Abstract
Mental disorders account for a large and increasing health burden worldwide, as shown in the Global Burden of Diseases (GBD) Study 2010. Unpacking how this burden in children and adolescents varies with sex, geographical regions, and ethnicities and how it has changed in the last 3 decades are important to improve the existing public health policies and prevention strategies. The study was conducted using GBD 2019 database. The burden of children and adolescents’ (< 20 years old) mental disorders was displayed as prevalence, incidence, disability-adjusted life-years (DALYs), years of life lost, and years lived with disability globally between 1990 and 2019. The number of DALYs in children and adolescents diagnosed with mental disorders was 21.5 million (95% CI: 15.2–29.6 million) in 2019. From 1990 to 2019, the age-standardized rates of DALYs of mental disorders increased from 803.8 per 100,000 (95% CI: 567.7–1104.3 per 100,000) to 833.2 per 100,000 (95% CI: 589.0–1146.1 per 100,000) population. Over the past 30 years, there had been a huge increase in the number of individuals suffering from anxiety disorders, major depressive disorders, and conduct disorders including an alarming increase in the rate of eating disorders such as 24.3% in bulimia nervosa and 17.0% in anorexia nervosa. Globally, 8.8% of children and adolescents have been diagnosed with varieties of mental illnesses, accounting for a heavy disease burden on public health. Besides, the worldwide increasing rates of anxiety disorders, major depressive disorders, and eating disorders have brought considerable challenges to public health undertakings, for which further prevention and treatment countermeasures are urgently needed.
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Abbreviations
- The GBD study:
-
The Global Burden of Diseases study
- WMH Survey:
-
World Mental Health Survey
- DSM:
-
The American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders
- ICD:
-
International Classification of Diseases
- YLLs:
-
Years of life lost
- YLDs:
-
Years lived with disability
- DALYs:
-
Disability-adjusted life-years
- SDI:
-
Socio-demographic index
- UI:
-
Uncertainty interval
References
Lawrence D, Kisely S, Pais J (2010) The epidemiology of excess mortality in people with mental illness. Can J Psychiatr 55:752–760
Scott KM, Lim C, Al-Hamzawi A, Alonso J, Bruffaerts R, Caldas-de-Almeida JM, Florescu S, de Girolamo G, Hu C, de Jonge P, Kawakami N, Medina-Mora ME, Moskalewicz J, Navarro-Mateu F, O’Neill S, Piazza M, Posada-Villa J, Torres Y, Kessler RC (2016) Association of mental disorders with subsequent chronic physical conditions: world mental health surveys from 17 countries. JAMA Psychiat 73:150–158
Wahlbeck K, Westman J, Nordentoft M, Gissler M, Laursen TM (2011) Outcomes of Nordic mental health systems: life expectancy of patients with mental disorders. Br J Psychiatr 199:453–458
Scott KM, de Jonge P, Alonso J, Viana MC, Liu Z, O’Neill S, Aguilar-Gaxiola S, Bruffaerts R, Caldas-de-Almeida JM, Stein DJ, de Girolamo G, Florescu SE, Hu C, Taib NI, Lepine JP, Levinson D, Matschinger H, Medina-Mora ME, Piazza M, Posada-Villa JA, Uda H, Wojtyniak BJ, Lim CC, Kessler RC (2013) Associations between DSM-IV mental disorders and subsequent heart disease onset: beyond depression. Int J Cardiol 168:5293–5299
Cunningham R, Sarfati D, Peterson D, Stanley J, Collings S (2014) Premature mortality in adults using New Zealand psychiatric services. N Z Med J 127:31–41
Collaborators GBDMD (2022) Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatr 9:137–150
Kessler RC, Aguilar-Gaxiola S, Alonso J, Chatterji S, Lee S, Ustun TB (2009) The WHO World Mental Health (WMH) Surveys. Psychiatrie (Stuttg) 6:5–9
Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, Charlson FJ, Norman RE, Flaxman AD, Johns N, Burstein R, Murray CJ, Vos T (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382:1575–1586
Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, Silove D (2014) The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013. Int J Epidemiol 43:476–493
Kessler RC, Aguilar-Gaxiola S, Alonso J, Chatterji S, Lee S, Ormel J, Ustun TB, Wang PS (2009) The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys. Epidemiol Psichiatr Soc 18:23–33
Wang PS, Aguilar-Gaxiola S, Alonso J, Angermeyer MC, Borges G, Bromet EJ, Bruffaerts R, de Girolamo G, de Graaf R, Gureje O, Haro JM, Karam EG, Kessler RC, Kovess V, Lane MC, Lee S, Levinson D, Ono Y, Petukhova M, Posada-Villa J, Seedat S, Wells JE (2007) Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys. Lancet 370:841–850
Houtrow AJ, Larson K, Olson LM, Newacheck PW, Halfon N (2014) Changing trends of childhood disability, 2001–2011. Pediatrics 134:530–538
Baranne ML, Falissard B (2018) Global burden of mental disorders among children aged 5–14 years. Child Adolesc Psychiatr Ment Health 12:19
Polanczyk GV, Salum GA, Sugaya LS, Caye A, Rohde LA (2015) Annual research review: A meta-analysis of the worldwide prevalence of mental disorders in children and adolescents. J Child Psychol Psychiatr 56:345–365
Association WDCAP (2013) American psychiatric association Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Am Psychiatric Assoc. https://doi.org/10.1176/appi.books.9780890425596
Diseases GBD, Injuries C (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396:1204–1222
Collaborators GBDV (2020) Five insights from the Global Burden of Disease Study 2019. Lancet 396:1135–1159
Xu T, Wang B, Liu H, Wang H, Yin P, Dong W, Li J, Wang YX, Yusufu M, Briant P, Reinig N, Ashbaugh C, Adelson J, Vos T, Bourne R, Wang N, Zhou M (2020) Prevalence and causes of vision loss in China from 1990 to 2019: findings from the Global Burden of Disease Study 2019. Lancet Public Health 5:e682–e691
Collaborators GBDEMRAH (2018) Adolescent health in the Eastern Mediterranean Region: findings from the global burden of disease 2015 study. Int J Public Health 63:79–96
Wu J, Liu J, Li S, Ma H, Wang Y (2020) Trends in the prevalence and disability-adjusted life years of eating disorders from 1990 to 2017: results from the Global Burden of Disease Study 2017. Epidemiol Psychiatr Sci 29:e191
Johnson EL, Salafia EHB (2022) Mediating effects of intimacy between body talk and girls’ body dissatisfaction: the forgotten sibling relationship. J Youth Adolesc 51:1230–1240
Purkiewicz A, Kamelska-Sadowska AM, Ciborska J, Mikulska J, Pietrzak-Fiecko R (2021) Risk factors for eating disorders and perception of body in young adults associated with sex. Nutrients 13(8):2819
Bachner-Melman R, Watermann Y, Lev-Ari L, Zohar AH (2022) Associations of self-repression with disordered eating and symptoms of other psychopathologies for men and women. J Eat Disord 10:41
Jackson T, Chen H (2008) Predicting changes in eating disorder symptoms among Chinese adolescents: a 9 month prospective study. J Psychosom Res 64:87–95
Karam SM, Barros AJ, Matijasevich A, Dos Santos IS, Anselmi L, Barros F, Leistner-Segal S, Felix TM, Riegel M, Maluf SW, Giugliani R, Black MM (2016) Intellectual disability in a birth cohort: prevalence, etiology, and determinants at the age of 4 years. Public Health Genomics 19:290–297
Hillemeier MM, Morgan PL, Farkas G, Maczuga SA (2011) Perinatal and socioeconomic risk factors for variable and persistent cognitive delay at 24 and 48 months of age in a national sample. Matern Child Health J 15:1001–1010
Arcelus J, Mitchell AJ, Wales J, Nielsen S (2011) Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies. Arch Gen Psychiatr 68:724–731
