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Comparative study of DFDBA in combination with enamel matrix derivative versus DFDBA alone for treatment of periodontal intrabony defects at 12 months post-surgery

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Abstract

The aim of this randomized double-blind, clinical trial was to compare the use of enamel matrix derivative (EMD) and demineralised freeze-dried bone allografts (DFDBA) with DFDBA alone for the treatment of human periodontal intrabony defects at 12 months post-surgery. Fifty-six intrabony osseous defects in 56 periodontis patients were randomly assigned to the test group (DFDBA + EMD) or the control group (DFDBA) for periodontal treatment. Clinical and radiographic measurements were made at the baseline and after 12 months. Compared to baseline, the 12-month results indicated that both treatment modalities resulted in significant changes in all clinical parameters (gingival index, bleeding on probing, probing depth (PD), clinical attachment level (CAL), gingival recession; P < 0.05) and radiographic parameters (hard tissue fill (HTF) and bone depth reduction; P < 0.05). Furthermore, statistically significant differences were found in the test group compared to the control group in PD reduction (5.0 mm vs. 4.0 mm; P < 0.05), CAL gain (4.0 mm vs. 3.25 mm), and HTF (4.0 mm vs. 3.5 mm; P < 0.05). In the test group, 25% of sites gained >4 mm of CAL, while in the control group, 7.1% of sites gained >4 mm of CAL. Both treatments showed a good soft and hard periodontal tissue response. At 12 months post-surgery, the combined use of DFDBA and EMD seemed to produce a statistically significant improvement of PD reduction, CAL gain, and HTF.

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Notes

  1. MTF, Musculoskeletal Transplant Foundation, Edison, NJ.

  2. Emdogain, Straumann Biologics Division, Waltham, MA; previously, Biora, Inc., Malmo, Sweden

  3. UNC-15 periodontal probe, Hu-Friedy, Chicago, IL.

  4. Trophy Radiologie, 708 G, 70 kV, Vincennes, France.

  5. Kodak Ultraspeed DF58, Eastman Kodak, Rochester NY.

  6. Prefgel, Straumann Biologic Division

  7. MONOMYD MM-2620 Butterfly Italia, Cavenago B.za (MI), Italy, www.butterflyitalia.com

  8. CICLADOL Rottapharm SpA, Monza, Italy, www.rottapharm.it

  9. Corsodyl, GlaxoSmithKline

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Periodontology—Department of Clinical and Dental Sciences, Polytechnic University of the Marche, Via Tronto 10/a, Torrette di Ancona, Italy

    Simone Domenico Aspriello & Matteo Piemontese

  2. Medical Statistics—Department of Clinical Medicine and Applied Biotechnologies, Polytechnic University of the Marche, Ancona Torrette, Italy

    Luigi Ferrante

  3. Periodontology and Oral Pathology—Institute of Harmed Anatomy, Department of Neurosciences, Polytechnic University of the Marche, Ancona Torrette, Italy

    Corrado Rubini

Authors
  1. Simone Domenico Aspriello
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  2. Luigi Ferrante
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Correspondence to Matteo Piemontese.

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Aspriello, S.D., Ferrante, L., Rubini, C. et al. Comparative study of DFDBA in combination with enamel matrix derivative versus DFDBA alone for treatment of periodontal intrabony defects at 12 months post-surgery. Clin Oral Invest 15, 225–232 (2011). https://doi.org/10.1007/s00784-009-0369-y

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