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Inhibition of AGEs formation by natural products

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Abstract

Since advanced glycation end-products (AGEs) inhibitors such as benfotiamine, pyridoxamine and aminoguanidine significantly inhibit the development of retinopathy and neuropathy in streptozotocin-induced diabetic rats, treatment with AGEs inhibitors is believed to be a potential strategy for preventing lifestyle-related diseases such as diabetic complications and atherosclerosis. Furthermore, preventive medicine is the most important approach to preventing lifestyle-related diseases, and improving daily nutritional intake is thought to prevent the pathogenesis of such diseases. Therefore, AGEs inhibitors that can be obtained from daily meals are preferred to prescribed drugs. In this article, we describe a strategy for developing new AGEs inhibitors from natural products.

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Acknowledgments

This work was supported in part by Grants-in-Aid for Scientific Research (No. 24300260 and 24650482 to Ryoji Nagai) from the Ministry of Education, Science, Sports and Culture of Japan.

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Authors and Affiliations

  1. Laboratory of Food and Regulation Biology Department of Bioscience, School of Agriculture, Tokai University, Kawayou Minamiaso Aso-gun, Kumamoto, 869-1404, Japan

    Ryoji Nagai, Jun-ichi Shirakawa, Rei-ichi Ohno, Narumi Moroishi & Mime Nagai

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  1. Ryoji Nagai
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  2. Jun-ichi Shirakawa
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  3. Rei-ichi Ohno
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  4. Narumi Moroishi
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  5. Mime Nagai
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Correspondence to Ryoji Nagai.

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Nagai, R., Shirakawa, Ji., Ohno, Ri. et al. Inhibition of AGEs formation by natural products. Amino Acids 46, 261–266 (2014). https://doi.org/10.1007/s00726-013-1487-z

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  • DOI: https://doi.org/10.1007/s00726-013-1487-z

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