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Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes

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Abstract

New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.

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Acknowledgments

This work was supported by the Ministry of Education, Science, and Technological Development of the Republic of Serbia (Grants OI 172055, III 41025, and III 46010).

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Authors and Affiliations

  1. Faculty of Agriculture, University of Belgrade, Belgrade, Serbia

    Nenad Filipović, Milena Savić & Miomir Nikšić

  2. Faculty of Chemistry, University of Belgrade, Belgrade, Serbia

    Natalija Polović, Brankica Rašković, Dragana Mitić, Katarina Anđelković & Tamara Todorović

  3. Faculty of Medicine, Institute of Medical and Clinical Biochemistry, University of Belgrade, Belgrade, Serbia

    Sonja Misirlić-Denčić & Marija Dulović

Authors
  1. Nenad Filipović
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  2. Natalija Polović
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  3. Brankica Rašković
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  4. Sonja Misirlić-Denčić
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  5. Marija Dulović
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  6. Milena Savić
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  9. Katarina Anđelković
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  10. Tamara Todorović
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Corresponding author

Correspondence to Tamara Todorović.

Electronic supplementary material

Below is the link to the electronic supplementary material. 1H–15N HMBC spectra of ligand HL1 and complex 1; representative antimicrobial activity plots for the ligands, complexes 1–6, and standard antimicotic and antibiotics, and the appropriate solid and liquid media used for cultivation of microorganisms are given in the Electronic Supplementary Material.

Supplementary material 1 (DOC 1503 kb)

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Filipović, N., Polović, N., Rašković, B. et al. Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes. Monatsh Chem 145, 1089–1099 (2014). https://doi.org/10.1007/s00706-014-1197-6

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  • DOI: https://doi.org/10.1007/s00706-014-1197-6

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