Abstract.
Our study focuses on the antineoplasmic action of hyperthermia. In this study, use of a heat-generating cement was exploited for the management of pathological and impending fractures in malignancies. The cement contains magnetic powder in ceramic particles and generates well-regulated heat when a magnetic field is applied externally. Eighteen rabbits were inoculated with blocks of VX2 tumor into one of their tibia. One week after the procedure, 9 rabbits were exposed to a magnetic field (HT group) while the remaining 9 rabbits were not (non-HT group). In rabbits killed between 20 and 42 days after the VX2 inoculation, the circumference of the operated leg was 7.9 ± 0.3 cm and 10.2 ± 1.0 cm (mean ± SE) in HT and non-HT groups, respectively (P < 0.05). Histological findings revealed the regressive change in tumor tissue of the HT group. By radiographs, pathological fractures and cortical bone destruction were seen in 5 and 8 rabbits in the non-HT group, respectively, but in the HT group these effects were absent in all the rabbits except 1 in which a definite diagnosis has not been made. Our findings demonstrate that controlled hyperthermia therapy using a newly developed bone cement suppresses tumor growth and prevents local bone destruction caused by VX2 tumors.
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Received: January 9, 2001 / Accepted: January 7, 2002
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Kusaka, M., Takegami, K., Sudo, A. et al. Effect of hyperthermia by magnetite cement on tumor-induced bone destruction. J Orthop Sci 7, 354–357 (2002). https://doi.org/10.1007/s007760200059
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DOI: https://doi.org/10.1007/s007760200059