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Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging

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Abstract

The action of tryptanthrin, a known natural alkaloid, a potent inhibitor of cyclooxygenase COX-2 and 5-lipoxygenase, was studied in a model of dextran sodium sulfate (DSS)-induced mouse colitis by magnetic resonance imaging (MRI). It was shown that the intra-ventricular treatment with tryptanthrin suspensions or emulsion at a dose of 25 mg/kg effectively diminishes lethality at experimental groups and normalizes morphometric parameters of intestine in the treated animals. MR imaging confirmed anti-inflammatory effect of this alkaloid and its capability to decrease the size of bowel walls in animals with colitis.

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Authors and Affiliations

  1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 690022, Vladivostok, Russia

    Irina G. Agafonova

  2. Far East Federal University, 690000, Vladivostok, Russia

    Taisiya V. Moskovkina

Authors
  1. Irina G. Agafonova
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  2. Taisiya V. Moskovkina
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Correspondence to Irina G. Agafonova.

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Agafonova, I.G., Moskovkina, T.V. Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging. Appl Magn Reson 46, 781–791 (2015). https://doi.org/10.1007/s00723-015-0674-3

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  • DOI: https://doi.org/10.1007/s00723-015-0674-3

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