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Diastereoselective synthesis of peptidomimetics in one-pot Ugi reaction using trans-4-isopropylcyclohexanecarboxylic acid

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Abstract

The use of trans-4-isopropylcyclohexanecarboxylic acid as a substitution for the carboxylic acid component in the Ugi multicomponent condensation that leads to (1R,4R)-N-(2-(cyclohexylamino)-2-oxo-4-isopropylcyclohexane-1-carboxamide derivatives is described for the first time. One pot, clean reaction, and excellent yields are some advantages of this protocol.

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Acknowledgements

This research was supported by Grants from the Iran National Science Foundation (INSF).

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Authors and Affiliations

  1. Department of Chemistry, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran

    Sorour Ramezanpour & Akram Panahi

  2. Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany

    Frank Rominger

Authors
  1. Sorour Ramezanpour
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  2. Akram Panahi
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  3. Frank Rominger
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Correspondence to Sorour Ramezanpour.

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Ramezanpour, S., Panahi, A. & Rominger, F. Diastereoselective synthesis of peptidomimetics in one-pot Ugi reaction using trans-4-isopropylcyclohexanecarboxylic acid. Monatsh Chem 149, 625–633 (2018). https://doi.org/10.1007/s00706-017-2086-6

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  • DOI: https://doi.org/10.1007/s00706-017-2086-6

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