Abstract
Postpartum psychosis is a serious disorder that can cause negative consequences for the mother, infant, and entire family. While reports of this condition date back for centuries, little is known about what interventions are most effective for this population. The purpose of this systematic review was to examine the research evidence on interventions for the prevention and treatment of postpartum psychosis. Studies were searched using CINAHL, EMBASE, MEDLINE, PsycINFO, and PubMed databases. All primary research studies published in English since 1970 that explored interventions for the prevention or treatment of postpartum psychosis were included. The search resulted in 26 studies on interventions for postpartum psychosis, with 10 focusing on prevention and 17 focusing on treatment. Studies on the prevention of postpartum psychosis have examined the effects of mood stabilizers, antipsychotics, and hormone therapy, while those examining treatment have included electroconvulsive therapy, mood stabilizers, antipsychotics, hormones, and the beta blocker propranolol. Only preliminary evidence suggests which interventions may be effective strategies to prevent (e.g., lithium) and treat (e.g., electroconvulsive therapy) postpartum psychosis. Due to methodological limitations in the studies reviewed, extensive evidence-based recommendations for the prevention and treatment of postpartum psychosis cannot be made. The known risk factors and negative consequences of postpartum psychosis point to the importance of preventative and acute treatment measures. Well-designed prospective studies are needed to determine the efficacy of prevention and treatment interventions for women who experience postpartum psychosis.
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Abou-Saleh MT, Coppen A (1983) Puerperal affective disorders and response to lithium. Br J Psychiatry 142:539
Ahokas A, Aito M (1999) Role of estradiol in puerperal psychosis. Psychopharmacology 147:108–110
Ahokas A, Aito M, Rimon R (2000a) Positive treatment effect of estradiol in postpartum psychosis: a pilot study. J Clin Psychiatry 61:166–169
Ahokas A, Aito M, Turtiainen S (2000b) Association between oestradiol and puerperal psychosis. Acta Psychiatr Scand 101:167–170
American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, text revision
Appleby L, Mortensen PB, Faragher EB (1998) Suicide and other causes of mortality after post-partum psychiatric admission. Br J Psychiatry 173:209–211
Atkinson S, Atkinson T (1983) Puerperal psychosis: a personal experience. Health Visit 56:17–19
Austin MV (1992) Puerperal affective psychosis: is there a case for lithium prophylaxis? Br J Psychiatry 161:692–694
Brockington IF (1996) Motherhood and mental health. Oxford University Press, Oxford
Brockington IF, Cernik KF, Schofield EM, Downing AR, Francis AF, Keelan C (1981) Puerperal psychosis: phenomena and diagnosis. Arch Gen Psychiatry 38:829–833
Chandra PS, Bhargavaraman RP, Raghunandan VNGP, Shaligram D (2006) Delusions related to infant and their association with mother–infant interactions in postpartum psychotic disorders. Arch Womens Ment Health 9:285–288
Cohen LS, Sichel DA, Robertson LM, Heckscher E, Rosenbaum JF (1995) Postpartum prophylaxis for women with bipolar disorder. Am J Psychiatry 152:1641–1645
Forray A, Ostroff RB (2007) The use of electroconvulsive therapy in postpartum affective disorders. J ECT 23:188–193
Heron J, Robertson-Blackmore E, McGuinness M, Craddock N, Jones I (2007) No latent period in bipolar affective puerperal psychosis. Arch Womens Ment Health 10:79–81
Heron J, McGuinness M, Robertson Blackmore E, Craddock N, Jones I (2008) Early postpartum symptoms in puerperal psychosis. Br J Obstet Gynaecol 115:348–353
Hipwell AE, Goossens FA, Melhuish EC, Kumar R (2000) Severe maternal psychopathology and infant–mother attachment. Dev Psychopathol 12:157–175
Huang MC, Wang YB, Chan CH (2008) Estrogen-progesterone combination for treatment-refractory post-partum mania. Psychiatry Clin Neurosci 62:126
Iruela LM, Ibañez-Rojo V, Gilaberte I, Oliveros SC (1992) New possible indications of pimozide. J Clin Psychiatry 53:172–173
Jones I, Craddock N (2001) Familiarity of the puerperal trigger in bipolar disorder: results of a family study. Am J Psychiatry 158:913–917
