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Real-Time in Vitro Drug Dissolution Studies of Tablets Using Volume-Localized NMR (MRS)

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Abstract

An approach to measure in vitro drug dissolution rates employing spatially resolved nuclear magnetic resonance (NMR) is reported, as a complement to standard United States Pharmacopeia protocols. Measurements are performed under conditions that mimic the physiological (pH 1, temperature 37° C). In order to register realistic dissolution rates, the sample is stirred in the magnetic field, employing a setup that is described. While the stirrer in the sample cell does degrade spectral resolution even in volume-localized mode, it proves possible nevertheless to acquire ‘high resolution’ information. Measurements are performed employing ‘point resolved spectroscopy’ (PRESS) by tracking drug concentration in a selected voxel in the dissolution medium as a function of time. The dissolution of the tablets in vitro follows first-order kinetics under the non-sink conditions of these experiments, the measured rate constants reflecting characteristic differences in dissolution rates of different formulations. We supplement this study with diffusion-weighted imaging of water ingress into the tablets, confirming the trends.

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Acknowledgments

A.B. thanks the Council for Scientific and Industrial Research and the Indian Institute of Technology, Madras, for the grant of Senior Research Fellowship and of Research Assistantship, respectively; N.C. thanks the Department of Science and Technology and the Indian Institute of Technology, Madras for spectrometer grants. We thank Ms. Christy George, Senior Research Fellow, for her kind help with the manuscript revision.

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  1. Department of Chemistry, Indian Institute of Technology-Madras, Chennai, 600036, Tamil Nadu, India

    Abhishek Banerjee & N. Chandrakumar

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  1. Abhishek Banerjee
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  2. N. Chandrakumar
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Correspondence to N. Chandrakumar.

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Banerjee, A., Chandrakumar, N. Real-Time in Vitro Drug Dissolution Studies of Tablets Using Volume-Localized NMR (MRS). Appl Magn Reson 40, 251–259 (2011). https://doi.org/10.1007/s00723-011-0206-8

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  • DOI: https://doi.org/10.1007/s00723-011-0206-8

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