Nakamura, Yushi Abe, Yoshiki Naito & Hirohisa Yano

  2. Department of Surgery, Kurume University School of Medicine, Kurume, Japan

    Masahiko Tanigawa, Yutaro Mihara, Toru Hisaka, Koji Okuda & Yoshito Akagi

  3. Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan

    Tomoki Taira, Akihiko Kawahara, Yoshiki Naito & Jun Akiba

  4. Biostatistics Center, Kurume University School of Medicine, Kurume, Japan

    Satoshi Hattori

  5. Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan

    Yusuke Ishida & Yoshinobu Okabe

  6. Department of Pathology and Experimental Medicine, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan

    Kosuke Fujino & Takaaki Ito

  7. Department of Pathology and Laboratory Medicine, Kurume University Medical Center, Kurume, Japan

    Rin Yamaguchi

Authors
  1. Masahiko Tanigawa
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  2. Masamichi Nakayama
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  3. Tomoki Taira
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  8. Ken Nakamura
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  9. Yushi Abe
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  10. Yusuke Ishida
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  13. Koji Okuda
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  14. Kosuke Fujino
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  15. Takaaki Ito
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  16. Akihiko Kawahara
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  17. Yoshiki Naito
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  18. Rin Yamaguchi
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  19. Jun Akiba
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  20. Yoshito Akagi
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  21. Hirohisa Yano
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Corresponding author

Correspondence to Yoshiki Naito.

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Tanigawa, M., Nakayama, M., Taira, T. et al. Insulinoma-associated protein 1 (INSM1) is a useful marker for pancreatic neuroendocrine tumor. Med Mol Morphol 51, 32–40 (2018). https://doi.org/10.1007/s00795-017-0167-6

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  • DOI: https://doi.org/10.1007/s00795-017-0167-6

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