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Creatine as an antioxidant

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Abstract

Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP system. Indeed, a wide number of research articles indicate that Cr is capable of exerting multiple, non-energy related, effects on diverse and relevant cellular targets. Among these effects, the antioxidant activity of Cr emerges as an additional mechanism which is likely to play a supportive role in the Cr-cytoprotection paradigm.

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  1. Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino “Carlo Bo”, Via Saffi, 2, 61029, Urbino, Italy

    Piero Sestili, C. Martinelli, E. Colombo, E. Barbieri & L. Potenza

  2. Dipartimento di Scienze della Terra, della Vita e dell’Ambiente (DiSTeVA), Università degli Studi di Urbino “Carlo Bo”, Campus Scientifico, 61029, Urbino, Italy

    S. Sartini

  3. Dipartimento di Farmacologia, Università degli Studi di Bologna, Via Irnerio 48, 40126, Bologna, Italy

    C. Fimognari

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  1. Piero Sestili
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  2. C. Martinelli
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Correspondence to Piero Sestili.

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Sestili, P., Martinelli, C., Colombo, E. et al. Creatine as an antioxidant. Amino Acids 40, 1385–1396 (2011). https://doi.org/10.1007/s00726-011-0875-5

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