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Ultracompact NMR: 1H Spectroscopy in a Subkilogram Magnet

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Abstract.

We demonstrate the first subkilogram permanent magnet and microcoil probe combination capable of 1H nuclear magnetic resonance spectroscopy with subparts-per-million resolution. The 1 T magnet with a weight of 685 g utilizes steel pole faces and flux return paths to provide a sufficiently homogeneous magnetic field in a robust, easy-to-use device nearly immune to environmental influences. The microcoil probe provides a signal-to-noise ratio of 61 in a single data acquisition from 21 nanoliters of water. The line width achieved, 0.24 ppm, can be explained by the measured field variations across the sample volume. The device does not have shim coils, temperature insulation and control, or adequate radio frequency shielding, so simple improvements in these areas will lead to further increases in performance. When combined with commercially available miniaturized electronics, the magnet and the probe described here will form the first handheld device capable of 1H spectroscopy.

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References

  • Gil, A.M., Belton, P.S., Hills, B.P.: Annu. Rep. NMR Spectrosc. 32, 1–49 (1996)

    Article  Google Scholar 

  • Blümler, P., Blümich, B., Botto, R., Fukushima, E. (eds.): Spatially Resolved Magnetic Resonance. Wiley-VCH, New York (1998)

    Google Scholar 

  • Ruan, R.R., Chen, P.L.: NMR Approach. Technomic, Basel (1998)

    Google Scholar 

  • Coates, G.C., Xiao, L., Prammer, M.G.: NMR Logging Principles and Applications. Halliburton Energy Services, Houston (1999)

    Google Scholar 

  • Stapf, S., Han, S.-I.: NMR Imaging in Chemical Engineering. Wiley-VCH, Darmstadt (2006)

    Google Scholar 

  • Goloshevsky, A.G., Walton, J.H., Shutov, M.V., de Ropp, J.S., Collins, S.D., McCarthy, M.J.: Rev. Sci. Instrum. 76, 024101 (2005)

    Article  ADS  Google Scholar 

  • Moresi, G., Magin, R.: Concepts Magn. Reson. 19B, 35–43 (2003)

    Article  Google Scholar 

  • Raich, H., Blümler, P.: Concepts Magn. Reson. 23B, 16–25 (2004)

    Article  Google Scholar 

  • Eidmann, G., Savelsberg, R., Blümler, P., Blümich, B.: J. Magn. Reson. A 122, 104–109 (1996)

    Article  Google Scholar 

  • Kleinberg, R.L., Jackson, J.A.: Concepts Magn. Reson. 13, 340–342 (2001)

    Article  Google Scholar 

  • Manz, B., Coy, A., Dykstra, R., Eccles, C.D., Hunter, M.W., Parkinson, B.J., Callaghan, P.T.: J. Magn. Reson. 183, 25–31 (2006)

    Article  ADS  Google Scholar 

  • Hills, B.P., Wright, K.M.: J. Magn. Reson. 178, 193–205 (2006)

    Article  ADS  Google Scholar 

  • Goodson, B.: Phys. World 19, 28–33 (2006)

    Google Scholar 

  • www.cryogenic.co.uk

  • www.foxboronmr.com

  • Peck, T.L., Magin, R.L., Lauterbur, P.C.: J. Magn. Reson. B 108, 114–124 (1995)

    Article  Google Scholar 

  • Seeber, D.A., Cooper, R.L., Ciobanu, L., Pennington, C.H.: Rev. Sci. Instrum. 72, 2171–2179 (2001)

    Article  ADS  Google Scholar 

  • Webb, A.G.: Prog. Nucl. Magn. Reson. Spectrosc. 31, 1–42 (1997)

    Article  MathSciNet  Google Scholar 

  • Sillerud, L.O., McDowell, A.F., Adolphi, N.L., Serda, R.E., Adams, D.P., Vasile, M.J., Alam, T.M.: J. Magn. Reson. 181, 181–190 (2006)

    Article  ADS  Google Scholar 

  • McDowell, A.F., Adolphi, N.L.: J. Magn. Reson. 188, 74–82 (2007)

    Article  ADS  Google Scholar 

  • Halbach, K.: Nucl. Instrum. Methods 169, 1–10 (1980)

    Article  ADS  Google Scholar 

  • Perlo, J., Casanova, F., Blümich, B.: Science 315, 1110–1112 (2007)

    Article  ADS  Google Scholar 

  • Jachmann, R.C., Trease, D.R., Bouchard, L.S., Sakellariou, D., Martin, R.W., Schlueter, R.D., Budinger, T.F., Pines, A.: Rev. Sci. Instrum. 78, 035115 (2007)

    Article  ADS  Google Scholar 

  • www.asterenterprises.com

  • www.mrtechnology.co.jp/eng/index2.html

  • Perlo, J., Demas, V., Casanova, F., Meriles, C.A., Reimer, J.R., Pines, A., Blümich, B.: Science 308, 1279–1280 (2005)

    Article  Google Scholar 

  • Demas, V., Herberg, J., Malba, V., Bernhardt, A., Evans, L., Harvey, C., Chinn, S.C., Maxwell, R.S., Reimer, J.: J. Magn. Reson. 189, 121–129 (2007)

    Article  ADS  Google Scholar 

  • Manz, B., Benecke, M., Volke, F.: J. Magn. Reson. 192, 131–138 (2008)

    Article  ADS  Google Scholar 

  • Callaghan, P.T., Eccles, C.D., Seymour, J.D.: Rev. Sci. Instrum. 68, 4263–4270 (1997)

    Article  ADS  Google Scholar 

  • Appelt, S., Kühn, H., Häsing, F.W., Blümich, B.: Nat. Phys. 2, 105–109 (2006)

    Article  Google Scholar 

  • Marble, A.E., Mastikhin, I.V., Colpitts, B.G., Balcom, B.J.: J. Magn. Reson. 186, 100–104 (2007)

    Article  ADS  Google Scholar 

  • Zhang, X., Mahesh, V., Ng, D., Hubbard, R., Ailiana, A., O'Hare, B., Benesi, A., Webb, A., in: Hiller, J.-A. (ed.) Proceedings of the COMSOL Multiphysics Conference, Held at Boston, Mass., October 23–25, 2005. COMSOL, Burlington, Mass. (2005)

  • Hills, B.P., Wright, K.M., Gilles, D.G.: J. Magn. Reson. 175, 336–339 (2005)

    Article  ADS  Google Scholar 

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Authors and Affiliations

  1. ABQMR Inc., Albuquerque, New Mexico, USA

    A. McDowell & E. Fukushima

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  1. A. McDowell
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  2. E. Fukushima
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Authors' address: Andrew F. McDowell, ABQMR Inc., 2301 Yale Boulevard SE, suite C-2, Albuquerque, New Mexico 87106, USA

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McDowell, A., Fukushima, E. Ultracompact NMR: 1H Spectroscopy in a Subkilogram Magnet. Appl Magn Reson 35, 185–195 (2008). https://doi.org/10.1007/s00723-008-0151-3

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  • DOI: https://doi.org/10.1007/s00723-008-0151-3

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