Summary.
Evidence is rapidly accumulating that low-activity NAD(P)H oxidases homologous to that in phagocytic cells generate reactive oxygen species as signaling intermediates. In this review we discuss evidence that signaling NAD(P)H oxidases in part influence normal and malignant cell division by activating the redox-regulated transcription factor nuclear factor κB. The roles of growth-regulatory NAD(P)H oxidases in human airway smooth muscle and malignant melanoma are used as examples.
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Received May 4, 2002; accepted July 26, 2002; published online May 21, 2003
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ID="*" Correspondence and reprints: Department of Internal Medicine, Carolinas Medical Center, P.O. Box 32861, Charlotte, NC 28232, U.S.A.
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Brar, S., Kennedy, T., Quinn, M. et al. Redox signaling of NF-κB by membrane NAD(P)H oxidases in normal and malignant cells. Protoplasma 221, 117–127 (2003). https://doi.org/10.1007/s00709-002-0059-y
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DOI: https://doi.org/10.1007/s00709-002-0059-y