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No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes

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Abstract.

Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of whom had comorbid ADHD.No evidence of either association or linkage disequilibrium was found, neither in the total sample nor in the comorbid subgroup. Negative results do not support a common genetic basis between these two disorders for these markers.

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Authors and Affiliations

  1. Scientific Institute "Eugenio Medea", Department of Child Psychiatry, Don L.Monza 20, 23842, Bosisio Parini (LC), Italy

    C. Marino, L. Vanzin, M. Molteni, M. L. Lorusso, M. Nobile & M. Battaglia

  2. Molecular Biology Laboratory, Don L.Monza 20, 23842, Bosisio Parini (LC), Italy

    R. Giorda & C. Baschirotto

  3. Dalhousie University, Department of Psychiatry, Halifax, Abbie J. Lane, Building 5909, Jubilee Road, Halifax, Nova Scotia, B3H 2E2, Canada

    M. Alda

  4. Department of Psychology, San Raffaele Vita-Salute University, Milan, Italy

    M. Battaglia

  5. Scientific Institute San Raffaele Milan, Department of Neuropsychiatric Sciences, Stamira d’Ancona 20, Milan, Italy

    M. Battaglia

Authors
  1. C. Marino
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  2. R. Giorda
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  3. L. Vanzin
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  4. M. Molteni
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  5. M. L. Lorusso
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  6. M. Nobile
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  7. C. Baschirotto
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  8. M. Alda
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  9. M. Battaglia
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Corresponding author

Correspondence to C. Marino.

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Marino, C., Giorda, R., Vanzin, L. et al. No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes. European Child & Adolescent Psychiatry 12, 198–202 (2003). https://doi.org/10.1007/s00787-003-0332-4

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  • DOI: https://doi.org/10.1007/s00787-003-0332-4

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