Skip to main content

Advertisement

Log in

Drug and non-drug treatments of children with ADHD and tic disorders

  • ORIGINAL CONTRIBUTION
  • Published:
European Child & Adolescent Psychiatry Aims and scope Submit manuscript

Abstract

Objective

To review the treatment of ADHD in children with chronic tic disorders.

Background

Tic disorders are relatively common in school-age children and range from mild to severe. Children with mild tics may not require medication for the treatment of tics. The co-occurrence of attention deficit hyperactivity disorder (ADHD) and disruptive behavior are common in children with tic disorders and may be associated with significant morbidity.

Methods

We conducted a literature search to identify reports of tics as an adverse effect to stimulant medication, the treatment of children with ADHD and tics as well as novel treatments that have been proposed for the treatment of ADHD in children with tic disorders.

Results

The preponderance of evidence suggests that stimulant medications are safe and effective in the treatment of children with ADHD and tic disorders. A minority of children with tic disorders may show a worsening of tics or not tolerate stimulants for other reasons. The growing list of non-stimulants provides options for clinicians and parents of these children.

Conclusions

Treatment planning for children with ADHD and tic disorders involves careful discussion with parents on choosing the best course of action. Stimulants should be part of this discussion. More study is needed on non-pharmacological approaches to the treatment of tics and ADHD in this population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Abikoff H, Hechtman L, Klein RG, Gallagher R, Fleiss K, Etcovitch J, Cousins L, Greenfield B, Martin D, Pollack S (2004) Social functioning in children with ADHD treated with long-term methylphenidate and multimodal psychosocial treatment. J Am Acad Child Adolesc Psychiatry 43(7):820–829

    PubMed  Google Scholar 

  2. Acosta MT, Leon-Sarmiento FE (2003) Repetitive transcranial magnetic stimulation (rTMS): new tool, new therapy and new hope for ADHD. Curr Med Res Opin 19:125–130

    PubMed  Google Scholar 

  3. Adriani W, Rea M, Baviera M, Invernizzi W, Carli M, Ghirardi O, Caprioli A, Laviola G (2004) Acetyl-l-carnitine reduces impulsive behaviour in adolescent rats. Psychopharmacology 176:296–304

    PubMed  CAS  Google Scholar 

  4. Agarwal V, Sitholey P, Kumar S, Prasad M (2001) Double-blind, placebo-controlled trial of clonidine in hyperactive children with mental retardation. Ment Retard 39:259–267

    PubMed  CAS  Google Scholar 

  5. Ahmann PA, Waltonen SJ, Olson KA, Theye FW, Van Erem AJ, LaPlant RJ (1993) Placebo-controlled evaluation of Ritalin side effects. Pediatrics 91:1101–1106

    PubMed  CAS  Google Scholar 

  6. Akhondzadeh S, Mohammadi MR, Khademi M (2004) Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: a double blind and randomized trial [ISRCTN64132371] BMC Psychiatry Apr. 8:4:9

    Google Scholar 

  7. Allen AJ, Kurlan RM, Gilbert DL, Coffey BJ, Linder SL, Lewis DW, Winner PK, Dunn DW, Dure LS, Sallee FR, Milton DR, Mintz MI, Ricardi RK, Erenberg G, Layton LL, Feldman PD, Kelsey DK, Spencer TJ (2005) Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders. Neurology 65:1941–1949

    PubMed  CAS  Google Scholar 

  8. Aman MG, Binder C, Turgay A (2004) Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. J Child Adolesc Psychopharmacol 14:243–254

    PubMed  Google Scholar 

  9. American Psychiatric Association, American Psychiatric Association. Task Force on DSM-IV (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR. American Psychiatric Association, Washington, DC

    Google Scholar 

  10. Anastopoulos AD, DuPaul GJ, Barkley RA (1991) Stimulant medication and parent training therapies for attention deficit-hyperactivity disorder. J Learning Disabil 24(4):210–218

    CAS  Google Scholar 

  11. Angold A, Erkanli A, Egger HL, Costello EJ (2000) Stimulant treatment for children: a community perspective. J Am Acad Child Adolesc Psychiatry 39:975–984; discussion 984–994