Johnson JG, Cohen P, Kasen S, Brook JS (2002) Eating disorders during adolescence and the risk for physical and mental disorders during early adulthood. Arch Gen Psychiatr 59:545–552
Bergen DC (2008) Effects of poverty on cognitive function: a hidden neurologic epidemic. Neurology 71:447–451
Engle PL, Black MM (2008) The effect of poverty on child development and educational outcomes. Ann N Y Acad Sci 1136:243–256
Morgan PL, Staff J, Hillemeier MM, Farkas G, Maczuga S (2013) Racial and ethnic disparities in ADHD diagnosis from kindergarten to eighth grade. Pediatrics 132:85–93
Alonso J, Liu Z, Evans-Lacko S, Sadikova E, Sampson N, Chatterji S, Abdulmalik J, Aguilar-Gaxiola S, Al-Hamzawi A, Andrade LH, Bruffaerts R, Cardoso G, Cia A, Florescu S, de Girolamo G, Gureje O, Haro JM, He Y, de Jonge P, Karam EG, Kawakami N, Kovess-Masfety V, Lee S, Levinson D, Medina-Mora ME, Navarro-Mateu F, Pennell BE, Piazza M, Posada-Villa J, Ten Have M, Zarkov Z, Kessler RC, Thornicroft G, Collaborators WHOWMHS (2018) Treatment gap for anxiety disorders is global: Results of the World Mental Health Surveys in 21 countries. Depress Anxiety 35:195–208
Perez MI, Limon DL, Candelari AE, Cepeda SL, Ramirez AC, Guzick AG, Kook M, La Buissonniere AV, Schneider SC, Goodman WK, Storch EA (2022) Obsessive-compulsive disorder misdiagnosis among MENTAL HEALTHCARE PROVIDERS in Latin America. J Obsessive Compuls Relat Disord 32:100693
Baca E, Lazaro J, Hernandez-Clemente JC (2010) Historical perspectives of the role of Spain and Portugal in today’s status of psychiatry and mental health in Latin America. Int Rev Psychiatr 22:311–316
Schnyder N, Panczak R, Groth N, Schultze-Lutter F (2017) Association between mental health-related stigma and active help-seeking: systematic review and meta-analysis. Br J Psychiatr 210:261–268
McGrath JJ, Lim CCW, Plana-Ripoll O, Holtz Y, Agerbo E, Momen NC, Mortensen PB, Pedersen CB, Abdulmalik J, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Bromet EJ, Bruffaerts R, Bunting B, de Almeida JMC, de Girolamo G, De Vries YA, Florescu S, Gureje O, Haro JM, Harris MG, Hu C, Karam EG, Kawakami N, Kiejna A, Kovess-Masfety V, Lee S, Mneimneh Z, Navarro-Mateu F, Orozco R, Posada-Villa J, Roest AM, Saha S, Scott KM, Stagnaro JC, Stein DJ, Torres Y, Viana MC, Ziv Y, Kessler RC, de Jonge P (2020) Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries. Epidemiol Psychiatr Sci 29:e153
Plana-Ripoll O, Musliner KL, Dalsgaard S, Momen NC, Weye N, Christensen MK, Agerbo E, Iburg KM, Laursen TM, Mortensen PB, Pedersen CB, Petersen LV, Santomauro DF, Vilhjalmsson BJ, Whiteford HA, McGrath JJ (2020) Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population-based cohort study. World Psychiatr 19:339–349
Acknowledgements
We highly appreciate the work by the GBD 2019 collaborators.
Funding
This work was supported by a National Natural Science Foundation of China (NSFC) grant (Grant No: 82000754) to Dr. He Xue, a Youth Backbone Support Program of China Medical University (QGZD2018013) to Dr. He Xue, and a Jilin health talent grant (Grant No: JLSWSRCZX2021-037) to Dr. Piao Jianmin. The funders played no role in study design, data collection and analysis, the decision to publish, or preparation of the manuscript. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication.
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Piao, J., Huang, Y., Han, C. et al. Alarming changes in the global burden of mental disorders in children and adolescents from 1990 to 2019: a systematic analysis for the Global Burden of Disease study. Eur Child Adolesc Psychiatry 31, 1827–1845 (2022). https://doi.org/10.1007/s00787-022-02040-4
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DOI: https://doi.org/10.1007/s00787-022-02040-4