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Somatic stem cells for regenerative dentistry

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Abstract

Complex human tissues harbour stem cells and/or precursor cells, which are responsible for tissue development or repair. Recently, dental tissues such as periodontal ligament (PDL), dental papilla or dental follicle have been identified as easily accessible sources of undifferentiated cells. The dental stem cell biology might provide meaningful insights into the development of dental tissues and cellular differentiation processes. Dental stem cells could also be feasible tools for dental tissue engineering. Constructing complex structures like a periodontium, which provides the functional connection between a tooth or an implant and the surrounding jaw, could effectively improve modern dentistry. Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This review gives a short overview of stem cells of dental origin.

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Authors and Affiliations

  1. Institute of Human Genetics, University of Regensburg, Regensburg, Germany

    Christian Morsczeck & Florian Völlner

  2. Department of Conservative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany

    Gottfried Schmalz & Kerstin Galler

  3. Department of Oral and Maxillofacial Surgery, University of Regensburg, Regensburg, Germany

    Torsten Eugen Reichert & Oliver Driemel

  4. Institut für Humangenetik, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany

    Christian Morsczeck

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  1. Christian Morsczeck
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  2. Gottfried Schmalz
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  4. Florian Völlner
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Correspondence to Christian Morsczeck.

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Morsczeck, C., Schmalz, G., Reichert, T.E. et al. Somatic stem cells for regenerative dentistry. Clin Oral Invest 12, 113–118 (2008). https://doi.org/10.1007/s00784-007-0170-8

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  • DOI: https://doi.org/10.1007/s00784-007-0170-8

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