Abstract
Objectives
Actually, there is no detailed guidance on how to deal with wound closure after surgical removal of medication-related osteonecrosis of the jaw (MRONJ) lesions. This study attempts to compare the difference in outcome between the mucosal and the mucoperiosteal flap closure after surgery.
Patients and methods
In this retrospective monocentric cohort study, patients (n = 61; 35 female/26 male) suffering from MRONJ and requiring surgical therapy at the University of Aachen between 2013 and 2015 were included. Due to intra-institutional variances, one group was treated with the mucosal, the other group with the mucoperiosteal technique. The success rate, i.e., mucosal closure and no relapse at the point of follow-up, was evaluated and compared. All patients were clinically investigated for the postoperative follow-up during a special consultation appointment.
Results
The success rates between the different techniques after 2 years follow-up were very similar. In the group of mucosal wound closure, 22 of 29 (75.86%) patients revealed mucosal integrity without signs of MRONJ. The rate in the mucoperiosteal wound closure group was almost identical (24 of 32 (75%)).
Conclusion
No differences in the success rates between the two different techniques could be evaluated.
Clinical relevance
The results of this study suggest that the complete removal of the necrotic bone might have a higher impact on the success rates than the technique of the wound closure. Due to the fact that the mucoperiosteal wound closure technique offers a better overview of the extent of the MRONJ lesion, the authors advise to use this technique.
Similar content being viewed by others
References
Berenson JR, Lichtenstein A, Porter L, Dimopoulos MA, Bordoni R, George S, Lipton A, Keller A, Ballester O, Kovacs MJ, Blacklock HA, Bell R, Simeone J, Reitsma DJ, Heffernan M, Seaman J, Knight RD (1996) Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 334(8):488–493. https://doi.org/10.1056/nejm199602223340802
Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, Bauer DC, Genant HK, Haskell WL, Marcus R, Ott SM, Torner JC, Quandt SA, Reiss TF, Ensrud KE (1996) Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 348(9041):1535–1541
Park JB, Cho SH, Kim I, Lee W, Kang SH, Kim H (2017) Evaluation of the bisphosphonate effect on stem cells derived from jaw bone and long bone rabbit models: a pilot study. Arch Oral Biol 85:178–182. https://doi.org/10.1016/j.archoralbio.2017.10.024
Ristow O, Gerngross C, Schwaiger M, Hohlweg-Majert B, Kehl V, Jansen H, Hahnefeld L, Otto S, Pautke C (2014) Is bone turnover of jawbone and its possible over suppression by bisphosphonates of etiologic importance in pathogenesis of bisphosphonate-related osteonecrosis? J Oral Maxillof Surg Off J Am Assoc Oral Maxillof Surg 72(5):903–910. https://doi.org/10.1016/j.joms.2013.11.005
Yoshimura H, Ohba S, Yoshida H, Saito K, Inui K, Yasui R, Ichikawa D, Aiki M, Kobayashi J, Matsuda S, Imamura Y, Sano K (2017) Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: a case report and literature review. Oncol Lett 14(1):127–136. https://doi.org/10.3892/ol.2017.6121
Egloff-Juras C, Gallois A, Salleron J, Massard V, Dolivet G, Guillet J, Phulpin B (2017) Denosumab-related osteonecrosis of the jaw: a retrospective study. J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol. https://doi.org/10.1111/jop.12646
American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws (2007). J Oral Maxillof Surg Off J Am Assoc Oral Maxillof Surg 65(3):369–376. https://doi.org/10.1016/j.joms.2006.11.003
Holzinger D, Seemann R, Klug C, Ewers R, Millesi G, Baumann A, Wutzl A (2013) Long-term success of surgery in bisphosphonate-related osteonecrosis of the jaws (BRONJs). Oral Oncol 49(1):66–70. https://doi.org/10.1016/j.oraloncology.2012.07.008
Otto S, Schreyer C, Hafner S, Mast G, Ehrenfeld M, Sturzenbaum S, Pautke C (2012) Bisphosphonate-related osteonecrosis of the jaws—characteristics, risk factors, clinical features, localization and impact on oncological treatment. J Cranio-maxillo-facial Surg Off Publ Eur Assoc Cranio-Maxillo-Facial Surg 40(4):303–309. https://doi.org/10.1016/j.jcms.2011.05.003
Wutzl A, Pohl S, Sulzbacher I, Seemann R, Lauer G, Ewers R, Drach J, Klug C (2012) Factors influencing surgical treatment of bisphosphonate-related osteonecrosis of the jaws. Head Neck 34(2):194–200. https://doi.org/10.1002/hed.21708
