Abstract
Background
A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA. Such an association has not been previously described among the Mexican mestizo population. The aim of this study was to analyze the association of the ASPN gene D-repeat polymorphism in a Mexican mestizo population with primary knee OA as well as in healthy controls.
Materials and methods
A case–control study was conducted on a Mexican mestizo population of northern Mexico. The repeat polymorphism was genotyped in 440 subjects (218 cases and 222 healthy controls). Primary knee OA was diagnosed according to American College of Rheumatology and Kellgren-Lawrence criteria, and allelic association was examined adjusting for other risk variables.
Results
After adjusting for some covariates, menopause and the D16 allele showed a trend toward being risk factors for knee OA in a Mexican mestizo population. Also, the D12 allele could be considered as a protective factor.
Conclusions
These findings suggest that polymorphisms within the ASPN gene could influence knee OA susceptibility, but these associations must be confirmed by independent studies in larger samples and different ethnic groups to support the role of the D-repeat polymorphism in the ASPN gene as risk or protection factors for knee OA in a Mexican population.
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Acknowledgments
We would like to thank Gabriela Salinas Medina from the Instituto de Ciencia y Medicina Genómica Torreón, Mexico, for her technical support; Ignacio Rego Pérez from Instituto de Investigación Biomédica (INIBIC) A Coruña, Spain, for his statistical analysis support; Pablo Ruiz Flores, and María Elena Cortéz and Francisco Carlos Lopez Marquez from the Centro de Investigación Biomédica Torreón, Mexico, for their review of the manuscript. We would also like to thank Juanita Oropeza, Rubén Dario Galvan, Claudia Hernandez Vallejo, René Rodriguez and Eduardo Serna Zetina from Facultad de Medicina, Torreón, Mexico, for their invaluable logistical and administrative support. This study was funded by the Facultad de Medicina Torreón, Universidad Autónoma de Coahuila, Mexico, and Instituto de Ciencia y Medicina Genómica, Torreón, Mexico. The study sponsors had no involvement in the study design, collection, analysis and interpretation of data or the decision to submit this manuscript for publication.
Conflict of interest
The authors declare that they have no competing interests that could potentially and inappropriately influence their work and conclusions.
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Arellano, R.D., Hernández, F., García-Sepúlveda, C.A. et al. The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: a case–control study. J Orthop Sci 18, 826–831 (2013). https://doi.org/10.1007/s00776-013-0414-1
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DOI: https://doi.org/10.1007/s00776-013-0414-1