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Relationship between autonomic nervous system activity and bone mineral density in non-medicated perimenopausal women

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Abstract

The autonomic nervous system (ANS) has attracted attention as a regulator of bone remodeling and the effects of beta-blockers on the prevention of osteoporosis have been studied. However, results are as yet inconclusive and the physiological role of the ANS in bone metabolism has not been clarified. Thus, we investigated the relationship between bone mineral density (BMD) and ANS activity in non-medicated perimenopausal women. ANS activity was evaluated by power spectral analysis of heart rate variability, and overall ANS activity and the balance between sympathetic and parasympathetic nervous activities (SNS and PNS) were quantified. Pre- and postmenopausal subjects were divided into higher or lower overall ANS activity groups, and were also divided into SNS- and PNS-dominant groups. BMD (percentage of young adult mean) was significantly higher in the higher overall ANS group than in the lower group (112.2 ± 16.2 % vs 99.7 ± 14.8 %, p < 0.05) of premenopausal subjects, but not in postmenopausal subjects (91.5 ± 15.9 % vs 91.0 ± 14.9 %). BMD was significantly higher in the SNS-dominant group than in the PNS-dominant group (94.1 ± 16.3 % vs 88.4 ± 18.8 %, p < 0.05) of postmenopausal subjects, but not in the premenopausal subjects (103.5 ± 18.4 % vs. 107.2 ± 14.6 %). Our study revealed that ANS influences bone metabolism under physiological conditions. Thus, it appears to be worthwhile to introduce ANS activity evaluation into the management of bone health in perimenopausal women.

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References

  1. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100:197–207

    Article  CAS  PubMed  Google Scholar 

  2. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Amstrong D, Ducy P, Karsenty G (2002) Leptin regulates bone formation via the sympathetic nervous system. Cell 111:305–317

    Article  CAS  PubMed  Google Scholar 

  3. He JY, Jiang LS, Dai LY (2011) The roles of the sympathetic nervous system in osteoporotic diseases: a review of experimental and clinical studies. Ageing Res Rev 10:253–263

    Article  CAS  PubMed  Google Scholar 

  4. Rejnmark L, Vestergaard P, Kassem M, Christoffersen BR, Kolthoff N, Brixen K, Mosekilde L (2004) Fracture risk in perimenopausal women treated with beta-blockers. Calcif Tissue Int 75:365–372

    Article  CAS  PubMed  Google Scholar 

  5. Levasseur R, Dargent-Molina P, Sabatier JP, Marcelli C, Breart G (2005) Beta-blocker use, bone mineral density, and fracture risk in older women: results from the Epidemiologie de l’Osteoporose prospective study. J Am Geriatr Soc 53:550–552

    Article  PubMed  Google Scholar 

  6. Reid IR, Gamble GD, Grey AB, Black DM, Ensrud KE, Browner WS, Bauer DC (2005) beta-blocker use, BMD, and fractures in the study of osteoporotic fractures. J Bone Miner Res 20:613–618

    Article  CAS  PubMed  Google Scholar 

  7. Sosa M, Saavedra P, Gomez de Tejada MJ, Mosquera J, Perez-Cano R, Olmos JM, Munoz-Torres M, Amerigo ML, Moro MJ, Diaz-Curiel M, Alegre J, Malouf J, Del Pino J, Nogues X, Torrijos A, GIUMO Cooperative Group (2011) Beta-blocker use is associated with fragility fractures in postmenopausal women with coronary heart disease. Aging Clin Exp Res 23:112–117

  8. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 93:1043–1065

    Google Scholar 

  9. Kimura T, Matsumoto T, Akiyoshi M, Owa Y, Miyasaka N, Aso T, Moritani T (2006) Body fat and blood lipids in postmenopausal women are related to resting autonomic nervous system activity. Eur J Appl Physiol 97:542–547

    Article  CAS  PubMed  Google Scholar 

  10. Matsumoto T, Miyawaki T, Ue H, Kanda T, Zenji C, Moritani T (1999) Autonomic responsiveness to acute cold exposure in obese and non-obese young women. Int J Obes Relat Metab Disord 23:793–800

    Article  CAS  PubMed  Google Scholar 

  11. Amano M, Kanda T, Ue H, Moritani T (2001) Exercise training and autonomic nervous system activity in obese individuals. Med Sci Sports Exerc 33:1287–1291

    Article  CAS  PubMed  Google Scholar 

  12. Kim KZ, Shin A, Lee J, Myung SK, Kim J (2012) The beneficial effect of leisure-time physical activity on bone mineral density in pre- and postmenopausal women. Calcif Tissue Int 91:178–185

    Article  CAS  PubMed  Google Scholar 

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All authors have no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatric, Perinatal and Maternal Medicine, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-5819, Japan

    Naoyuki Miyasaka

  2. Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-5819, Japan

    Mihoko Akiyoshi & Toshiro Kubota

Authors
  1. Naoyuki Miyasaka
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  2. Mihoko Akiyoshi
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  3. Toshiro Kubota
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Correspondence to Naoyuki Miyasaka.

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Miyasaka, N., Akiyoshi, M. & Kubota, T. Relationship between autonomic nervous system activity and bone mineral density in non-medicated perimenopausal women. J Bone Miner Metab 32, 588–592 (2014). https://doi.org/10.1007/s00774-013-0534-x

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  • DOI: https://doi.org/10.1007/s00774-013-0534-x

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