Carlson ER, Basile JD (2009) The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillof Surg Off J Am Assoc Oral Maxillofac Surg 67(5 Suppl):85–95. https://doi.org/10.1016/j.joms.2009.01.006
Ristow O, Otto S, Troeltzsch M, Hohlweg-Majert B, Pautke C (2015) Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ). J Cranio-maxillo-facial Surg Off Publ Eur Assoc Cranio-Maxillo-Facial Surg 43(2):290–293. https://doi.org/10.1016/j.jcms.2014.11.014
Lopes RN, Rabelo GD, Rocha AC, Carvalho PA, Alves FA (2015) Surgical therapy for bisphosphonate-related osteonecrosis of the jaw: six-year experience of a single institution. J Oral Maxillof Surg Off J Am Assoc Oral Maxillof Surg 73(7):1288–1295. https://doi.org/10.1016/j.joms.2015.01.008
Bedogni A, Saia G, Bettini G, Tronchet A, Totola A, Bedogni G, Ferronato G, Nocini PF, Blandamura S (2011) Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis. Oral Oncol 47(5):420–424. https://doi.org/10.1016/j.oraloncology.2011.02.024
K.A.Grötz J-UP Al Nawas (2012) Bisphosphonat-assoziierte Kiefernekrose (BP-ONJ) und andere Medikamenten-assoziierte Kiefernekrosen.18
AAOMS (2007) American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 65(3):369–376. https://doi.org/10.1016/j.joms.2006.11.003
Stockmann P, Vairaktaris E, Wehrhan F, Seiss M, Schwarz S, Spriewald B, Neukam FW, Nkenke E (2010) Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up. Supp Care Cancer Off J Multinatl Assoc Supp Care Cancer 18(4):449–460. https://doi.org/10.1007/s00520-009-0688-1
Wilde F, Heufelder M, Winter K, Hendricks J, Frerich B, Schramm A, Hemprich A (2011) The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111(2):153–163. https://doi.org/10.1016/j.tripleo.2010.04.015
Graziani F, Vescovi P, Campisi G, Favia G, Gabriele M, Gaeta GM, Gennai S, Goia F, Miccoli M, Peluso F, Scoletta M, Solazzo L, Colella G (2012) Resective surgical approach shows a high performance in the management of advanced cases of bisphosphonate-related osteonecrosis of the jaws: a retrospective survey of 347 cases. J Oral Maxillof Surg Off J Am Assoc Oral Maxillof Surg 70(11):2501–2507. https://doi.org/10.1016/j.joms.2012.05.019
Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B (2009) American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw—2009 update. Aust Endod J, J Aust Soc Endod Inc 35(3):119–130. https://doi.org/10.1111/j.1747-4477.2009.00213.x
Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F (2014) American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw—2014 update. J Maxillof Surg Off J Am Assoc Oral Maxillof Surg 72(10):1938–1956. https://doi.org/10.1016/j.joms.2014.04.031
Joda TGP, Ehmke B (2008) Arbeitshandbuch Parodontologie Band 2 Chirurgische Therapie. Books on Demand GmbH, Norderstedt, pp 11–99
Marx RE, Sawatari Y, Fortin M, Broumand V (2005) Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 63(11):1567–1575. https://doi.org/10.1016/j.joms.2005.07.010
Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL (2004) Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 62(5):527–534
Magopoulos C, Karakinaris G, Telioudis Z, Vahtsevanos K, Dimitrakopoulos I, Antoniadis K, Delaroudis S (2007) Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals. Am J Otolaryngol 28(3):158–163. https://doi.org/10.1016/j.amjoto.2006.08.004
Voss PJ, Joshi Oshero J, Kovalova-Muller A, Veigel Merino EA, Sauerbier S, Al-Jamali J, Lemound J, Metzger MC, Schmelzeisen R (2012) Surgical treatment of bisphosphonate-associated osteonecrosis of the jaw: technical report and follow up of 21 patients. J Cranio-Maxillo-Facial Surg Off Publ Eur Assoc Cranio-Maxillo-Facial Surg 40(8):719–725. https://doi.org/10.1016/j.jcms.2012.01.005
Hoefert S, Eufinger H (2011) Relevance of a prolonged preoperative antibiotic regime in the treatment of bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 69(2):362–380. https://doi.org/10.1016/j.joms.2010.06.200
Schubert M, Klatte I, Linek W, Muller B, Doring K, Eckelt U, Hemprich A, Berger U, Hendricks J (2012) The saxon bisphosphonate register—therapy and prevention of bisphosphonate-related osteonecrosis of the jaws. Oral Oncol 48(4):349–354. https://doi.org/10.1016/j.oraloncology.2011.11.004