    PubMed  CAS  Google Scholar 

  12. Anonymous (2004) 2005 Physicians’ Desk Reference. Thomson Healthcare

  13. Arnold LE, DiSilvestro RA (2005) Zinc in attention-deficit/hyperactivity disorder. [Review] [68 refs] J Child Adolesc Psychopharmacol 15:619–627

    PubMed  Google Scholar 

  14. Bailey J (2004) An exceptional case of plagiarism. J Psychopharmacol 18:291–292

    PubMed  Google Scholar 

  15. Banaschewski T, Roessner V, Dittmann RW, Santosh PJ, Rothenberger A (2004) Non-stimulant medications in the treatment of ADHD. Eur Child Adolesc Psychiatry 13(1):102–116

    Google Scholar 

  16. Banaschewski T, Coghill D, Santosh P, Zuddas A, Ascherson P, Buitelaar J, Danckaerts M, Döpfner M, Faraone SV, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke EJ, Taylor E (2006) Long-acting medications for the hyperkinetic disorders: a systematic review and European guideline. Eur Child Adolesc Psychiatry 15:476–495

    PubMed  Google Scholar 

  17. Barkley RA, McMurray MB, Edelbrock CS, Robbins K (1990) Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation. Pediatrics 86(2):184–192

    PubMed  CAS  Google Scholar 

  18. Barrickman LL, Perry PJ, Allen AJ, Kuperman S, Arndt SV, Herrmann KJ, Schumacher E (1995) Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 34:649–657

    PubMed  CAS  Google Scholar 

  19. Belson MG, Kelley TR (2002) Bupropion exposures: clinical manifestations and medical outcome. J Emergency Med 23(3):223–230

    Google Scholar 

  20. Biederman J, Baldessarini RJ, Wright V, Knee D, Harmatz JS (1989) A double-blind placebo controlled study of desipramine in the treatment of ADD: I. Efficacy. J Am Acad Child Adolesc Psychiatry 28:777–784

    PubMed  CAS  Google Scholar 

  21. Biederman J, Swanson JM, Wigal SB, Kratochvil CJ, Boellner SW, Earl CQ, Jiang J, Greenhill L (2005) Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, flexible-dose study. Pediatrics 116:e777–e784

    PubMed  Google Scholar 

  22. Bilici M, Yildirim F, Kandil S, Bekaroglu M, Yildirmis S, Deger O, Ulgen M, Yildiran A, Aksu H (2004) Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 28:181–190

    PubMed  CAS  Google Scholar 

  23. Borcherding BG, Keysor CS, Rapoport JL, Elia J, Amass J (1990) Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability? Psychiatry Res 33:83–94

    PubMed  CAS  Google Scholar 

  24. Buitelaar JK, van der Gaag RJ, Swaab-Barneveld H, Kuiper M (1996) Pindolol and methylphenidate in children with attention-deficit hyperactivity disorder. Clinical efficacy and side-effects. J Child Psychol Psychiatry 37:587–595

    PubMed  CAS  Google Scholar 

  25. Casat CD, Pleasants DZ, Schroeder DH, Parler DW (1989) Bupropion in children with attention deficit disorder. Psychopharmacol Bull 25:198–201

    PubMed  CAS  Google Scholar 

  26. Casat CD, Pleasants DZ, Van Wyck Fleet J (1987) A double-blind trial of bupropion in children with attention deficit disorder. Psychopharmacol Bull 23:120–122

    PubMed  CAS  Google Scholar 

  27. Castellanos FX, Giedd JN, Elia J, Marsh WL, Ritchie GF, Hamburger SD, Rapoport JL (1997) Controlled stimulant treatment of ADHD and comorbid Tourette’s syndrome: effects of stimulant and dose. J Am Acad Child Adolesc Psychiatry 36:589–596

    PubMed  CAS  Google Scholar 

  28. Chae JH, Nahas Z, Wassermann E, Li X, Sethuraman G, Gilbert D, Sallee FR, George MS (2004) A pilot safety study of repetitive transcranial magnetic stimulation (rTMS) in Tourette’s syndrome. Cogn Behav Neurol 17:109–117

    PubMed  Google Scholar 

  29. Chappell PB, Riddle MA, Scahill L, Lynch KA, Schultz R, Arnsten A, Leckman JF, Cohen DJ (1995) Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette’s syndrome: preliminary clinical experience. J Am Acad Child Adolesc Psychiatry 34:1140–1146

