Skip to main content
SpringerLink
Log in

Extraskeletal osteosarcoma in Japan: multiinstitutional study of 20 patients from the Japanese Musculoskeletal Oncology Group

  • Original article
  • Published:
Journal of Orthopaedic Science

Abstract

Background

The clinical features of extraskeletal osteosarcoma are not well known. Unlike osteosarcoma of the bone, the efficacy of chemotherapy for extraskeletal osteosarcoma has not been established yet.

Methods

A multiinstitutional study of extraskeletal osteosarcoma was conducted.

Results

A total of 20 patients were enrolled in the study from the Japanese Musculoskeletal Oncology Group institutions. Their ages ranged from 15 to 88 years (mean 50 years). Six lesions were located in the thigh, four in the chest, four in the buttocks, three in the upper arm, and others. UICC surgical stages were II in 5 patients, III in 13, and IV in 2. Surgical resection was performed in 19 patients, and the consequent surgical margin was wide in 15 patients, marginal in 3, and intralesional in 1. The overall 5-year survival rate was 66%. Three patients demonstrated tumor recurrence postoperatively, and the 5-year local control survival rate was 75%. Altogether, 15 patients received chemotherapy, of whom 11 had evaluable responses as follows: complete response in none, partial response in 5 patients, and no change or progressive disease in 6 patients, with a response rate of 45%.

Conclusions

Among the patients with extraskeletal osteosarcoma, both the 5-year survival rate and the chemotherapy response rate tended to improve in this study in comparison to the findings published in previous reports. As a result, we believe that treatment regimens that include systemic chemotherapy may be able to improve the prognosis in patients with extraskeletal osteosarcoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. AE Rosenberg S Heim (2002) Extraskeletal osteosarcoma CD Fletcher KK Unni F Mertens (Eds) Pathology and genetics of tumours of soft tissue and bone IARC Lyon 182–83

    Google Scholar 

  2. M Lidang Jensen B Schumacher O Myhre Jensen O Steen Nielsen J Keller (1998) ArticleTitleExtraskeletal osteosarcomas: a clinicopathologic study of 25 cases Am J Surg Pathol 22 588–94 10.1097/00000478-199805000-00010 Occurrence Handle10.1097/00000478-199805000-00010 Occurrence Handle1:STN:280:DyaK1c3lt1CjsQ%3D%3D Occurrence Handle9591729

    Article  CAS  PubMed  Google Scholar 

  3. PP Sordillo SI Hajdu GB Magill RB Golbey (1983) ArticleTitleExtraosseous osteogenic sarcoma: a review of 48 patients Cancer 51 727–34 10.1002/1097-0142(19830215)51:4<727::AID-CNCR2820510429>3.0.CO;2-I Occurrence Handle10.1002/1097-0142(19830215)51:4<727::AID-CNCR2820510429>3.0.CO;2-I Occurrence Handle1:STN:280:DyaL3s7gt1Oktw%3D%3D Occurrence Handle6571801

    Article  CAS  PubMed  Google Scholar 

  4. CJ Allan EH Soule (1971) ArticleTitleOsteogenic sarcoma of the somatic soft tissues: clinicopathologic study of 26 cases and review of literature Cancer 27 1121–33 10.1002/1097-0142(197105)27:5<1121::AID-CNCR2820270519>3.0.CO;2-3 Occurrence Handle10.1002/1097-0142(197105)27:5<1121::AID-CNCR2820270519>3.0.CO;2-3 Occurrence Handle1:STN:280:DyaE3M3ht1ajuw%3D%3D Occurrence Handle5281245

    Article  CAS  PubMed  Google Scholar 

  5. JS Lee JF Fetsch DA Wasdhal BP Lee DJ Pritchard AG Nascimento (1995) ArticleTitleA review of 40 patients with extraskeletal osteosarcoma Cancer 76 2253–59 10.1002/1097-0142(19951201)76:11<2253::AID-CNCR2820761112>3.0.CO;2-8 Occurrence Handle10.1002/1097-0142(19951201)76:11<2253::AID-CNCR2820761112>3.0.CO;2-8 Occurrence Handle1:STN:280:DyaK283itlakug%3D%3D Occurrence Handle8635029