Hoff AO, Toth BB, Altundag K, Johnson MM, Warneke CL, Hu M, Nooka A, Sayegh G, Guarneri V, Desrouleaux K, Cui J, Adamus A, Gagel RF, Hortobagyi GN (2008) Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res Off J Am Soc Bone Miner Res 23(6):826–836. https://doi.org/10.1359/jbmr.080205
Sven Otto M, DMD, FEBOMFS (2015) Medication-related osteonecrosis of the jaws Bisphosphonates, Denosumab and New Agents. Springer-Verlag Berlin, Heidelberg, pp 1–217
Rupel K, Ottaviani G, Gobbo M, Contardo L, Tirelli G, Vescovi P, Di Lenarda R, Biasotto M (2014) A systematic review of therapeutical approaches in bisphosphonates-related osteonecrosis of the jaw (BRONJ). Oral Oncol 50(11):1049–1057. https://doi.org/10.1016/j.oraloncology.2014.08.016
yKim HY, Lee SJ, Kim SM, Myoung H, Hwang SJ, Choi JY, Lee JH, Choung PH, Kim MJ, Seo BM (2017) Extensive surgical procedures result in better treatment outcomes for bisphosphonate-related osteonecrosis of the jaw in patients with osteoporosis. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 75(7):1404–1413. https://doi.org/10.1016/j.joms.2016.12.014
Fliefel R, Troltzsch M, Kuhnisch J, Ehrenfeld M, Otto S (2015) Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review. Int J Oral Maxillofac Surg 44(5):568–585. https://doi.org/10.1016/j.ijom.2015.01.026
Comas-Calonge A, Figueiredo R, Gay-Escoda C (2017) Surgical treatment vs. conservative treatment in intravenous bisphosphonate-related osteonecrosis of the jaws. Systematic review. J Clin Exp Dent 9(2):e302–e307. https://doi.org/10.4317/jced.53504
Mucke T, Koschinski J, Deppe H, Wagenpfeil S, Pautke C, Mitchell DA, Wolff KD, Holzle F (2011) Outcome of treatment and parameters influencing recurrence in patients with bisphosphonate-related osteonecrosis of the jaws. J Cancer Res Clin Oncol 137(5):907–913. https://doi.org/10.1007/s00432-010-0953-1
Wutzl A, Eisenmenger G, Hoffmann M, Czerny C, Moser D, Pietschmann P, Ewers R, Baumann A (2006) Osteonecrosis of the jaws and bisphosphonate treatment in cancer patients. Wien Klin Wochenschr 118(15–16):473–478. https://doi.org/10.1007/s00508-006-0644-8
Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B (2009) American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws—2009 update. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 67(5 Suppl):2–12. https://doi.org/10.1016/j.joms.2009.01.009
Marx RE (1983) Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg Off I Am Assoc Oral Maxillofac Surg 41(5):283–288
Pautke C, Tischer T, Neff A, Horch HH, Kolk A (2006) In vivo tetracycline labeling of bone: an intraoperative aid in the surgical therapy of osteoradionecrosis of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102(6):e10–e13. https://doi.org/10.1016/j.tripleo.2006.05.007
Ristow O, Otto S, Geiss C, Kehl V, Berger M, Troeltzsch M, Koerdt S, Hohlweg-Majert B, Freudlsperger C, Pautke C (2017) Comparison of auto-fluorescence and tetracycline fluorescence for guided bone surgery of medication-related osteonecrosis of the jaw: a randomized controlled feasibility study. Int J Oral Maxillofac Surg 46(2):157–166. https://doi.org/10.1016/j.ijom.2016.10.008
Pautke C, Bauer F, Otto S, Tischer T, Steiner T, Weitz J, Kreutzer K, Hohlweg-Majert B, Wolff KD, Hafner S, Mast G, Ehrenfeld M, Sturzenbaum SR, Kolk A (2011) Fluorescence-guided bone resection in bisphosphonate-related osteonecrosis of the jaws: first clinical results of a prospective pilot study. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 69(1):84–91. https://doi.org/10.1016/j.joms.2010.07.014
Otto S, Ristow O, Pache C, Troeltzsch M, Fliefel R, Ehrenfeld M, Pautke C (2016) Fluorescence-guided surgery for the treatment of medication-related osteonecrosis of the jaw: a prospective cohort study. J Cranio-Maxillo-Facial Surg Off Publ Eur Assoc Cranio-Maxillo-Facial Surg 44:1073–1080. https://doi.org/10.1016/j.jcms.2016.05.018
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
The study does not include any personal information of patients.
Informed consent
For this type of study formal consent is not required.
Rights and permissions
About this article
Cite this article
Nonnenmühlen, N., Burnic, A., Bartella, A. et al. Comparison of mucosal and mucoperiosteal wound cover for the treatment of medication-related osteonecrosis of the jaw lesions: a retrospective cohort study. Clin Oral Invest 23, 351–359 (2019). https://doi.org/10.1007/s00784-018-2443-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00784-018-2443-9