Abstract
To determine the prevalence of use of atypical antipsychotics in pregnancy and describe infant outcomes associated with these exposures. A retrospective chart review of all pregnant women presenting at our medical center, from the years 1993 to 2007, was conducted. 30,092 total deliveries during that time period were identified. 16 mothers were treated with atypical antipsychotics during their pregnancy. The medical charts of the infants exposed to atypical antipsychotics during pregnancy were reviewed to determine their outcomes, including gestational age, birth weight, and malformations. Only 16 (0.053%) of the women took an atypical antipsychotic at some point during the antenatal period. Average gestational age was 37 5/7 weeks with a standard deviation of 2.54 days. Average birth weight was 3,188 g with a standard deviation of 615 g, which is appropriate for early gestational age. One (6.25%) major malformation was noted. Additional studies need to be completed regarding the effect of atypical antipsychotic use in pregnancy and outcomes related to gestational age, birth weight and malformations.
Similar content being viewed by others
References
Bennedsen BE, Mortenson PB, Olesen AV et al (1999) Preterm birth and intrauterine growth retardation among children of women with schizophrenia. Br J Psychiatry 175:239–245
Coppola D, Russo LJ, Kwarta RF et al (2007) Evaluating the postmarketing experience of risperidone use during pregnancy. Drug Safety 30:247–264
Doubilet PM, Benson CB, Nadel AS et al (1997) Improved birth weight table for neonates developed from gestations dated by early ultrasonography. J Ultrasound Med 16:241
Howard LM, Goss C, Leese M et al (2003) Medical outcome of pregnancy in women with psychotic disorder and their infants in the first year after birth. Br J Psychiatry 182:63–67
McKenna K, Koren G, Tetelbaum M et al (2005) Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study. J Clin Psych 66:444–449
Mendhekar DN, Sunder KR, Andrade C (2006a) Aripiprazole use in a pregnant schizoaffective woman. Bipolar Disord 8:299–300
Mendhekar DN, Sharma JB, Srilakshmi P (2006b) Use of aripiprazole during late pregnancy in a woman with psychotic illness. Ann Pharmacother 40:575
Mervak B, Collins J, Valenstein M (2008) Case report of aripiprazole usage during pregnancy. Arch Womens Ment Health 11:249–250
Newharm JJ, Thoams SH, MacRitchie K et al (2008) Birth weight of infants after maternal exposure to typical and atypical antipsychotics: prospective comparison study. Brit J Psych 192:333–337
Newport D, Calamaras MR, DeVane CL et al (2007) Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. Am J Psych 164:1214–1220
Orr ST, Miller CA (1995) Maternal depressive symptoms and the risk of poor pregnancy outcome: Review of the literature and preliminary findings. Epidem Reviews 17:165–171
Sacker A, Done DJ, Crow TJ (1996) Obstetric complications in children born to parents with schizophrenia: a meta-analysis of case-control studies. Psychol Med 26:279–287
Steer RA, Scholl TO, Hediger ML et al (1992) Self-reported depression and negative pregnancy outcomes. J Clin Epidem 45:1093–1030
Zuckerman B, Bauchner H, Parker S et al (1990) Maternal depressive symptoms during pregnancy, and newborn irritability. J Develop Behav Ped 11:190–194
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wichman, C.L. Atypical antipsychotic use in pregnancy: a retrospective review. Arch Womens Ment Health 12, 53–57 (2009). https://doi.org/10.1007/s00737-008-0044-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00737-008-0044-3