    PubMed  CAS  Google Scholar 

  30. Chatfield J (2002) AAP guideline on treatment of children with ADHD. American Academy of Pediatrics. Am Fam Physician 65:726–728

    PubMed  Google Scholar 

  31. Comings DE, Comings BG (1987) A controlled study of Tourette syndrome. I. Attention-deficit disorder, learning disorders, and school problems. Am J Hum Genet 41:701–741

    PubMed  CAS  Google Scholar 

  32. Conners CK, Casat CD, Gualtieri CT, Weller E, Reader M, Reiss A, Weller RA, Khayrallah M, Ascher J (1996) Bupropion hydrochloride in attention deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry 35:1314–1321

    PubMed  CAS  Google Scholar 

  33. Connor DF, Barkley RA, Davis HT (2000) A pilot study of methylphenidate, clonidine, or the combination in ADHD comorbid with aggressive oppositional defiant or conduct disorder. Clin Pediatr (Phila) 39:15–25

    CAS  Google Scholar 

  34. Connor DF, Fletcher KE, Swanson JM (1999) A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 38:1551–1559

    PubMed  CAS  Google Scholar 

  35. Crenshaw T, Kavale K, Forness S, Reeve R (1999) Attention deficit hyperactivity disorder and the efficacy stimulant medication: a meta-analysis. In: TE S, MA M (eds) Advances in learning and behavioral disabilities. JAI Press, Greenwich, CT, pp 135–136

    Google Scholar 

  36. Denckla MB, Bemporad JR, MacKay MC (1976) Tics following methylphenidate administration. A report of 20 cases. JAMA 235:1349–1351

    PubMed  CAS  Google Scholar 

  37. Döpfner M, Rothenberger A (2007) Behavior therapy in tic disorders with ADHD. Eur Child Adolesc Psychiatry 16(Suppl 1):I/89–I/99

    Google Scholar 

  38. Efron D, Jarman F, Barker M (1997) Methylphenidate versus dexamphetamine in children with attention deficit hyperactivity disorder: a double-blind, crossover trial. Pediatrics 100:E6

    PubMed  CAS  Google Scholar 

  39. Ekman JT, Gustafsson PA (2000) Stimulants in AD/HD, a controversial treatment only in Sweden? Eur Child Adolesc Psychiatry 9:312–313

    PubMed  CAS  Google Scholar 

  40. Elia J, Borcherding BG, Rapoport JL, Keysor CS (1991) Methylphenidate and dextroamphetamine treatments of hyperactivity: are there true nonresponders? Psychiatry Res 36:141–155

    PubMed  CAS  Google Scholar 

  41. Erenberg G, Cruse RP, Rothner AD (1985) Gilles de la Tourette’s syndrome: effects of stimulant drugs. Neurology 35:1346–1348

    PubMed  CAS  Google Scholar 

  42. Feigin A, Kurlan R, McDermott MP, Beach J, Dimitsopulos T, Brower CA, Chapieski L, Trinidad K, Como P, Jankovic J (1996) A controlled trial of deprenyl in children with Tourette’s syndrome and attention deficit hyperactivity disorder. Neurology 46:965–968

    PubMed  CAS  Google Scholar 

  43. Fras I, Karlavage J (1977) The use of methylphenidate and imipramine in Gilles de la Tourette’s disease in children. Am J Psychiatry 134:195–197

    PubMed  CAS  Google Scholar 

  44. Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P (2000) An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol 42:436–447

    PubMed  CAS  Google Scholar 

  45. Freeman RD, Tourette Syndrome International Database Consortium (2007) Tic disorders and ADHD – answers from a world-wide clinical data set on Tourette Syndrome. Eur Child Adolesc Psychiatry 16(Suppl 1):I/15–I/23

    Google Scholar 

  46. Gadow KD, Sverd J, Sprafkin J, Nolan EE, Ezor SN (1995) Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. Arch Gen Psychiatry 52:444–455

    PubMed  CAS  Google Scholar 

  47. Gadow KD, Sverd J, Sprafkin J, Nolan EE, Grossman S (1999) Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. Arch Gen Psychiatry 56:330–336

    PubMed  CAS  Google Scholar 

  48. Gilbert DL (2006) Motor cortex inhibitory function in Tourette syndrome, attention deficit disorder, and obsessive compulsive disorder: studies using transcranial magnetic stimulation. Adv Neurol 99:107–114

