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Neuroendokrine Neoplasien des gastroenteropankreatischen Systems

Pathologie und Klassifikation

Neuroendocrine neoplasia of the gastroenteropancreatic system

Pathology and classification

  • Leitthema
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Der Onkologe Aims and scope

Zusammenfassung

Neuroendokrine Neoplasien (NEN) sind eine morphologisch homogen erscheinende, biologisch und klinisch jedoch sehr heterogene Tumorgruppe. NEN können in jedem inneren Organ auftreten, am häufigsten sind sie jedoch in der Lunge und im gastroenteropankreatischen (GEP) System. Um die Diagnostik und Klassifikation der GEP-NEN zu vereinheitlichen und zu verbessern, wurden durch die European Neuroendocrine Tumor Society (ENETS) in den letzten 5 Jahren Leitlinien erarbeitet. Unter Berücksichtigung dieser Leitlinien wurde 2009 die TNM-Klassifikation der Union for International Cancer Control (UICC) vorgestellt. 2010 schließlich folgte eine neue Klassifikation der GEP-NEN durch die Weltgesundheitsorganisation (WHO). Diese Übersicht fasst die neue Klassifikation und morphologische Diagnostik der GEP-NEN zusammen. Auf dieser Basis ist eine ausgezeichnete Prognoseeinsschätzung der GEP-NEN möglich. Sie bestimmt die Auswahl der Bildgebung und der Behandlungsoptionen und sichert außerdem die Vergleichbarkeit von größeren Tumorkollektiven.

Abstract

Neuroendocrine neoplasms (NEN) appear to be morphologically homogeneous, however, biologically and clinically they are a very heterogeneous tumor group. They can occur in every organ but are most common in the lungs and the gastroenteropancreatic system (GEP). In order to unify and improve the diagnosis and therapy of GEP-NEN the European Neuroendocrine Tumor Society (ENETS) has developed guidelines over the last 5 years. In consideration of these guidelines the TNM classification of the Union for International Cancer Control (UICC) was introduced in 2009 and only 1 year later the new GEP-NEN classification of the World Health Organization (WHO) was presented. This review summarizes the new classification and the morphological diagnosis of GEP-NEN. Based on these classifications an optimal prognostic stratification of GEP-NEN is possible which is the basis for imaging and treatment and allows a comparison of large tumor collectives.

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Authors and Affiliations

  1. Institut für Pathologie und Endokrines Tumorzentrum, Universitätsklinikum Düsseldorf, 40225, Düsseldorf, Deutschland

    M. Anlauf & P. Gerlach

  2. Klinik für Allgemein-, Visceral- und Kinderchirurgie und Endokrines Tumorzentrum, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    A. Raffel

  3. Klinik für Endokrinologie, Diabetologie und Rheumatologie und Endokrines Tumorzentrum, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    M. Schott

  4. Klinik für Nuklearmedizin und ENETS Center of Excellence, Zentralklinik Bad Berka, Bad Berka, Deutschland

    R. Baum

  5. Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie und ENETS Center of Excellence, Campus Virchow Klinikum, Berlin, Deutschland

    M. Pavel

  6. Institut für Pathologie und Konsultationszentrum für Pankreas und Neuroendokrine Tumoren, Universitätsklinikum Rechts der Isar, TU München, Deutschland

    G. Klöppel

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  1. M. Anlauf
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  2. P. Gerlach
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  3. A. Raffel
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  4. M. Schott
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  5. R. Baum
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  6. M. Pavel
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  7. G. Klöppel
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Correspondence to M. Anlauf.

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Anlauf, M., Gerlach, P., Raffel, A. et al. Neuroendokrine Neoplasien des gastroenteropankreatischen Systems. Onkologe 17, 572–582 (2011). https://doi.org/10.1007/s00761-011-2052-6

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  • DOI: https://doi.org/10.1007/s00761-011-2052-6

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