Summary.
Dityrosine is found in several proteins as a product of UV irradiation, γ-irradiation, aging, exposure to oxygen free radicals, nitrogen dioxide, peroxynitrite, and lipid hydroperoxides. Interest of dityrosine in proteins is based on its potential as a specific marker for oxidatively damaged proteins and their selective proteolysis, hence it could be used as a marker for oxidative stress. Dityrosine is also the product of normal post-translational processes affecting specific structural proteins. Since post-translational modification of a given amino acid in a protein is equivalent to the substitution of that residue by an analogue, it has been proposed that the covalent modification of amino acids may serve as a “marking” step for protein degradation.
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Giulivi, C., Traaseth, N. & Davies, K. Tyrosine oxidation products: analysis and biological relevance. Amino Acids 25, 227–232 (2003). https://doi.org/10.1007/s00726-003-0013-0
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DOI: https://doi.org/10.1007/s00726-003-0013-0