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Chromophobe renal cell carcinoma: useful diagnostic application of imprint cytology and fluorescence in situ hybridization of chromosomes 10 and 21 in two cases of typical and eosinophilic variants

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Abstract

Chromophobe renal cell carcinoma (RCC) is subdivided into typical and eosinophilic variants. We report such two cases with focus on imprint cytology and fluorescence in situ hybridization (FISH). The first case is a 53-year-old Japanese man and the second is a 76-year-old Japanese man. Histologically, the diagnosis of typical and eosinophilic variants of chromophobe RCC was suspected. In imprint cytology, irregularity of nuclear membrane, binucleation, perinuclear halo, and thick cell border were observed. Immunohistochemically, neoplastic cells of both tumors were positive for cytokeratin 7, E-cadherin, c-kit, and CD10. In FISH study, both tumors revealed the monosomy of chromosomes 10 and 21. Additionally, FISH study in eosinophilic variant of chromophobe RCC showed the disomy of chromosomes 7 and 17. In conclusion, we suggest that the combination study of imprint cytology and FISH of chromosomes 10 and 21 as well as routine histology may contribute to the accurate diagnosis of chromophobe RCC.

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Authors and Affiliations

  1. Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi, 780-8562, Japan

    Naoto Kuroda

  2. Department of Urology, Kochi Red Cross Hospital, Kochi, Japan

    Kazunobu Katto

  3. Department of Pathology, Ayabe City Hospital, Kyoto, Japan

    Tadanori Yamaguchi

  4. Department of Pathology, Maizuru Kyosai Hospital, Kyoto, Japan

    Takako Kawada

  5. Division of Surgical Pathology, University of Fukui Hospital, Fukui, Japan

    Yoshiaki Imamura

  6. Department of Pathology, Charles University Hospital, Plzen, Czech Republic

    Ondrej Hes & Michal Michal

  7. Department of Urology, Kochi Medical School, Kochi University, Kochi, Japan

    Taro Shuin

  8. Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan

    Gang-Hong Lee

Authors
  1. Naoto Kuroda
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  2. Kazunobu Katto
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  3. Tadanori Yamaguchi
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  4. Takako Kawada
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  5. Yoshiaki Imamura
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  6. Ondrej Hes
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  7. Michal Michal
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  8. Taro Shuin
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  9. Gang-Hong Lee
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Correspondence to Naoto Kuroda.

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Kuroda, N., Katto, K., Yamaguchi, T. et al. Chromophobe renal cell carcinoma: useful diagnostic application of imprint cytology and fluorescence in situ hybridization of chromosomes 10 and 21 in two cases of typical and eosinophilic variants. Med Mol Morphol 41, 227–232 (2008). https://doi.org/10.1007/s00795-008-0406-y

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  • DOI: https://doi.org/10.1007/s00795-008-0406-y

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