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Serum interleukin-6 response after spinal surgery: estimation of surgical magnitude

  • Original article
  • Published:
Journal of Orthopaedic Science

An Erratum to this article was published on 01 July 2007

Abstract

Background

Serum interleukin-6 (IL-6) has been used for quantitative estimation of the surgical magnitude of major cardiac and thoracoabdominal surgery, but there have been few studies assessing IL-6 as a marker of surgical magnitude of spinal surgery.

Methods

We investigated the changes in IL-6 response in comparison to other parameters of surgical magnitude and spinal surgery procedures. The study included 40 patients electively undergoing spinal surgery. The patients were divided into four groups: lumbar laminectomy with posterolateral fusion (PLF), lumbar laminotomy, lumbar open discectomy, and cervical laminoplasty. Serum IL-6, C-reactive protein (CRP), creatine kinase (CK), and the white blood cell (WBC) count were determined in venous blood before surgery, at the end of surgery, and 6 h and the first, third, and seventh days after surgery.

Results

Serum IL-6 peaked on the first day and returned to a normal value by the seventh day. The peak IL-6 concentrations on the first day after surgery significantly correlated with CRP, CK, duration of surgery, and estimated blood loss. Regarding lumbar surgeries, the peak IL-6 for laminectomy/PLF was significantly higher than that for laminotomy/open discectomy or for cervical laminoplasty.

Conclusions

Serum IL-6 on the first day varied depending on the surgical procedure used. Therefore, it might be a quantitative marker of surgical magnitude following spinal surgery.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan

    Satoru Demura, Norio Kawahara & Katsuro Tomita

  2. Department of Orthopedic Surgery, Saitama Medical School, Saitama, Japan

    Satoru Demura, Keisuke Takahashi & Yasuyuki Watanabe

Authors
  1. Satoru Demura
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  2. Keisuke Takahashi
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  3. Norio Kawahara
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  4. Yasuyuki Watanabe
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  5. Katsuro Tomita
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Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s00776-007-1158-6.

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Demura, S., Takahashi, K., Kawahara, N. et al. Serum interleukin-6 response after spinal surgery: estimation of surgical magnitude. J Orthop Sci 11, 241–247 (2006). https://doi.org/10.1007/s00776-006-1002-4

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  • DOI: https://doi.org/10.1007/s00776-006-1002-4

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