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Atypical ulnar fracture associated with long-term bisphosphonate use

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Journal of Orthopaedic Science

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References

  1. Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CY. Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab. 2005;90:1294–301.

    Article  CAS  PubMed  Google Scholar 

  2. Visekruna M, Wilson D, McKierman FE. Severely suppressed bone turnover and atypical skeletal fragility. J Clin Endocrinol Metab. 2008;93:2948–52.

    Article  CAS  PubMed  Google Scholar 

  3. Stathopoulos KD, Kosmidis C, Lyritis GP. Atypical fractures of the femur and ulna and complications of fracture healing in a 76-year-old woman with Sjögren’s syndrome. J Musculoskelet Neuronal Interact. 2011;11:208–11.

    CAS  PubMed  Google Scholar 

  4. Tang ZH, Kumar VP. Alendronate-associated ulnar and tibial fractures: a case report. J Orthop Surg (Hong Kong). 2011;19:37022.

    Google Scholar 

  5. Bjørgul K, Reigstad A. Atypical fracture of the ulna associated with alendronate use. Acta Orthop. 2011;82:761–3.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Ang BF, Koh JS, Ng AC, Howe TS. Bilateral ulna fractures associated with bisphosphonate therapy. Osteoporos Int. 2013;24:1523–5.

    Article  CAS  PubMed  Google Scholar 

  7. Recker RR, Kimmel DB, Parfitt AM, Davies KM, Keshawarz N, Hinders S. Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females. J Bone Miner Res. 1988;3:133–44.

    Article  CAS  PubMed  Google Scholar 

  8. Black DM, Kelly MP, Genant HK, Palermo L, Eastell R, Bucci-Rechweg C, Cauley J, Leung PC, Boonen S, Santora A, de Papp A, Bauer DC, Fracture Intervention Trial Steering Committee, HORIZON Pivotal Fracture Trial Steering Committee. Bisphosphonate and fractures of the subtrochanteric or diaphyseal femur. N Engl J Med. 2010;362:1761–71.

    Article  CAS  PubMed  Google Scholar 

  9. Park-Wyllie LY, Mandani MM, Juurlink DN, Hawker GA, Gunraj N, Austin PC, Whelan DB, Weiler PJ, Laupacis A. Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women. JAMA. 2011;305:783–9.

    Article  CAS  PubMed  Google Scholar 

  10. Kwek EB, Goh SK, Koh JS, Png MA, Howe TS. An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Inj Int J Care Inj. 2008;39:224–31.

    Article  Google Scholar 

  11. Giusti A, Hamdy NA, Papapoulos SE. Atypical fractures of the femur and bisphosphonate therapy. Bone. 2010;47:169–80.

    Article  CAS  PubMed  Google Scholar 

  12. Tjhia CK, Odvina CV, Rao DS, Stover SM, Wang X, Fyhrie DP. Mechanical property and tissue mineral density differences among severely suppressed bone turnover (SSBT) patients, osteoporotic patients, and normal subjects. Bone. 2011;49:1279–89.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Aspenberg P, Schilcher J, Fahlgren A. Histology of an undisplaced femoral fatigue fracture in association with bisphosphonate treatment: frozen bone with remodeling at the crack. Acta Orthop. 2010;81:460–2.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Somford MP, Draijer FW, Thomassen BJW, Chavassieux PM, Boivin G, Papapoulos SE. Bilateral fractures of the femur diaphysis in a patient with rheumatoid arthritis on long-term treatment with alendronate: clues to the mechanism of increased bone fragility. J Bone Miner Res. 2009;24:1736–40.

    Article  PubMed  Google Scholar 

  15. Schilcher J, Michaelsson K, Aspenberg P. Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med. 2011;364:1728–37.

    Article  CAS  PubMed  Google Scholar 

  16. Carvalho NNC, Voss LA, Almeida OP, Salgado CL, Badeira F. Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide. J Clin Endocrinol Metab. 2011;96:2675–80.

    Article  CAS  PubMed  Google Scholar 

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There are no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Ryusuke Osada, Mineyuki Zukawa & Tomoatsu Kimura

Authors
  1. Ryusuke Osada
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  2. Mineyuki Zukawa
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  3. Tomoatsu Kimura
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Correspondence to Ryusuke Osada.

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Osada, R., Zukawa, M. & Kimura, T. Atypical ulnar fracture associated with long-term bisphosphonate use. J Orthop Sci 20, 1132–1135 (2015). https://doi.org/10.1007/s00776-014-0589-0

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  • DOI: https://doi.org/10.1007/s00776-014-0589-0

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