    PubMed  Google Scholar 

  49. Golden GS (1974) Gilles de la Tourette’s syndrome following methylphenidate administration. Dev Med Child Neurol 16:76–78

    PubMed  CAS  Google Scholar 

  50. Greenhill LL, Biederman J, Boellner SW, Rugino TA, Sangal RB, Earl CQ, Jiang JG, Swanson JM (2006) A randomized, double-blind, placebo-controlled study of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 45:503–511

    PubMed  Google Scholar 

  51. Greenhill LL, Pliszka S, Dulcan MK, Bernet W, Arnold V, Beitchman J, Benson RS, Bukstein O, Kinlan J, McClellan J, Rue D, Shaw JA, Stock S (2002) Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 41:26S–49S

    PubMed  Google Scholar 

  52. Hazell PL, Stuart JE (2003) A randomized controlled trial of clonidine added to psychostimulant medication for hyperactive and aggressive children. J Am Acad Child Adolesc Psychiatry 42:886–894

    PubMed  Google Scholar 

  53. Heinrich H, Gevensleben H, Strehl U (2007) Annotation: neurofeedback – train your brain to train behaviour. J Child Adolesc Psychiatry 48:3–16

    Google Scholar 

  54. Horrigan JP, Barnhill LJ (1995) Guanfacine for treatment of attention-deficit hyperactivity disorder in boys. J Child Adolesc Psychopharmacol 5:215–223

    Google Scholar 

  55. Hunt RD (1987) Treatment effects of oral and transdermal clonidine in relation to methylphenidate: an open pilot study in ADD-H. Psychopharmacol Bull 23:111–114

    PubMed  CAS  Google Scholar 

  56. Hunt RD, Arnsten AF, Asbell MD (1995) An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 34:50–54

    PubMed  CAS  Google Scholar 

  57. Hunt RD, Minderaa RB, Cohen DJ (1985) Clonidine benefits children with attention deficit disorder and hyperactivity: report of a double-blind placebo-crossover therapeutic trial. J Am Acad Child Psychiatry 24:617–629

    PubMed  CAS  Google Scholar 

  58. Jadad AR, Boyle M, Cunningham C, Kim M, Schachar R (1999) Treatment of attention-deficit/hyperactivity disorder. Evid Rep Technol Assess (Summ):I–viii, 1–341

    Google Scholar 

  59. Kelsey DK, Sumner CR, Casat CD, Coury DL, Quintana H, Saylor KE, Sutton VK, Gonzales J, Malcolm SK, Schuh KJ, Allen AJ (2004) Once-daily atomoxetine treatment for children with attention-deficit/hyperactivity disorder, including an assessment of evening and morning behavior: a double-blind, placebo-controlled trial. Pediatrics 114:e1–e8

    PubMed  Google Scholar 

  60. Khalifa N, von Knorring AL (2003) Prevalence of tic disorders and Tourette syndrome in a Swedish school population. Dev Med Child Neurol 45:315–319

    PubMed  Google Scholar 

  61. Konofal E, Cortese S, Lecendreux M, Arnulf I, Mouren MC (2005) Effectiveness of iron supplementation in a young child with attention-deficit/hyperactivity disorder. Pediatrics 116:e732–734

    PubMed  Google Scholar 

  62. Kratochvil CJ, Wilens TE, Greenhill LL, Gao H, Baker KD, Feldman PD, Gelowitz DL (2006) Effects of long-term atomoxetine treatment for young children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 45:919–927

    PubMed  Google Scholar 

  63. Learned-Coughlin SM, Bergstrom M, Savitcheva I, Ascher J, Schmith VD, Langstrom B (2003) In vivo activity of bupropion at the human dopamine transporter as measured by positron emission tomography. Biol Psychiatry 54:800–805

    PubMed  CAS  Google Scholar 

  64. Lipkin PH, Goldstein IJ, Adesman AR (1994) Tics and dyskinesias associated with stimulant treatment in attention-deficit hyperactivity disorder. Arch Pediatr Adolesc Med 148:859–861

    PubMed  CAS  Google Scholar 

  65. Loo SK, Barkley RA (2005) Clinical utility of EEG in attention deficit hyperactivity disorder. Appl Neuropsychol 12:64–76

