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A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis

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Abstract

The organometallic glutathione S-transferase inhibitor ruthenium(II) (ethacrynic acid-η6-benzylamide)(1,3,5-triaza-7-phosphaadamantane) dichloride, termed ethaRAPTA, has been demonstrated to induce apoptosis in the cisplatin-resistant MCF-7 breast cancer cell line. Probing the molecular basis of this activity suggests that the complex triggers multiple pathways toward apoptosis, including those involving endonuclease G, caspases, and c-Jun N-terminal kinase, which could provide a therapy for multi-drug-resistant tumors. Furthermore, the induction of heat shock protein 70 expression enhances selectivity of the complex for tumor cells, reducing the general toxicity.

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Acknowledgments

The authors express their sincere gratitude to the Department of Science and Technology, India. The Indo Swiss Bilateral Research Initiative (EPFL) is also gratefully acknowledged for funding this research.

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Authors and Affiliations

  1. Department of Environmental Science, University of Kalyani, Kalyani, 741235, India

    Soumya Chatterjee

  2. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland

    Ilaria Biondi & Paul J. Dyson

  3. Immunology Laboratory, Department of Zoology, University of Calcutta, Calcutta, 700019, India

    Soumya Chatterjee & Arindam Bhattacharyya

Authors
  1. Soumya Chatterjee
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  2. Ilaria Biondi
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  3. Paul J. Dyson
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  4. Arindam Bhattacharyya
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Corresponding author

Correspondence to Arindam Bhattacharyya.

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Chatterjee, S., Biondi, I., Dyson, P.J. et al. A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis. J Biol Inorg Chem 16, 715–724 (2011). https://doi.org/10.1007/s00775-011-0772-0

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