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Pulse or hyaline ring granuloma. Review of the literature on etiopathogenesis of oral and extraoral lesions

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Abstract

Since the late 1950s, reports on an unusual giant-cell granulomatous lesion affecting the jaws, lungs, stomach and intestines have been published . Histopathologically, the lesions showed the presence of structureless hyaline rings with multinucleated giant cells. The aim of this review was to summarize the literature on the etiopathogenesis of the so-called oral and extraoral pulse or hyaline ring granuloma. Literature was searched using PubMed and Medline. In addition, hand search was performed. Search words were oral and extraoral hyaline ring granuloma, giant-cell hyaline angiopathy, pulse granuloma and chronic periostitis. Numerous terms for hyaline ring granuloma have been introduced over time (1971–2008). One hundred seventy-three cases of oral hyaline ring granuloma have been retrieved from the literature. In the mandible, 72.3% occurred . Two theories for etiopathogenesis have been proposed: (1) the origin of the hyaline rings is due to a foreign material (pulse and legumes) having penetrated the oral mucosa or gastrointestinal tract and lungs (exogenous theory) and (2) the rings are due to hyaline degenerative changes in walls of blood vessels (endogenous theory). Experimental production of oral and extraoral hyaline ring granulomas is consistent with the exogenous origin. Particles or remains of leguminous cells having been implanted or aspirated into human tissues whether located to the oral cavity or throughout the entire digestive tract and respiratory system are thought to be causative. Pulse or hyaline ring granulomas are rare but are well-defined oral and extraoral lesions due to implantation of the cellulose moiety of plant foods in contrast to the starch components.

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Acknowledgement

We are grateful to Dr. R. Wolf and Dr. U. Bosse, Osnabrück, Germany, for allowing us to publish the present case. We would also like to thank Prof. Dr. H. Ostertag, Pathologisches Institut Klinikum Hannover im Krankenhaus Nordstadt, Hannover, Germany, who kindly placed microscopical slides from the previously discussed case report at our disposal.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Vejlesoeparken, 2840, Holte, Denmark

    Hans Peter Philipsen

  2. Department of Oral Surgery and Stomatology, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland

    Peter A. Reichart

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  1. Hans Peter Philipsen
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  2. Peter A. Reichart
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Correspondence to Peter A. Reichart.

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Philipsen, H.P., Reichart, P.A. Pulse or hyaline ring granuloma. Review of the literature on etiopathogenesis of oral and extraoral lesions. Clin Oral Invest 14, 121–128 (2010). https://doi.org/10.1007/s00784-009-0322-0

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  • DOI: https://doi.org/10.1007/s00784-009-0322-0

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