    Article  CAS  PubMed  Google Scholar 

  6. BL Bane HL Evans JY Ro CH Carrasco DJ Grignon RS Benjamin et al. (1990) ArticleTitleExtraskeletal osteosarcoma: a clinicopatholigic review of 26 cases Cancer 65 2762–70 10.1002/1097-0142(19900615)65:12<2762::AID-CNCR2820651226>3.0.CO;2-K Occurrence Handle10.1002/1097-0142(19900615)65:12<2762::AID-CNCR2820651226>3.0.CO;2-K Occurrence Handle1:STN:280:DyaK3c3lsVGmtQ%3D%3D Occurrence Handle2160317

    Article  CAS  PubMed  Google Scholar 

  7. HJ Mankin FJ Hornicek AE Rosenberg DC Harmon MC Gebhardt (2004) ArticleTitleSurvival data for 648 patients with osteosarcoma treated at one institution Clin Orthop 429 286–91 10.1097/01.blo.0000145991.65770.e6 Occurrence Handle10.1097/01.blo.0000145991.65770.e6 Occurrence Handle15577500

    Article  PubMed  Google Scholar 

  8. EB Chung FM Enzinger (1987) ArticleTitleExtraskeletal osteosarcoma Cancer 60 1132–42 10.1002/1097-0142(19870901)60:5<1132::AID-CNCR2820600536>3.0.CO;2-L Occurrence Handle10.1002/1097-0142(19870901)60:5<1132::AID-CNCR2820600536>3.0.CO;2-L Occurrence Handle1:STN:280:DyaL2s3ntlWisQ%3D%3D Occurrence Handle3475157

    Article  CAS  PubMed  Google Scholar 

  9. U Rao A Cheng MS Didolkar (1978) ArticleTitleExtraosseous osteogenic sarcoma: clinicopathological study of eight cases and review literature Cancer 41 1488–96 10.1002/1097-0142(197804)41:4<1488::AID-CNCR2820410437>3.0.CO;2-A Occurrence Handle10.1002/1097-0142(197804)41:4<1488::AID-CNCR2820410437>3.0.CO;2-A Occurrence Handle1:STN:280:DyaE1c7ks1aktg%3D%3D Occurrence Handle346199

    Article  CAS  PubMed  Google Scholar 

  10. SA Ahmad SR Patel MT Ballo TP Baker AW Yasko X Wang et al. (2002) ArticleTitleExtraosseous osteosarcoma: response to treatment and long-term outcome J Clin Oncol 20 521–7 10.1200/JCO.20.2.521 Occurrence Handle10.1200/JCO.20.2.521 Occurrence Handle11786582

    Article  PubMed  Google Scholar 

  11. FM Enzinger SW Weiss (2001) In: Malignant fibrous histiocytoma: soft tissue tumors Mosby St. Louis 539–69

    Google Scholar 

  12. DJ Pritchard HM Reiman RE Turcotte DM Ilstrup (1993) ArticleTitleMalignant fibrous histiocytoma of the soft tissues of the trunk and extremities Clin Orthop 289 58–65 Occurrence Handle8386072

    PubMed  Google Scholar 

  13. N Kawaguchi AR Ahmed S Matsumoto J Manabe Y Matsushita (2004) ArticleTitleThe concept of curative margin in surgery for bone and soft tissue sarcoma Clin Orthop 419 165–72 10.1097/00003086-200402000-00027 Occurrence Handle10.1097/00003086-200402000-00027 Occurrence Handle15021149

    Article  PubMed  Google Scholar 

  14. SW Weiss FM Enzinger (1978) ArticleTitleMalignant fibrous histiocytoma: an analysis of 200 cases Cancer 41 2250–66 10.1002/1097-0142(197806)41:6<2250::AID-CNCR2820410626>3.0.CO;2-W Occurrence Handle10.1002/1097-0142(197806)41:6<2250::AID-CNCR2820410626>3.0.CO;2-W Occurrence Handle1:STN:280:DyaE1c7ovVKntA%3D%3D Occurrence Handle207408

