Abstract
Heart failure is a complex pathophysiological syndrome of pumping functional failure that results from injury, infection or toxin-induced damage on the myocardium, as well as genetic influence. Gene mutations associated with cardiomyopathies can lead to various pathologies of heart failure. In recent years, zebrafish, Danio rerio, has emerged as an excellent model to study human cardiovascular diseases such as congenital heart defects, cardiomyopathy, and preclinical development of drugs targeting these diseases. In this review, we will first summarize zebrafish genetic models of heart failure arose from cardiomyopathy, which is caused by mutations in sarcomere, calcium or mitochondrial-associated genes. Moreover, we outline zebrafish heart failure models triggered by chemical compounds. Elucidation of these models will improve the understanding of the mechanism of pathogenesis and provide potential targets for novel therapies.
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Abbreviations
- HCM:
-
Hypertrophic cardiomyopathy
- DCM:
-
Dilated cardiomyopathy
- hpf:
-
Hours post fertilization
- Cmlc2:
-
Cardiac myosin light chain-2
- Mybpc3:
-
Myosin binding protein C
- SERCA2:
-
Sarco-endoplasmic reticular Ca2+-ATPase2
- NCX1:
-
Sodium calcium exchanger
- ORAI1:
-
Calcium-release-activated calcium channel protein 1
- ISO:
-
Isoproterenol
- AA:
-
Aristolochic acid
- DOX:
-
Doxorubicin
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Acknowledgements
This work was supported by the National Natural Science Foundation of China grants 81770381 (X.S.), 81270295 (X.L.); Key R&D Program of Jiangsu Province SBE2017740378 (X.L.), the Fundamental Research Funds for the Central Universities, and the grant from Innovation Center for Cardiovascular Disease Translational Medicine of Jiangsu Province.
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XS and XYW conceived and designed the paper; XS and RC interpreted data and drafted the manuscript; XS and JY prepared the figures; YZ, KBA and XL revised the manuscript.
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Shi, X., Chen, R., Zhang, Y. et al. Zebrafish heart failure models: opportunities and challenges. Amino Acids 50, 787–798 (2018). https://doi.org/10.1007/s00726-018-2578-7
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DOI: https://doi.org/10.1007/s00726-018-2578-7