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Involvement of liver-intestine cadherin in cancer progression

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Abstract

Cadherins constitute a superfamily of Ca2+-dependent cell adhesion molecules that play critical roles in the maintenance of tissue structure and morphogenesis. Their dysregulation is commonly observed in a variety of cancers. Liver-intestine cadherin (LI-cadherin), which was so named in view of its sole expression in the liver and intestine of the rat, is a structurally unique member of the cadherin superfamily, possessing seven cadherin repeats within the extracellular cadherin domain and only 25 amino acids in the cytoplasmic domain. Its adhesive property does not require any interaction with cytoplasmic components such as catenins, and it responds to small changes in extracellular Ca2+ below the physiological plasma concentration. In humans, the distribution of LI-cadherin is limited to the duodenum, jejunum, ileum, colon, and part of the pancreatic duct. Data accumulated from studies of the biological characteristics of LI-cadherin have shown that it plays an important role in the pathophysiology of human cancers. Here, we review recent information about LI-cadherin and its implications for cancer progression.

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Acknowledgments

This work was supported by Grant-in-Aid for Young Scientists (B) (No. 23790779) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan

    Masaaki Takamura, Satoshi Yamagiwa & Yutaka Aoyagi

  2. Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata, Japan

    Yasunobu Matsuda

  3. Division of Gastroenterology and Hepatology, Shizuoka Hospital, Juntendo University School of Medicine, Izunokuni, Japan

    Takafumi Ichida

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  1. Masaaki Takamura
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  2. Satoshi Yamagiwa
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  3. Yasunobu Matsuda
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  4. Takafumi Ichida
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  5. Yutaka Aoyagi
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Correspondence to Masaaki Takamura.

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Takamura, M., Yamagiwa, S., Matsuda, Y. et al. Involvement of liver-intestine cadherin in cancer progression. Med Mol Morphol 46, 1–7 (2013). https://doi.org/10.1007/s00795-012-0003-y

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