Abstract
Deproteinized natural rubber (DNR) latex was blended to each of gelatinized potato, rice, and glutinous starch (GPS, GRS, and GGS, respectively) dispersions to construct a thin film with glycerin added as plasticizer. The appropriate blended films were selected to load lidocaine and used as drug delivery. It was found that dispersions of each gelatinized starch type provided different viscosities due to their amylose/amylopectin ratios. GRS dispersion could be blended with DNR latex up to 20 part per hundred of rubber (phr) because of its lowest viscosity. All gelatinized starch dispersions could be mixed with DNR latex to provide good film at the concentration of 5 phr. The percentage of moisture uptake and swelling ratio of these films increased causing the blending of gelatinized starch in DNR. The higher amounts of gelatinized starch increased the swelling ratio and volumetric swelling of blended film. The ultimate tensile strengths of these blended films were not different comparing to DNR film itself, but they had a tendency to raise up when the amounts of gelatinized starch increased. At 5 phr of gelatinized starch, GPS provided the highest percentage of elongation at break of blended film while GGS and GRS gave the lower values, respectively. Lidocaine could be mixed in DNR and 5 phr GRS blended films by simple mixing during film preparation process. The compatibility of these blended films was confirmed by their morphology, fourier transform infrared spectroscopy and differential scanning calorimeter. Amorphous pattern of drug in these films was detected by X-ray diffraction. Lidocaine release profile from this film showed the slow release for up to 90% in 12 h.
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Ferreira M, Mendonca RJ, Coutinho-Netto J, Mulato M (2009) Braz J Phys 39:564
Linos A, Berekaa MM, Reichelt R, Keller U, Schmitt J, Flemming HC, Kroppenstedt RM, Steinbuchel A (2000) Appl Environ Microbiol 66:1639
Riyajan S, Sasithornsonti Y, Phinyocheep P (2012) Carbohydr Polym 89:251
Aielo PB, Borges FA, Romeira KM, Miranda MCR, Arruda LB, Filho PNL, Drago BC, Herculano RD (2014) Mat Res 17:146
Berges FA, Tercco A, Barros NR, Miranda MCR, Pierri EG, Santos AG, Herculano RD (2014) Eur J Med Plants 4:1420
Herculano RD, Silva CP, Ereno C, Guimaraes SAC, Kinoshita A, Graeff CF (2009) Mat Res 12:253
Panrat K, Boonme P, Taweepreda W, Pichayakorn W (2013) Adv Mat Res 747:91
Pichayakorn W, Suksaeree J, Boonme P, Taweepreda W, Ritthidej GC (2012) Ind Eng Chem Res 51:13393
Pichayakorn W, Suksaeree J, Boonme P, Amnuaikit T, Taweepreda W, Ritthidej GC (2012) J Membr Sci 411:81
Deval R, Ramesh V, Prasad G, Jain AK (2008) Indian J Dermatol Venereol Leprol 74:304
Sussman GL, Beezhold DH, Kurup VP (2002) J Allergy Clin Immunol 110:33
Yeang HY, Arif SAM, Yusof F, Sunderasan E (2002) Methods 27:32
Gray M, Bohacek L, Weir D, Zdanuk J (2007) J Wound Ostomy Cont Nurs 34:134
Afiq MM, Azura AR (2013) Int Biodeter Biodegr 85:139
Khalaf AI, Sadek EM (2011) J Appl Polym Sci 125:959
Ichazo MN, Albano C, Hernandez M, Gonzalez J, Pena J (2010) Rev Latin Am Metal Mat 31:71
Mele P, Coussy HA, Boisse SM, Dufresne A (2011) Biomacromol 12:1487
Rajisha KR, Maria HJ, Pothan LA, Ahmad Z, Thomas S (2014) Int J Biol Macromol 67:147
Waiprib R, Pichayakorn W, Boonme P, Taweepreda W, Suksaeree J (2015) Key Eng Mater 659:45
Pathan IB, Setty CM (2009) Trop J Pharm Res 8:173
Williams AC, Barry BW (2004) Adv Drug Deliv Rev 56:603
Pichayakorn W, Suksaeree J, Boonme P, Amnuaikit T, Taweepreda W, Ritthidej GC (2012) Ind Eng Chem Res 51:8442
Suksaeree J, Boonme P, Taweepreda W, Ritthidej GC, Pichayakorn W (2012) Chem Eng Res Des 90:906
Zhaoan C, Maicun D, Yong C, Gaohong H, Mimg W, Junde W (2004) J Membr Sci 235:73
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The authors would like to acknowledge the Prince of Songkla University for financial and laboratory support.
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Waiprib, R., Boonme, P., Taweepreda, W. et al. Deproteinized natural rubber latex/gelatinized starch blended films as drug delivery carrier. Monatsh Chem 148, 1223–1228 (2017). https://doi.org/10.1007/s00706-017-2005-x
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DOI: https://doi.org/10.1007/s00706-017-2005-x