Abstract
Objective
The aim of this study was to analyze the postoperative effects of intra-alveolar applications of 0.2% chlorhexidine (CHL) or 1% hyaluronic (HA) acid bioadhesive gels following the extraction of mandibular impacted third molars (MITMs).
Materials and methods
In this double-blind randomized controlled clinical trial, 90 patients with one asymptomatic MITM were randomized into three group (n = 30 per group): group 1 (0.2% CHL), group 2 (1% HA), and group 3 (control). Visual analogue scales (VAS) were used to assess postoperative pain 24, 48, and 72 h and 7 days after surgery. Postsurgical complications were recorded: trismus, alveolitis osteitis, infection, or hematoma.
Results
In order from least to greatest, postoperative pain at all evaluation times was 0.2% CHL < 1% HA < control. At 24 h, statistically significant differences were found between both study groups and the control groups (0.2% CHL/control: P = 0.001; 1% HA/control: P = 0.010). At 48 and 72 h, significant differences were only found between 0.2% CHL and the control group (P = 0.229 and P = 0.046, respectively). At 7 days, no significant differences were found between any groups. Comparing the incidence of postoperative trismus, alveolitis osteitis, infection, or hematoma, although complications were more frequent in the control group, no statistical differences between groups were found (P > 0.050).
Conclusions
Both 0.2% CHL and 1% HA bioadhesive gels applied intra-alveolarly minimize the postoperative complications after MITM extraction. Further research is necessary to confirm the present results.
Clinical relevance
This study might help to reduce the postsurgical complications in patients after MITM extraction.
Similar content being viewed by others
References
Toedtling V, Devlin H, O'Malley L, Tickle M (2020) A systematic review of second distal surface caries incidence in the context of third molar absence and emergence. Br Dent J 228:261–266
Yamalik K, Bozkaya S (2008) The predictivity of mandibular third molar position as a risk indicator for pericoronaritis. Clin Oral Invetig 12:9–14
Coello-Gómez A, Navarro-Suárez S, Diosdado-Cano JM, Azcárate-Velazquez F, Bargiela-Pérez P, Serrera-Figallo MA et al (2018) Postoperative effects on lower third molars using mouthwashes with super-oxidized solution versus 0.2% chlorhexidine gel: a randomized double-blind trial. Med Oral Patol Oral Ciru Bucal 23:e716–e722
(1980) NIH consensus development conference for removal of third molars. J Oral Surg 38:235–236
McArdle LW, Renton T (2012) The effects of NICE guidelines on the management of third molar teeth. Br Dent J 213:E8
Lee CT, Zhang S, Leung YY, Li SK, Tsang CC, Chu CH (2015) Patient’s satisfaction and prevalence of complications on surgical extraction of third molar. Patient Prefer Adherence 9:257–263
Brkić A, Mutlu S, Koçak-Berberoğlu H, Olgaç V (2010) Pathological changes and immunoexpression of p63 gene in dental follicles of asymptomatic impacted lower third molars: an immunohistochemical study. J Craniofac Surg 21:854–857
Cabbar F, Güler N, Comunoğlu N, Sençift K, Cöloğlu S (2008) Determination of potential cellular proliferation in the odontogenic epithelia of the dental follicle of asymptomatic impacted third molars. J Oral Maxillofac Surg 66:2004–2011
Camacho-Alonso F, Tudela-Mulero MR, Peñarrocha-Oltra D, Peñarrocha-Diago M, Balaguer-Martí JC, Sánchez-Siles M (2019) Salivary myeloperoxidase and malondialdehyde are increased in patients exhibiting an asymptomatic mandibular impacted third molar. Med Oral Patol Oral Cir Bucal 24:e537–e544
Bouloux GF, Steed MB, Perciaccante VJ (2007) Complications of third molar surgery. Oral Maxillofac Surg Clin North Am 19:117–128
Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M (2019) Complication in third molar extractions. J Biol Regul Homeost Agents 33:169–172
Olate S, Assis A, Freire S, de Moraes M, de Albergaria-Barbosa JR (2013) Facial and cervical emphysema after oral surgery: a rare case. Int J Clin Exp Med 25:840–844
Vasconcelos BC, Bessa-Nogueira RV, Maurette PE, Carneiro SC (2006) Facial nerve paralysis after impacted lower third molar surgery: a literature review and case report. Med Oral Patol Oral Cir Bucal 11:E175–E178
Larsen MK, Kofod T, Starch-Jensen T (2019) Therapeutic efficacy of cryotherapy on facial swelling, pain, trismus and quality of life after surgical removal of mandibular third molars: a systematic review. J Oral Rehabil 46:563–573
Koparal M, Kucuk AO, Alan H, Asutay F, Avci M (2018) Effects of low-level laser therapy following surgical extraction of the lower third molar with objective measurement of swelling using a three-dimensional system. Exp Ther Med 15:3820–3826
Sivalingam VP, Panneerselvam E, Raja KV, Gopi G (2017) Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? A randomized controlled trial. J Oral Maxillofac Surg 75:51.e1-9
Xiang X, Shi P, Zhang P, Shen J, Kang J (2019) Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis. BMC Oral Health 19:163
