Summary
Antiepileptic drugs (AEDs) are teratogenic. The aim of this survey was to ascertain whether clinicians followed recently published guidelines for prescribing AEDs to women of childbearing potential in England and Wales. We reviewed the case notes of all women aged 16–47 years who were initiated on valproate or carbamazapine in the psychiatric departments of three teaching hospitals over a 12 month period. Standards of documentation regarding childbearing issues in this representative sample were poor. The results are of concern given the widespread use of antiepileptic drugs in psychiatry.
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References
N Adab U Kini J Vinten et al. (2004) ArticleTitleThe longer term outcome of children born to mothers with epilepsy J Neurol Neurosurg Psychiatry 75 1575–1583 Occurrence Handle15491979 Occurrence Handle10.1136/jnnp.2003.029132 Occurrence Handle1:STN:280:DC%2BD2critFCktg%3D%3D
American Psychiatric Association (2002) Practice guideline for the treatment of patients with bipolar disorder, 2nd edn. Washington, DC.
S Fried E Kozer I Nulman et al. (2004) ArticleTitleMalformation rates in children of women with untreated epilepsy: a meta-analysis Drug Saf 27 197–202 Occurrence Handle14756581 Occurrence Handle10.2165/00002018-200427030-00004
GM Goodwin AH Young (2003) ArticleTitleThe British Association for Psychopharmacology guidelines for treatment of bipolar disorder: a summary J Psychopharmacol 17 IssueIDSuppl 4 3–6 Occurrence Handle14964624
Lumley J, Watson L, Watson M, Bower C (2001) Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects. Cochrane Database Systematic Reviews, Chichester, U.K.
S Matalon S Schechtman G Goldzweig et al. (2002) ArticleTitleThe teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures Reprod Toxicol 16 9–17 Occurrence Handle11934528 Occurrence Handle10.1016/S0890-6238(01)00199-X Occurrence Handle1:CAS:528:DC%2BD38XisV2ktb4%3D
Medicines and Healthcare Products Regulatory Agency, Committee on Safety of Medicines (2003) Current problems in pharmacovigilance. Sodium valproate and prescribing in pregnancy, vol 29. pp 6–7. http://medicines.mhra.gov.uk/monitorsafequalmed/currentproblems/currentproblems.htm.
National Institute for Clinical Excellence (2004) The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. Clinical guideline 20 (Published October 2004). http://www.nice.org.uk.
National Institute for Health and Clinical Excellence (2006) Bipolar disorder. The management of bipolar disorder in adults, children and adolescents, in primary and secondary care. Clinical guideline 38. www.nice.org.uk.
K Nelson LG Holmes (1989) ArticleTitleMalformations due to presumed spontaneous mutations in newborn infants N Engl J Med 320 19–23 Occurrence Handle2909875 Occurrence Handle1:STN:280:DyaL1M%2Fot1Grsw%3D%3D Occurrence Handle10.1056/NEJM198901053200104
E Perucca (2005) ArticleTitleBirth defects after prenatal exposure to antiepileptic drugs Lancet Neurol 4 781–786 Occurrence Handle16239185 Occurrence Handle10.1016/S1474-4422(05)70224-6 Occurrence Handle1:CAS:528:DC%2BD2MXht1eks7vL
EB Samren CM Duijn S Koch et al. (1997) ArticleTitleMaternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis Epilepsia 38 981–990 Occurrence Handle9579936 Occurrence Handle10.1111/j.1528-1157.1997.tb01480.x Occurrence Handle1:STN:280:DyaK1c3jvFGguw%3D%3D
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Wieck, A., Rao, S., Sein, K. et al. A survey of antiepileptic prescribing to women of childbearing potential in psychiatry. Arch Womens Ment Health 10, 83–85 (2007). https://doi.org/10.1007/s00737-007-0175-y
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DOI: https://doi.org/10.1007/s00737-007-0175-y