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A retrospective study of osteomyelitis and osteonecrosis of the jaws and its etiologic implication of bisphosphonate in Asians

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Abstract

Objective

The objective of this study were to find the annual case trend of inflammatory jawbone diseases and to investigate the impact of medication-related osteonecrosis of the jaws (MRONJ).

Material and methods

A retrospective study of 372 patients diagnosed with inflammatory jawbone condition except for alveolar osteitis from 2007 to 2015 was initiated. History taking and investigation of etiologic factors MRONJ, osteoradionecrosis (ORN), odontogenic infection, foreign body, and trauma were investigated. A separate analysis showed the number of MRONJ cases in two age groups (under 70 years; 70 years and over) and serum C-terminal peptide (s-CTX) values that were found.

Results

The results showed that the number of MRONJ cases was significantly larger in the older age group (p < 0.05). Regarding gender and sites of lesions, MRONJ was significantly frequent in the female and the mandible (p < 0.05). The R 2 values for the regression analysis for MRONJ (R 2 = 0.9234) and odontogenic etiology (R 2 = 0.0427) signified linear increase in the number of MRONJ cases, whereas bone lesions due to traditional odontogenic etiology stayed stationary.

Conclusion

The number of MRONJ has escalated, and most of the patients are elderly people. The current trend of inflammatory conditions of the jaw may have changed since the advent of MRONJ.

Clinical relevance

Long-term bisphosphonate therapy became a major risk factor for the osteomyelitis and osteonecrosis of the jaws. Thorough medical history, taking would be essential and communication with prescribing physicians should be emphasized during the dental treatment planning.

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Authors and Affiliations

  1. Department of Dentistry (Oral & Maxillofacial Surgery), International St. Mary’s Hospital, Catholic Kwandong University, Incheon, South Korea

    Sung Ok Hong

  2. Department of Oral & Maxillofacial Surgery, Graduate School, Kyung Hee University, Kyungheedaero 26, Seoul, 02447, South Korea

    Chae-Yoon Lee

  3. Department of Oral & Maxillofacial Surgery, Universitätsmedizin Mainz, Augustusplatz 2, Mainz, 55131, Germany

    Junho Jung & Christian Walter

  4. Department of Nuclear Medicine, School of Medicine, Kyung Hee University, Kyungheedaero 26, Seoul, 02447, South Korea

    Deog-Yoon Kim

  5. Department of Oral & Maxillofacial Surgery, Center for Refractory Jawbone Diseases, School of Dentistry, Kyung Hee University, Kyungheedaero 26, Seoul, 02447, South Korea

    Yong-Dae Kwon

Authors
  1. Sung Ok Hong
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  2. Chae-Yoon Lee
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Corresponding author

Correspondence to Yong-Dae Kwon.

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Conflict of interest

The authors declare that they have no conflict of interest.

Funding

This research was supported by a grant of the Korea Health Technology R&D project through the KHIDI, funded by the Ministry of Health and Welfare, Republic of Korea (HI14C1812).

Ethical approval

The study does not include any personal information of patients. This study protocol has been approved by Kyung Hee University Dental Hospital IRB (KHD IRB 1411-2).

Informed consent

The patients were informed of the scientific use of their clinical data.

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Hong, S.O., Lee, CY., Jung, J. et al. A retrospective study of osteomyelitis and osteonecrosis of the jaws and its etiologic implication of bisphosphonate in Asians. Clin Oral Invest 21, 1905–1911 (2017). https://doi.org/10.1007/s00784-016-1973-2

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  • DOI: https://doi.org/10.1007/s00784-016-1973-2

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