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Effect of taurine on alcoholic liver disease in rats

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Abstract

To investigate the effect of taurine on alcoholic liver disease in rats, male Wistar rats were administered alcohol intragastrically for 3 months. The effect of β-alanine-mediated taurine depletion and taurine administration on the development of alcoholic liver disease was examined. It was found that taurine administration produced lower levels of aspartate aminotransferase and alkaline aminotransferase than that of the untreated group. In addition, the levels of hepatic total protein, glutathione and superoxide dismutase were higher in the taurine treated groups than those in the untreated control or the taurine depleted groups, while hepatic malondialdehyde content exhibited the negative effect. Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-α and laminin were all decreased in the taurine treated groups. The pathological changes showed that the percentage of fatty degeneration and inflammation in the taurine groups were lower than that of the control, taurine depleted and automatic recovery groups. These in vivo findings demonstrate that hepatic disease caused by chronic alcohol consumption can be prevented and cured by administration of taurine.

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Acknowledgments

This study was supported by a grant from the Education Department of Liaoning Province, China. The authors thank Dr. Masugi Nishihara, Tokyo University (Japan) for reviewing the manuscript and giving valuable advice.

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Authors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China

    Gaofeng Wu, Jiancheng Yang, Xinhong Luan, Jiao Shi & Jianmin Hu

  2. College of Animal Science, China Agricultural University, Beijing, China

    Changmian Sun

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  1. Gaofeng Wu
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  2. Jiancheng Yang
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  3. Changmian Sun
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  4. Xinhong Luan
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  5. Jiao Shi
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  6. Jianmin Hu
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Correspondence to Jianmin Hu.

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Wu, G., Yang, J., Sun, C. et al. Effect of taurine on alcoholic liver disease in rats. Amino Acids 36, 457–464 (2009). https://doi.org/10.1007/s00726-008-0101-2

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  • DOI: https://doi.org/10.1007/s00726-008-0101-2

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