Kendell R, Chalmers J, Platz C (1987) Epidemiology of puerperal psychoses. Br J Psychiatry 150:662–673
Kornhuber J, Weller M (1991) Postpartum psychosis and mastitis: a new indication for clozapine? Am J Psychiatry 148:1751–1752
Kumar C, McIvor RJ, Davies T (2003) Estrogen administration does not reduce the rate of recurrence of affective psychosis after childbirth. J Clin Psychiatry 64:112–118
Lichtenberg P, Navon R, Wertman E, Dasberg H, Lerer B (1988) Post-partum psychosis in adult GM2 Gangliosidosis: a case report. Br J Psychiatry 153:387–389
Marshall S, Nursing care study (1981) Puerperal psychosis: with a lot of help from her friends. Nurs Mirror 152:46–47
Munk-Olsen T, Laursen TM, Pedersen CB, Mors O, Mortensen PB (2006) New parents and mental disorders: a population-based register study. JAMA 296:2582–2589
Murray D (1990) Recurrence of puerperal psychosis not prevented by prophylactic progesterone administration. J Nerv Ment Dis 178:537–538
O’Hara MW, Swain AM (1996) Rates and risk of postpartum depression: a meta-analysis. Int Rev Psychiatry 8:37–54
O’Reagan JB (1981) Treatment of acute postpartum psychosis. Can Med Assoc J 125:1083
Prichard BNC, Gillam PMS (1996) Treatment of hypertension with propranolol. Br Med J 1:7–16
Reed P, Sermin N, Appleby L, Faragher B (1999) A comparison of clinical response to electroconvulsive therapy in puerperal and non-puerperal psychoses. J Affect Disord 54:255–260
Robertson E, Jones I, Haque S, Holder R, Craddock N (2005) Risk of puerperal and non-puerperal recurrence of illness following bipolar affective puerperal (post-partum) psychosis. Br J Psychiatry 186:258–259
Sharma V (2003) Pharmacotherapy of postpartum psychosis. Expert Opin Pharmacother 4:1651–1658
Sharma V, Smith A, Mazmanian D (2006) Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder. Bipolar Disord 8:400–404
Sichel DA, Cohen LS, Robertson LM, Ruttenberg A, Rosenbaum JF (1995) Prophylactic estrogen in recurrent postpartum affective disorder. Biol Psychiatry 38:814–818
Silbermann RM, Beenen F, de Jong H (1975) Clinical treatment of post partum delirium with perfenazine and lithium carbonate. Psychiatr Clin 8:314–326
Sit D, Rothschild AJ, Wisner KL (2006) A review of postpartum psychosis. J Womens Health 15:352–368
Spinelli MG (2004) Maternal infanticide associated with mental illness: prevention and promise of saved lives. Am J Psychiatry 161:1548–1557
Stanworth HM (1982) After-care of puerperal psychosis in the community. Nurs Times 78:922–925
Steiner M, Latz A, Blum I, Atsmon A, Wijsenbeek H (1973) Propranolol versus chlorpromazine in the treatment of psychoses associated with childbearing. Psychiatr Neurol Neurochir 76:421–426
Stewart DE (1988) Prophylactic lithium in postpartum affective psychosis. J Nerv Ment Dis 176:485–489
Stewart DE, Klompenhouwer JL, Kendall RE, Van Hulst AM (1991) Prophylactic lithium in puerperal psychosis: the experience of three centres. Br J Psychiatry 158:393–397
Stowe ZN (2007) The use of mood stabilizers during breastfeeding. J Clin Psychiatry 68(Suppl 9):22–28
Targum S, Davenport Y, Webster M (1979) Postpartum mania in bipolar manic-depressive patients withdrawn from lithium carbonate. J Nerv Ment Disord 167:572–574
Terp IM, Engholm G, Moller H, Mortenson PB (1999) A follow-up study of postpartum psychoses: prognosis and risk factors for readmission. Acta Psychiatr Scand 100:40–46
van Gent EM, Verhoeven WM (1992) Bipolar illness, lithium prophylaxis, and pregnancy. Pharmacopsychiatry 25:187–191
Viguera AC, Nonacs R, Cohen LS, Tondo L, Murray A, Baldessarini RJ (2000) Risk of recurrence of bipolar disorder in pregnant and nonpregnant women after discontinuing lithium maintenance. Am J Psychiatry 157:179–184
Wisner KL, Hanusa BH, Peindl KS, Perel JM (2004) Prevention of postpartum episodes in women with bipolar disorder. Biol Psychiatry 56:592–596
World Health Organization (1992) The ICD-10 Classification of Mental and Behavioral Disorders. World Health Organization, Geneva
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Doucet, S., Jones, I., Letourneau, N. et al. Interventions for the prevention and treatment of postpartum psychosis: a systematic review. Arch Womens Ment Health 14, 89–98 (2011). https://doi.org/10.1007/s00737-010-0199-6
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DOI: https://doi.org/10.1007/s00737-010-0199-6