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Three-component, solvent-free synthesis of Betti base catalyzed by sulfated polyborate

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Abstract

In this work, efficient, mild, and eco-friendly procedure of 1-aminoalkyl-2-phenol/Betti base from one-pot three-component condensations of aldehyde, phenol, and morpholine in the presence of sulfated polyborate catalyst, under a solvent-free condition at 100 °C, is described. The key advantages of the present method are short reaction time, high yields, aqueous work-up procedure, low cost, stable, reusable catalyst, and solvent-free reaction conditions.

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Acknowledgements

The authors are grateful to the Department of Science and Technology, New Delhi, India for their financial supports.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India

    Manisha S. Patil, Chetan K. Khatri & Ganesh U. Chaturbhuj

Authors
  1. Manisha S. Patil
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  2. Chetan K. Khatri
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  3. Ganesh U. Chaturbhuj
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Corresponding author

Correspondence to Ganesh U. Chaturbhuj.

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Patil, M.S., Khatri, C.K. & Chaturbhuj, G.U. Three-component, solvent-free synthesis of Betti base catalyzed by sulfated polyborate. Monatsh Chem 149, 1453–1457 (2018). https://doi.org/10.1007/s00706-018-2169-z

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  • DOI: https://doi.org/10.1007/s00706-018-2169-z

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