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Superfast synthesis, antibacterial and antifungal studies of halo-aryl and heterocyclic tagged 2,3-dihydro-1H-inden-1-one candidates

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Abstract

We describe a successful synthesis of halo-aryl and heterocyclic labelled 2,3-dihydro-1H-inden-1-one derivatives, as well as their antibacterial and antifungal properties. A total of 15 derivatives from 2,3-dihydro-1H-inden-1-one were synthesized by grinding, stirring, and ultrasound irradiation methods. The findings revealed that the ultrasound technique is increasingly satisfactory in terms of time and synthetic performance. The synthesized compounds have been tested for their antimicrobial activities against two Gram-positive (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli and Proteus vulgaris), and also two fungal agents (Aspergillus niger and Candida albicans). Most of the compounds were found to exert potent antibacterial action with broad-spectrum antibacterial activity. Likewise, few compounds were revealed to have potent antifungal properties against A. niger and C. albicans. The synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, and HRMS spectral techniques.

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Acknowledgements

Authors acknowledge central instrumentation facility, Savitribai Phule Pune University, Pune for 1H NMR, 13C NMR and HRMS spectral analyses, and central instrumentation center, KTHM College for FT-IR spectral analysis. Authors are thankful to Arts, Science and Commerce College, Manmad for providing necessary research facilities. The authors are grateful to Mr. Mahesh Patil for providing antimicrobial results. The authors gratefully acknowledge Dr. Aapoorva P. Hiray for his motivation for the research.

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Authors and Affiliations

  1. Department of Chemistry, Mahatma Gandhi Vidyamandir’s Arts, Science and Commerce College, Manmad, (Affiliated to Savitribai Phule Pune University, Pune), Nashik, 423 104, India

    Rahul A. Shinde, Vishnu A. Adole & Bapu S. Jagdale

  2. Department of Chemistry, Mahatma Gandhi Vidyamandir’s Loknete Vyankatrao Hiray Arts, Science and Commerce College Panchavati, (Affiliated to Savitribai Phule Pune University, Pune), Nashik, 422 003, India

    Thansing B. Pawar

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  1. Rahul A. Shinde
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  2. Vishnu A. Adole
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  3. Bapu S. Jagdale
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  4. Thansing B. Pawar
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Correspondence to Bapu S. Jagdale.

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Shinde, R.A., Adole, V.A., Jagdale, B.S. et al. Superfast synthesis, antibacterial and antifungal studies of halo-aryl and heterocyclic tagged 2,3-dihydro-1H-inden-1-one candidates. Monatsh Chem 152, 649–658 (2021). https://doi.org/10.1007/s00706-021-02772-0

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