Skip to main content

Advertisement

SpringerLink
Log in

Zoledronic acid in treatment of bone lesions by Langerhans cell histiocytosis

  • Short Communication
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Langerhans cell histiocytosis (LCH) is a rare disease, probably an atypical myeloproliferative syndrome, with variable clinical presentation and behavior. In this report, we focus on bone involvement by LCH and treatment with zoledronic acid in six patients as they progressed after chemotherapy and radiotherapy. Zoledronic acid appeared safe and produced significant relief in pain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Arceci RJ (2002) Langerhans cell histiocytosis in children and adults: pathogenesis, clinical manifestations, and treatment. Hematology (Am Soc Hematol Educ Program) 1:297–304

    Google Scholar 

  2. Histiocytosis Association of America. http://www.histio.org. Cited July 2007

  3. Gadner H, Grois N, Arico M, Broadbent V, Ceci A, Jakobson A, Komp D, Michaelis J, Nicholson S, Pötschger U, Pritchard J, Ladisch S, Histiocyte Society (2001) A randomized trial of treatment for multisystem Langerhans cell histiocytosis. Pediatrics 138:728–734

    Article  CAS  Google Scholar 

  4. Baumgartner I, von Hochstetter A, Baumert B, Luetolf U, Follath F (1997) Langerhans’-cell histiocytosis in adults. Med Pediatr Oncol 28:9–14

    Article  PubMed  CAS  Google Scholar 

  5. Montella L, Insabato L, Palmieri G (2004) Imatinib mesylate for cerebral Langerhans’-cell histiocytosis. N Engl J Med 351:1034–1035

    Article  PubMed  CAS  Google Scholar 

  6. Lau LM, Stuurman K, Weitzman S (2008) Skeletal Langerhans cell histiocytosis in children: permanent consequences and health-related quality of life in long-term survivors. Pediatr Blood Cancer 50(3):607–612

    Article  PubMed  Google Scholar 

  7. García de Marcos JA, Ferrer AD, Granados FA, Masera JJR, Sánchez GB, Ortiz AIR, Calderón Bohórquez JM, Salas BV (2007) Langerhans cell histiocytosis in the maxillofacial area in adults. Report of three cases. Med Oral Patol Oral Cir Bucal 12:E145–E150

    PubMed  Google Scholar 

  8. Arzoo K, Sadeghi S, Pullarkat V (2001) Pamidronate for bone pain from osteolytic lesions in Langerhans’-cell histiocytosis. N Engl J Med 345:225

    Article  PubMed  CAS  Google Scholar 

  9. Farran RP, Zaretski E, Egeler RM (2001) Treatment of Langerhans cell histiocytosis with pamidronate. Pediatr Hematol Oncol 23:54–56

    Article  CAS  Google Scholar 

  10. Kamizono J, Okada Y, Shirahata A, Tanaka Y (2002) Bisphosphonate induces remission of refractory osteolysis in langerhans cell histiocytosis. J Bone Miner Res 17:1926–1928

    Article  PubMed  Google Scholar 

  11. Coleman RE (2004) Bisphosphonates: clinical experience. Oncologist 9(suppl 4):14–27

    Article  PubMed  CAS  Google Scholar 

  12. Green JR (2004) Bisphosphonates: preclinical review. Oncologist 9(suppl 4):3–13

    Article  PubMed  CAS  Google Scholar 

  13. Egeler RM, Favara BE, van Meurs M, Laman JD, Claassen E (1999) Differential in situ cytokine profiles of Langerhans-like cells and T cells in Langerhans cell histiocytosis: abundant expression of cytokines relevant to disease and treatment. Blood 94:4195–4201

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Oncology Unit, S. Giovanni di Dio Hospital, Frattamaggiore, Naples, Italy

    Liliana Montella

  2. Casa di Cura Villa Maria, Mirabella Eclano, Avellino, Italy

    Carmela Merola & Giovannella Palmieri

  3. Molecular and Clinical Endocrinology and Oncology Department, Federico II University, Naples, Italy

    Geraldina Merola, Luigi Petillo & Giovannella Palmieri

Authors
  1. Liliana Montella
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carmela Merola
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Geraldina Merola
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Luigi Petillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giovannella Palmieri
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Liliana Montella or Giovannella Palmieri.

About this article

Cite this article

Montella, L., Merola, C., Merola, G. et al. Zoledronic acid in treatment of bone lesions by Langerhans cell histiocytosis. J Bone Miner Metab 27, 110–113 (2009). https://doi.org/10.1007/s00774-008-0001-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00774-008-0001-2

Keywords

Search

Navigation