Abstract
Background
This study investigated the etiology, personal risk factors, and quality of life related to Dupuytren’s disease among residents of a mountain village in Japan.
Methods
Medical examinations were conducted of 401 adult residents (163 men, 238 women; average age of 66.7 years, range 40–92) of a mountain village in Japan. All had completed a self-administered questionnaire including items for gender, weight, height, dominant hand, occupation, history of diabetes mellitus, and frequency of smoking tobacco and drinking alcohol, in addition to EuroQol-5-Dimensions-3-level Japanese version. Blood samples were collected and assessed for biochemical markers related to Dupuytren’s disease. The Dupuytren’s disease diagnosis was based on clinical signs. Meyerding’s classification was used to ascertain the disease severity. After examining background data and physical examination data related to Dupuytren’s disease, we evaluated the association of Dupuytren’s disease with those factors using univariate and logistic regression analysis.
Results
Dupuytren’s disease was diagnosed in 28 subjects (7.0 %). Univariate analysis revealed associations of age, male gender, occupation, history of diabetes mellitus, and alcohol intake with Dupuytren’s disease. Logistic regression analysis after adjustment for age revealed a significant association between Dupuytren’s disease and male gender, occupation, and history of alcohol intake. No significant difference was found between Dupuytren’s disease patients and participants without this disease in the scoring and visual analog scale of EuroQol. No relation was found in scoring, the visual analog scale of EuroQol, or grading of Meyerding’s classification in participants with Dupuytren’s disease.
Conclusion
This cross-sectional study revealed Dupuytren’s disease in 7.0 % of 401 subjects among the general population of a mountain village in Japan. The prevalence is higher with age and is apparently associated with male gender, occupation and alcohol intake. Risk factors associated with Dupuytren’s disease were identified as age, male gender, occupation, and alcohol consumption habits.
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References
Gudmundsson KG, Arngrímsson R, Sigfússon N, Björnsson A, Jónsson T. Epidemiology of Dupuytren’s disease: clinical serological, and social assessment. The Reykjavik Study. J Clin Epidemiol. 2000;53:291–6.
Degreef I, De Smet L. A high prevalence of Dupuytren’s disease in Flanders. Acta Orthop Belg. 2010;76:316–20.
Burge P. Genetics of Dupuytren’s disease. Hand Clin. 1999;15:63–71.
Arafa M, Noble J, Royle SG, Trail IA, Allen J. Dupuytren’s and epilepsy revisited. J Hand Surg Br. 1992;17:221–4.
Godtfredsen NS, Lucht H, Prescott E, Sørensen TIA, Grønbæk M. A prospective study linked both alcohol and tobacco to Dupuytren’s disease. J Clin Epidemiol. 2004;57:858–63.
Descatha A, Jauffret P, Chastang JF, Roquelaure Y, Leclerc A. Should we consider Dupuytren’s contracture as work-related? A review and meta-analysis of an old debate. BMC Musculoskelet Disord. 2011;16:96.
Sandersson PL, Morris MA, Stanley JK, Fahmy NR. Lipids and Dupuytren’s disease. J Bone Joint Surg. 1992;74:923–7.
Egawa T, Horiki A, Senrui H. Dupuytren’s contracure in Japan. In: McFarlane RM, editor. Dupuytren’s disease. Edinburgh: Churchill Livingstone; 1985. p. 100–3.
Group E. EuroQol—a new facility for the measurement of health-related quality of life. Health policy. 1990;16:199–208.
Soer R, Reneman MF, Speijer BL, Coppes MH, Vroomen PC. Clinimetric properties of the EuroQol-5D in patients with chronic low back pain. Spine J. 2012;12:1035–9.
Tsuchiya A, Ikeda S, Ikegami N, Nishimura S, Sakai I, Fukuda T, Hamashima C, Hisashige A, Tamura M. Estimating an EQ-5D population value set: the case of Japan. Health Econ. 2002;11:341–53.
Meyrding HW. Dupuytren’s contracture. Arch Surg. 1936;32:320–3.
McFarlane RM. On the origin and spread of Dupuytren’s disease. J Hand Surg Am. 2002;27:385–90.
Pagnotta A, Specchia N, Greco F. Androgen receptors in patients with Dupuytren’s contracture. J Orthop Res. 2002;20:163–8.
Descatha A, Bodin J, Ha C, Goubault P, Lebreton M, Chastang JF, Imbernon E, Leclerc A, Goldberg M, Roquelaure Y. Heavy manual work, exposure to vibration and Dupuytren’s disease? Results of a surveillance program for musculoskeletal disorders. Occup Environ Med. 2012;69:296–9.
Geoghegan JM, Forbes J, Clark DI, Smith C, Hubbard R. Dupuytren’s disease risk factors. J Hand Surg Br. 2004;29:423–6.
Shaw RB Jr, Chong AK, Zhang A, Hentz VR, Chang J. Dupuytren’s disease: history, diagnosis, and treatment. Plast Reconst Surg. 2007;120:44e–54e.
Bertrand J, Thomas J, Metman E. Maladie de Dupuytren et erythrose palmaire au cours des cirrhosis ethyliques. Sem Hop. 1977;53:407–12 (in French).
Noble J, Arafa M, Royle SG, McGeorge G, Crank S. The association between alcohol, hepatic pathology and Dupuytren’s disease. J Hand Surg. 1992;17-B:71–4.
Pan D, Watson HK, Swigart C, Thomson JG, Honing SC, Narayan D. Microarray gene analysis and expression profiles of Dupuytren’s contracture. Ann Plast Surg. 2003;50:618–22.
Trybus M, Bednarek M, Lorkowski J, Teul I. Psychologic aspects of Dupuytren’s disease: a new scale of subjective well-being of patients. Ann Acad Med Stetin. 2011;57(1):31–7 (discussion 37).
Deyo RA, Diehr P, Patrick DL. Reproducibility and responsiveness of health status measures. Statistics and strategies for evaluation. Control Clin Trials 1991;12:142–58S.
Acknowledgments
The authors thank the participants and the medical staff and public health nurses of the regional health center for their assistance and support in this study.
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The authors declare that they have no conflict of interest.
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Tajika, T., Kobayashi, T., Kaneko, T. et al. Epidemiological study for personal risk factors and quality of life related to Dupuytren’s disease in a mountain village of Japan. J Orthop Sci 19, 64–70 (2014). https://doi.org/10.1007/s00776-013-0478-y
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DOI: https://doi.org/10.1007/s00776-013-0478-y