    PubMed  Google Scholar 

  66. Lowe TL, Cohen DJ, Detlor J, Kremenitzer MW, Shaywitz BA (1982) Stimulant medications precipitate Tourette’s syndrome. JAMA 247:1168–1169

    PubMed  CAS  Google Scholar 

  67. Lyon MR, Cline JC, Totosy de Zepetnek J, Shan JJ, Pang P, Benishin C (2001) Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. J Psychiatry Neurosci 26:221–228

    PubMed  CAS  Google Scholar 

  68. Mantovani A, Lisanby SH, Pieraccini F, Ulivelli M, Castrogiovanni P, Rossi S (2006) Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette’s syndrome (TS). Int J Neuropsychopharmacol 9:95–100

    PubMed  Google Scholar 

  69. Michelson D, Allen AJ, Busner J, Casat C, Dunn D, Kratochvil C, Newcorn J, Sallee FR, Sangal RB, Saylor K, West S, Kelsey D, Wernicke J, Trapp NJ, Harder D (2002) Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: a randomized, placebo-controlled study. Am J Psychiatry 159:1896–1901

    PubMed  Google Scholar 

  70. Michelson D, Faries D, Wernicke J, Kelsey D, Kendrick K, Sallee FR, Spencer T (2001) Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, dose–response study. Pediatrics 108:E83

    PubMed  CAS  Google Scholar 

  71. Mohammadi MR, Ghanizadeh A, Alaghband-Rad J, Tehranidoost M, Mesgarpour B, Soori H (2004) Selegiline in comparison with methylphenidate in attention deficit hyperactivity disorder children and adolescents in a double-blind, randomized clinical trial. J Child Adolesc Psychopharmacol 14:418–425

    PubMed  Google Scholar 

  72. Motavalli Mukaddes N, Abali O (2004) Venlafaxine in children and adolescents with attention deficit hyperactivity disorder. Psychiatry Clin Neurosci 58:92–95

    Google Scholar 

  73. Mousain-Bosc M, Roche M, Rapin J, Bali JP (2004) Magnesium VitB6 intake reduces central nervous system hyperexcitability in children. J Am Coll Nutr 23:545S–548S

    PubMed  Google Scholar 

  74. MTA Cooperative Group (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1073–1086

    Google Scholar 

  75. Niederhofer H, Staffen W, Mair A (2003) A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. J Psychopharmacol 17:113–119

    PubMed  CAS  Google Scholar 

  76. Nogovitsina OR, Levitina EV (2005) Diagnostic value of examination of the magnesium homeostasis in children with attention deficit syndrome with hyperactivity. [Russian] Klin Lab Diagn, May 5:17–19

    Google Scholar 

  77. Nogovitsina OR, Levitina EV (2006) Effect of MAGNE-B6 on the clinical and biochemical manifestations of the syndrome of attention deficit and hyperactivity in children. Eksp Klin Farmakol 69:74–77

    PubMed  CAS  Google Scholar 

  78. Olvera RL, Pliszka SR, Luh J, Tatum R (1996) An open trial of venlafaxine in the treatment of attention-deficit/hyperactivity disorder in children and adolescents. J Child Adolesc Psychopharmacol 6:241–250

    PubMed  CAS  Google Scholar 

  79. Piacentini J, Chang S (2001) Behavioral treatments for Tourette syndrome and tic disorders: State of the art. Adv Neurology 85:319–331

    CAS  Google Scholar 

  80. Pliszka SR, Crismon ML, Hughes CW, Corners CK, Emslie GJ, Jensen PS, McCracken JT, Swanson JM, Lopez M (2006) The Texas Children’s Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 45:642–657

    PubMed  Google Scholar 

  81. Prince JB, Wilens TE, Biederman J, Spencer TJ, Millstein R, Polisner DA, Bostic JQ (2000) A controlled study of nortriptyline in children and adolescents with attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 10:193–204

    PubMed  CAS  Google Scholar 

  82. Ratner S, Laor N, Bronstein Y, Weizman A, Toren P (2005) Six-week open-label reboxetine treatment in children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 44:428–433

    PubMed  Google Scholar 

  83. Robertson MM (2006) Attention deficit hyperactivity disorder, tics and Tourette’s syndrome: the relationship and treatment implications. A commentary. Eur Child Adolesc Psychiatry 15:1–11