Madrazo-Jiménez M, Rodríguez-Caballero Á, Serrera-Figallo MÁ, Garrido-Serrano R, Gutiérrez-Corrales A, Gutiérrez-Pérez JL et al (2016) The effects of topical gel containing chitosan, 0,2% chlorhexidine, allantoin, and despanthenol on the wound healing process subsequent to impacted lower third molar extraction. Med Oral Patol Oral Cir Bucal 21:e696–e702
Sridhar V, Wali GG, Shyla HN (2011) Evaluation of the perioperative use of 0.2% chlorhexidine gluconate for the prevention of alveolar osteitis after the extraction of impacted mandibular third molars: a clinical study. J Maxillofac Oral Sug 10:101–111
Rubio-Palau J, Garcia-Linares J, Huerto-Madrid JA, González-Lagunas J, Raspall-Martin G, Mareque-Bueno J (2015) Effect of intra-alveolar placement of 0.2% chlorhexidine gel on the incidence of alveolar osteitis following the extraction of mandibular third molars. A double-blind randomized clinical trial. Med Oral Patol Oral Cir Bucal 20:e117–e122
Torres-Lagares D, Infante Cossio P, Gutierrez-Perez JL, Romero-Ruiz MM, Garcia-Calderon M, Serrera-Figallo MA (2006) Intra-alveolar chlorhexidine gel for prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal 11:E179–E184
Rodríguez-Pérez M, Bravo-Pérez M, Sánchez-López JD, Muñoz-Soto E, Romero-Olid MN, Baca-García P (2013) Effectiveness of 1% versus 0.2% chlorhexidine gels in reducing alveolar osteitis from mandibular third molar surgery: a randomized, double-blind clinical trial. Med Oral Patol Oral Cir Bucal 18:693–700
Gocmen G, Aktop S, Tüzüner B, Goker B, Yarat A (2017) Effects of hyaluronic acid on bleeding following third molar extraction. J Appl Oral Sci 25:211–216
Guazzo R, Perissinotto E, Mazzoleni S, Ricci S, Peñaroocha-Oltra D, Sivolella S (2018) Effect on wound healing of a topical gel containing amino acid and sodium hyaluronate applied to the alveolar socket after mandibular third molar extraction: a double-blind randomized controlled trial. Quintessence Int 49:831–840
Jones CG (1997) Chlorhexidine: is it still the gold standard? Peridontol 2000(15):55–62
EM MC, Goldenberg RL, Brandes N, Darmstadt GL, Wright LL, CHL Working Group Ambruster D et al (2007) The use of chlorhexidine to reduce maternal and neonatal mortality and morbidity in low-resource settings. Int J Gynaecol Obstet 97:89–94
Jiang D, Liang J, Noble PW (2007) Hyaluronan in tissue injury repair. Annu Rev Cell Dev Biol 23:435–461
Nolan A, Badminton J, Maguire J, Seymour RA (2009) The efficacy of topical hyaluronic acid in the management of oral lichen planus. J Oral Pathol Med 38:299–303
Nakanishi T, Kaiho F, Hayashi M (1998) Improvement of drug release rate from carbopol 934P formulation. Chem Pharm Bull (Tokyo) 46:171–173
Pederson GW. Oral Surgery. Philadelphia: WB Suanders, 1988. Cited in Koerner KR (1994) the removal of impacted third molars. Principles and procedures. Dent Clin N Am 38:255–278
Diniz-Freitas M, Lago-Méndez L, Gude-Sampedro F, Somoza-Martin JM, Gándara-Rey JM, García-García A (2007) Pederson scale fails to predict how difficult it will be to extract lower third molars. Br J Oral Maxillofac Surg 45:23–26
Blum IR (2002) Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg 31:309–317
Bello SA, Olaitan AA, Ladeine AL (2011) A randomized comparison of the effect of partial and total wound closure techniques on postoperative morbidity after mandibular third molar surgery. J Oral Maxillofac Surg 69:e24–e30
Tenis CA, Martins MD, Gonçalves MLL, Silva DFTD, Cunha Filho JJD, Martins MAT et al (2018) Efficacy of diode-emitting diode (LED) photobiomodulation in pain management, facial edema, trismus, and quality of life after extraction of retained lower third molars: a randomized, double-blind, placebo-controlled clinical trial. Biomedicine (Baltimore) 97:e12264
Arteagoitia MI, Barbier L, Santamaría J, Santamaría G, Ramos E (2016) Efficacy of amoxicillin and amoxicillin/clavulanic acid in prevention of infection and dry socket after third molar extraction. A systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal 21:e494–e504
Menon RK, Gopinath D, Li KY, Leung YY, Botelho MG (2018) Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review and meta-analysis. Int J Oral Maxillofac Surg 48:263–273
Lodi G, Figini L, Sardella A, Carrassi A, Del Fabbro M, Furness S (2012) Antibiotics to prevent complications following tooth extractions. Cochrane Database Syst Rev 11:CD003811
Shuborna NS, Chaiyasamut T, Sakdajeyont W, Vokakuplipat C, Rojvanakarn M, Wongsirichat N (2019) Generation of novel hyaluronic acid biomaterials for study of pain in third molar intervention: a review. J Dent Anesth Pain Med 19:11–19
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
The study protocol was approved by the University of Murcia Ethics Committee (2650/2019).
Informed consent
All patients signed an informed consent to take part in the study.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Muñoz-Cámara, D., Pardo-Zamora, G. & Camacho-Alonso, F. Postoperative effects of intra-alveolar application of 0.2% chlorhexidine or 1% hyaluronic acid bioadhesive gels after mandibular third molar extraction: a double-blind randomized controlled clinical trial. Clin Oral Invest 25, 617–625 (2021). https://doi.org/10.1007/s00784-020-03522-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00784-020-03522-y