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Slower cortisol response during ACTH stimulation test in autistic children

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Abstract

Autism is a hereditary, pervasive neurodevelopmental disorder that starts early in life. The main characteristics of the autism are impairment in social interactions, difficulties in adapting to novel environmental situations and improper reaction to stress. Since the Hypothalamic-Pituitary-Adrenocortical (HPA) axis plays a key role in the response to stress and because the previous research found abnormalities in HPA system, we conducted a study to test several elements of the HPA axis. Because autism is a heritable disorder, autistic subjects were studied as well as their parents. Cortisol circadian rhythm, cortisol daily secretion and its suppression response to dexamethason had been measured from saliva or urine samples of the autistic children and their parents. Cortisol secretion response after ACTH stimulation was done with the autistic children only. The cortisol elevation after ACTH stimulation among the autistic individuals was slower (P = 0.017) than in healthy controls. No differences were found in salivary cortisol circadian rhythm or suppression response, as well as in cortisol daily excretion. These data indicate that, compared to healthy subjects, autistic individuals have fine differences in cortisol response to ACTH stimulation or possibly to other types of stress.

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Acknowledgement

We thank to all the children with autism and parents that participated in the study. Also, we are very thankful to the personnel of the «Center for Autism» in Split and Zagreb.

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Authors and Affiliations

  1. Department of Psychiatry, Clinical Hospital Split, Split, Croatia

    Jasna Marinović-Ćurin

  2. Department of Physiology, School of Medicine, University of Split, Šoltanska 2, Split , 21000, Croatia

    Ivana Marinović-Terzić, Zoran Đogaš & Janoš Terzić

  3. Psychiatric hospital for children and adolescents, Kukuljeviceva, Zagreb, Croatia

    Zorana Bujas-Petković

  4. Department of Nuclear Medicine, Clinical Hospital Split, Split, Croatia

    Ljubinka Zekan

  5. Department of Pediatrics, Clinical Hospital Split, Split, Croatia

    Veselin Škrabić

Authors
  1. Jasna Marinović-Ćurin
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  2. Ivana Marinović-Terzić
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  3. Zorana Bujas-Petković
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  4. Ljubinka Zekan
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  5. Veselin Škrabić
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  6. Zoran Đogaš
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  7. Janoš Terzić
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Correspondence to Janoš Terzić.

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Marinović-Ćurin, J., Marinović-Terzić, I., Bujas-Petković, Z. et al. Slower cortisol response during ACTH stimulation test in autistic children. Eur Child Adolesc Psychiatry 17, 39–43 (2008). https://doi.org/10.1007/s00787-007-0632-1

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  • DOI: https://doi.org/10.1007/s00787-007-0632-1

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