    PubMed  Google Scholar 

  84. Roessner V, Banaschewski T, Rothenberger A (2004) Therapie der Tic-Störungen (Therapy of tic-disorders). Z Kinder Jugendpsychiatr Psychother 32:245–263

    PubMed  Google Scholar 

  85. Roessner V, Robatzek M, Knapp G, Banaschewski T, Rothenberger A (2006) First-onset tics in patients with attention-deficit-hyperactivity disorder: impact of stimulants. Develop Med Child Neurol 48: 616–621

    PubMed  Google Scholar 

  86. Roessner V, Becker A, Banaschewski T, Rothenberger A (2007a) Executive functions in children with chronic tic disorders with/without ADHD – new insights. Eur Child Adolesc Psychiatry 16(Suppl 1):I/36–I/44

    Google Scholar 

  87. Roessner V, Becker A, Banaschewski T, Freeman RD, Rothenberger A, Tourette Syndrome International Database Consortium (2007) Developmental psychopathology of children and adolescents with Tourette syndrome - impact of ADHD. Eur Child Adolesc Psychiatry 16(Suppl 1):I/24–I/35

    Google Scholar 

  88. Sagvolden T, Johansen EB, Aase H, Russell VA (2005) A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. Behav Brain Sci 28:397–419; Discussion 419–368

    PubMed  Google Scholar 

  89. Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E, Arnsten AF, Cohen DJ, Leckman JF (2001) A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry 158:1067–1074

    PubMed  CAS  Google Scholar 

  90. Scahill L, Erenberg G, Berlin CM Jr, Budman C, Coffey BJ, Jankovic J, Kiessling L, King RA, Kurlan R, Lang A, Mink J, Murphy T, Zinner S, Walkup J (2006) Contemporary assessment and pharmacotherapy of Tourette syndrome. NeuroRx 3:192–206

    PubMed  CAS  Google Scholar 

  91. Scahill L, Schwab-Stone M (2000) Epidemiology of ADHD in school-age children. Child Adolesc Psychiatr Clin N Am 9:541–555, vii

    PubMed  CAS  Google Scholar 

  92. Scahill L, Williams S, Schwab-Stone M, Applegate J, Leckman JF (2006) Disruptive behavior problems in a community sample of children with tic disorders. Adv Neurol 99:184–190

    PubMed  Google Scholar 

  93. Scahill L, Sukhodolsky D, Bearss K, Findley D, Hamrin V, Rains A (2006) A randomized trial of parent management training in children with tic disorders and disruptive behavior. J Child Neurol 21:650–656

    PubMed  Google Scholar 

  94. Schachter HM, Pham B, King J, Langford S, Moher D (2001) How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis. CMAJ 165:1475–1488

    PubMed  CAS  Google Scholar 

  95. Sever Y, Ashkenazi A, Tyano S, Weizman A (1997) Iron treatment in children with attention deficit hyperactivity disorder. A preliminary report. Neuropsychobiology 35:178–180

    PubMed  CAS  Google Scholar 

  96. Shytle RD, Silver AA, Wilkinson BJ, Sanberg PR (2002) A pilot controlled trial of transdermal nicotine in the treatment of attention deficit hyperactivity disorder. World J Biol Psychiatry 3:150–155

    PubMed  Google Scholar 

  97. Singer HS, Brown J, Quaskey S, Rosenberg LA, Mellits ED, Denckla MB (1995) The treatment of attention-deficit hyperactivity disorder in Tourette’s syndrome: a double-blind placebo-controlled study with clonidine and desipramine. Pediatrics 95:74–81

    PubMed  CAS  Google Scholar 

  98. Smith BH, Waschbusch DA, Willoughby MT, Evans S (2000) The efficacy, safety, and practicality of treatments for adolescents with attention-deficit/hyperactivity disorder (ADHD). Clin Child Fam Psychol Rev 3:243–267

    PubMed  CAS  Google Scholar 

  99. Snyder SH, Taylor KM, Coyle JT, Meyerhoff JL (1970) The role of brain dopamine in behavioral regulation and the actions of psychotropic drugs. Am J Psychiatry 127:199–207

