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Proton thrusters: overview of the structural and functional features of soluble tetrahaem cytochromes c 3

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Abstract

Tetrahaem cytochromes c 3 from sulfate-reducing bacteria have revealed exquisite complexity in their ligand binding properties and they couple the cooperative binding of two electrons with the binding of protons. In this review, the molecular mechanisms for these cooperative effects are described, and the functional consequences of these cooperativities are discussed in the context of the general mechanisms of biological energy transduction and the specific physiological metabolism of Desulfovibrio.

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Acknowledgements

The author is grateful to António Xavier, who passed away last May, for coaching, numerous suggestions, and many helpful, albeit lively discussions over many years. The author would like to thank the anonymous referees and the editor for numerous comments and suggestions that greatly contributed to improve the manuscript. The many discussions with and critical reading of the manuscript by Teresa Catarino and Carlos A. Salgueiro are gratefully acknowledged. Research in the author’s group is currently supported by Fundação para a Ciência e a Tecnologia grants POCI/BIO/58652, POCI/QUI/55690 and POCI/BIA-PRO/58722 cofunded by the FEDER programme.

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    Ricardo O. Louro

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Louro, R.O. Proton thrusters: overview of the structural and functional features of soluble tetrahaem cytochromes c 3 . J Biol Inorg Chem 12, 1–10 (2007). https://doi.org/10.1007/s00775-006-0165-y

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