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Phthalimide-N-oxyl salts: efficient organocatalysts for facile synthesis of (Z)-3-methyl-4-(arylmethylene)-isoxazole-5(4H)-one derivatives in water

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Abstract

Green and simple protocols have been developed for the synthesis of (Z)-3-methyl-4-(arylmethylene)isoxazole-5(4H)-one derivatives in the presence of tetrabutylammonium or potassium salts of phthalimide-N-oxyl, as transition metal-free catalysts, through the multicomponent reaction strategy in aqueous medium at ambient temperature. These procedures offer many advantages including clean reaction profiles, mild reaction conditions, short reaction times, high to quantitative yields, and straightforward work-up.

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Acknowledgments

We are thankful for the financial support from The Research Council of Iran University of Science and Technology (IUST), Tehran, Iran (Grant no. 160/354).

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Authors and Affiliations

  1. Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran

    Mohammad G. Dekamin & S. Zahra Peyman

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  1. Mohammad G. Dekamin
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  2. S. Zahra Peyman
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Correspondence to Mohammad G. Dekamin.

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Dekamin, M.G., Peyman, S.Z. Phthalimide-N-oxyl salts: efficient organocatalysts for facile synthesis of (Z)-3-methyl-4-(arylmethylene)-isoxazole-5(4H)-one derivatives in water. Monatsh Chem 147, 445–450 (2016). https://doi.org/10.1007/s00706-015-1565-x

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