    PubMed  CAS  Google Scholar 

  100. Spencer T, Biederman J, Coffey B, Geller D, Crawford M, Bearman SK, Tarazi R, Faraone SV (2002) A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 59:649–656

    PubMed  CAS  Google Scholar 

  101. Spencer T, Biederman J, Steingard R, Wilens T (1993) Bupropion exacerbates tics in children with attention-deficit hyperactivity disorder and Tourette’s syndrome. J Am Acad Child Adolesc Psychiatry 32:211–214

    PubMed  CAS  Google Scholar 

  102. Spencer T, Biederman J, Wilens T, Steingard R, Geist D (1993) Nortriptyline treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette’s syndrome. J Am Acad Child Adolesc Psychiatry 32:205–210

    PubMed  CAS  Google Scholar 

  103. Spencer T, Heiligenstein JH, Biederman J, Faries DE, Kratochvil CJ, Conners CK, Potter WZ (2002) Results from 2 proof-of-concept, placebo-controlled studies of atomoxetine in children with attention-deficit/hyperactivity disorder. J Clin Psychiatry 63:1140–1147

    PubMed  CAS  Google Scholar 

  104. Sukhodolsky D, Scahill L, Zhang H, Peterson BS, King RA, Lombroso PJ, Katsovich L, Findley D, Leckman JF (2003) Disruptive behavior in children with Tourette’s Syndrome: Association of ADHD comorbidity, tic severity, and functional impairment. J Am Acad Child Adolesc Psychiatry 42:98–105

    PubMed  Google Scholar 

  105. Swanson JM, Greenhill LL, Lopez FA, Sedillo A, Earl CQ, Jiang JG, Biederman J (2006) Modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation. J Clin Psychiatry 67:137–147

    PubMed  CAS  Google Scholar 

  106. Taylor E, Dopfner M, Sergeant J, Asherson P, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Rothenberger A, Sonuga-Barke E, Steinhausen HC, Zuddas A (2004) European clinical guidelines for hyperkinetic disorder – first upgrade. Eur Child Adolesc Psychiatry 13(Suppl 1):I7–30

    PubMed  Google Scholar 

  107. Tourette Syndrome Study Group (2002) Treatment of ADHD in children with tics: a randomized controlled trial. Neurology 58(4):527–536

    Google Scholar 

  108. Van Oudheusden LJ, Scholte HR (2002) Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 67:33–38

    PubMed  Google Scholar 

  109. Varley CK (2001) Sudden death related to selected tricyclic antidepressants in children: epidemiology, mechanisms and clinical implications. Paediatr Drugs 3:613–627

    PubMed  CAS  Google Scholar 

  110. Weiss M, Tannock R, Kratochvil C, Dunn D, Velez-Borras J, Thomason C, Tamura R, Kelsey D, Stevens L, Allen AJ (2005) A randomized, placebo-controlled study of once-daily atomoxetine in the school setting in children with ADHD. J Am Acad Child Adolesc Psychiatry 44:647–655

    PubMed  Google Scholar 

  111. Wilens TE, Waxmonsky J, Scott M, Swezey A, Kwon A, Spencer TJ, Biederman J (2005) An open trial of adjunctive donepezil in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 15:947–955

    PubMed  Google Scholar 

  112. Wilhelm S, Deckersbach T, Coffey BJ, Bohne A, Peterson AL, Baer L (2003) Habit reversal versus supportive psychotherapy for Tourette’s disorder: a randomized controlled trial. Am J Psychiatry 160(6):1175–1171

    PubMed  Google Scholar 

  113. Woods DW, Twohig MP, Flessner CA, Roloff TJ (2003) Treatment of vocal tics in children with Tourette syndrome: investigating the efficacy of habit reversal. J Appl Behav Anal 36(1):109–112

    PubMed  Google Scholar 

  114. Young GS, Conquer JA, Thomas R (2005) Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. Reprod Nutr Dev 45:549–558

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lawrence Scahill MSN, Ph.D..

Rights and permissions

Reprints and permissions

About this article

Cite this article

Poncin, Y., Sukhodolsky, D.G., McGuire, J. et al. Drug and non-drug treatments of children with ADHD and tic disorders. Eur Child Adolesc Psychiatry 16 (Suppl 1), 78–88 (2007). https://doi.org/10.1007/s00787-007-1010-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00787-007-1010-8

Keywords

Navigation