Abstract
The increasing resistance of bacteria and fungi to currently available antibiotics is a major concern worldwide, leading to enormous efforts to develop new antibiotics with new modes of actions. Antibacterial peptide CM4 (ABP-CM4) is a small cationic peptide with broad-spectrum activities against bacteria, fungi, and tumor cells, which may possibly be used as a promising candidate for a new antibiotic. For pharmaceutical applications, a large quantity of antimicrobial peptides needs to be produced economically. In this communication, the progress in the structural characteristics, heterologous production, and biological evaluation of ABP-CM4 are reviewed.
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Published data referred to in this manuscript were supported by a grant of the National Natural Science Foundation of China (Grant No. 30900743) and A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
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Li, J.F., Zhang, J., Xu, X.Z. et al. The antibacterial peptide ABP-CM4: the current state of its production and applications. Amino Acids 42, 2393–2402 (2012). https://doi.org/10.1007/s00726-011-0982-3
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DOI: https://doi.org/10.1007/s00726-011-0982-3