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The assessment of stress, depression, and inflammation as a collective risk factor for periodontal diseases: a systematic review

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Abstract

Objectives

The purpose of this review was to provide a novel perspective utilizing an assessment of biomarkers to evaluate the impact of stress-related disorders on the progression of periodontal disease and evaluate the growing body of evidence of stress as a risk indicator for periodontal disease progression.

Methods

Cross-sectional, case-control, and biomarker studies associating psychological disorders and periodontal disease were included in the literature search. Computational studies, animal studies, reviews, and studies lacking healthy controls were excluded. Electronic and manual literature searches were conducted by two independent reviewers in several databases as well as a manual search for relevant articles published up to January 2018.

Results

Twenty-six articles fulfilled the inclusion criteria and were included in the qualitative synthesis. Relationships between stress-related disorders and serum and salivary biomarkers such as cortisol, dehydroepiandrosterone (DHEA), chromogranin A (CgA), and pro-inflammatory cytokines were identified.

Conclusions

The use of salivary pro-inflammatory cytokines alone is not sufficient for the identification of periodontal disease severity/progression with or without the presence of stress-associated diseases. Keeping in mind the limitations of this review, a positive qualitative correlation was observed in the literature among stress-related biomarkers and the severity of periodontal disease. This correlation may serve as an important reporter of patient susceptibility for periodontal breakdown in the future.

Clinical relevance

Stress-related disorders should be included in the list of globally screened diseases because it can change the biochemistry of both the local periodontal microenvironment as well as the global systemic inflammatory burden.

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Funding

This paper was partially supported by the University of Michigan Periodontal Graduate Student Research Fund. AMD is funded by the Tissue Engineering and Regenerative Medicine fellowship (5T32DE007057-42).

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Authors and Affiliations

  1. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA

    Ann Decker, Houssam Askar & Mustafa Tattan

  2. Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USA

    Russell Taichman

  3. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA

    Hom-Lay Wang

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  1. Ann Decker
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Correspondence to Hom-Lay Wang.

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Decker, A., Askar, H., Tattan, M. et al. The assessment of stress, depression, and inflammation as a collective risk factor for periodontal diseases: a systematic review. Clin Oral Invest 24, 1–12 (2020). https://doi.org/10.1007/s00784-019-03089-3

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