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Three-year results following regenerative periodontal surgery of advanced intrabony defects with enamel matrix derivative alone or combined with a synthetic bone graft

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Abstract

Objectives

This study aims to compare the clinical outcomes of a combination of enamel matrix derivatives (EMD) and a synthetic bone graft (biphasic calcium phosphate) with EMD alone in wide and deep one- and two-wall intrabony defects 36 months after treatment.

Material and methods

Thirty patients with chronic periodontitis and one wide (≥ 2 mm) and deep (≥ 4 mm) intrabony defect had been recruited in three centres in Germany. During surgery, defects were randomly assigned to EMD/synthetic bone graft (SBG) (test) or EMD (control). Assessments at baseline, after 6, 12 and 36 months, included bone sounding, relative clinical attachment levels, probing pocket depths and recessions.

Results

After 36 months, defects in both groups were significantly improved (p < 0.001) with regard to defect fill, attachment gain and probing pocket reduction. In the EMD/SBG group, a mean defect fill of 2.6 mm (±1.7) was measured, and in the EMD group, the defect fill was 2.3 mm (±1.5). A mean gain in clinical attachment of 4.1 mm (±3.6) and 3.8 mm (±2.2) was observed in the test and in the control group, respectively. There were no statistically significant differences in any of the investigated parameters between the two treatment modalities.

Conclusions

The clinical improvements of advanced intrabony defects obtained with both regenerative modalities could be maintained over a period of 3 years. The combination of EMD with SBG did not show any advantage compared to the use of EMD alone.

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Source of funding

The initial phase of this study (baseline to 12 months) was supported by the Institut Straumann AG, Basel, Switzerland. The 3-year follow-up was funded by the authors’ own institutions.

Conflict of interest

The authors declare that they have no competing interests.

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Author notes

    Authors and Affiliations

    1. Department of Periodontology, TU Dresden, Dresden, Germany

      Thomas Hoffmann & Elyan Al-Machot

    2. Department of Periodontology, University of Giessen, Giessen, Germany

      Jörg Meyle

    3. Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Welschnonnenstrasse 17, 53111, Bonn, Germany

      Pia-Merete Jervøe-Storm & Søren Jepsen

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    1. Thomas Hoffmann
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    2. Elyan Al-Machot
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    5. Søren Jepsen
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    Corresponding author

    Correspondence to Søren Jepsen.

    Additional information

    Thomas Hoffmann and Elyan Al-Machot contributed equally to this work.

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    Hoffmann, T., Al-Machot, E., Meyle, J. et al. Three-year results following regenerative periodontal surgery of advanced intrabony defects with enamel matrix derivative alone or combined with a synthetic bone graft. Clin Oral Invest 20, 357–364 (2016). https://doi.org/10.1007/s00784-015-1522-4

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