    Article  CAS  PubMed  Google Scholar 

  15. K Shinjo (1994) ArticleTitleAnalysis of prognostic factors and chemotherapy of malignant fibrous histiocytoma of soft tissue: a preliminary report Jpn J Clin Oncol 24 154–9 Occurrence Handle1:STN:280:DyaK2c3ns1eitQ%3D%3D Occurrence Handle8007425

    CAS  PubMed  Google Scholar 

  16. M Van Glabbeke AT van Oosterom JW Oosterhuis H Mouridsen D Crowther R Somers et al. (1999) ArticleTitlePrognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2185 patients treated with anthracyclin-containing first-line regimens — a European organization for research and treatment of cancer soft tissue and bone sarcoma group study J Clin Oncol 17 150–7 Occurrence Handle1:CAS:528:DyaK1MXltVyrsg%3D%3D Occurrence Handle10458228

    CAS  PubMed  Google Scholar 

  17. SY Goldstein-Jackson G Gosheger G Delling WE Berdel GU Exner G Jundt et al. (2005) ArticleTitleExtraskeletal osteosarcoma has a favourable prognosis when treated like conventional osteosarcoma J Cancer Res Clin Oncol 131 520–6 10.1007/s00432-005-0687-7 Occurrence Handle10.1007/s00432-005-0687-7 Occurrence Handle15918046

    Article  PubMed  Google Scholar 

  18. JC Salo JJ Lewis JM Woodruff DH Leung MF Brennan (1999) ArticleTitleMalignant fibrous histiocytoma of the extremity Cancer 85 1765–72 10.1002/(SICI)1097-0142(19990415)85:8<1765::AID-CNCR17>3.0.CO;2-K Occurrence Handle10.1002/(SICI)1097-0142(19990415)85:8<1765::AID-CNCR17>3.0.CO;2-K Occurrence Handle1:STN:280:DyaK1M3jvVSrsA%3D%3D Occurrence Handle10223571

    Article  CAS  PubMed  Google Scholar 

  19. V Le Doussal JM Coindre A Leroux K Hacene P Terrier NB Bui et al. (1996) ArticleTitlePrognostic factors for patients with localized primary malignant fibrous histiocytoma Cancer 77 1823–30 10.1002/(SICI)1097-0142(19960501)77:9<1823::AID-CNCR10>3.0.CO;2-1 Occurrence Handle10.1002/(SICI)1097-0142(19960501)77:9<1823::AID-CNCR10>3.0.CO;2-1 Occurrence Handle1:STN:280:DyaK283gvVGkug%3D%3D Occurrence Handle8646680

    Article  CAS  PubMed  Google Scholar 

  20. Sarcoma meta-analysis collaboration: adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Lancet 1997;350:1647–1654

  21. FC Eilber G Rosen J Eckardt C Forscher SD Nelson M Selch et al. (2001) ArticleTitleTreatment-induced pathologic necrosis: a predictor of local recurrence and survival in patients receiving neoadjuvant therapy for high-grade extremity soft tissue sarcomas J Clin Oncol 19 3203–9 Occurrence Handle1:STN:280:DC%2BD3Mzns1Oluw%3D%3D Occurrence Handle11432887

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Juntendo University School of Medicine, 1-1 Hongo 2-chome, Bunkyo-ku, Tokyo, 113-8421, Japan

    Tomoaki Torigoe, Atsuhiko Terakado & Hisashi Kurosawa

  2. Department of Musculoskeletal Oncology, Tochigi Cancer Center, Utsunomiya, Japan

    Yasuo Yazawa

  3. Department of Orthopaedic Surgery, Shizuoka Cancer Center, Suntogun, Japan

    Tatsuya Takagi

Authors
  1. Tomoaki Torigoe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasuo Yazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tatsuya Takagi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Atsuhiko Terakado
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hisashi Kurosawa
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Torigoe, T., Yazawa, Y., Takagi, T. et al. Extraskeletal osteosarcoma in Japan: multiinstitutional study of 20 patients from the Japanese Musculoskeletal Oncology Group. J Orthop Sci 12, 424–429 (2007). https://doi.org/10.1007/s00776-007-1164-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00776-007-1164-8

Keywords

Search

Navigation