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The oxo/peroxo debate: a nonheme iron perspective

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Abstract

The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.

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Acknowledgements

The work on nonheme iron enzymes and synthetic models thereof carried out in the Que laboratory has been generously supported by the National Institutes of Health (GM-33162 and GM-38767).

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  1. Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN , 55455, USA

    Lawrence Que Jr.

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  1. Lawrence Que Jr.
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Que, L. The oxo/peroxo debate: a nonheme iron perspective. J Biol Inorg Chem 9, 684–690 (2004). https://doi.org/10.1007/s00775-004-0574-8

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  • DOI: https://doi.org/10.1007/s00775-004-0574-8

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