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Increasing effects of S-methyl-l-cysteine on the extracellular d-serine concentrations in the rat medial frontal cortex

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Abstract

In an in vivo dialysis experiment, the intra-medial frontal cortex infusion of a system A and Asc-1 transporter inhibitor, S-methyl-l-cysteine, caused a concentration-dependent increase in the dialysate contents of an endogenous coagonist for the N-methyl-d-aspartate (NMDA) type glutamate receptor, d-serine, in the cortical portion. These results suggest that these neutral amino acid transporters could control the extracellular d-serine signaling in the brain and be a target for the development of a novel threapy for neuropsychiatric disorders with an NMDA receptor dysfunction.

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Acknowledgments

This work was supported by the CREST (Core Research for Evolutional Science and Technology) program funded by the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Author notes

  1. Yasushi Kajii

    Present address: Scientific Project Group, Medical, AbbVie GK, 3-5-27, Mita, Minato-ku, Tokyo, 108-6302, Japan

Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Sayuri Ishiwata, Shigehiro Ogata, Asami Umino, Hirohisa Shiraku & Toru Nishikawa

  2. Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, 227-0033, Japan

    Yoshitaka Ohashi & Yasushi Kajii

Authors
  1. Sayuri Ishiwata
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  2. Shigehiro Ogata
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  3. Asami Umino
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  4. Hirohisa Shiraku
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  5. Yoshitaka Ohashi
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  6. Yasushi Kajii
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  7. Toru Nishikawa
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Corresponding author

Correspondence to Toru Nishikawa.

Additional information

These authors Sayuri Ishiwata and Shigehiro Ogata have contributed equally to this work.

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Ishiwata, S., Ogata, S., Umino, A. et al. Increasing effects of S-methyl-l-cysteine on the extracellular d-serine concentrations in the rat medial frontal cortex. Amino Acids 44, 1391–1395 (2013). https://doi.org/10.1007/s00726-013-1464-6

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  • DOI: https://doi.org/10.1007/s00726-013-1464-6

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